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Inter-individual stereotypy of the Platynereis larval visual connectome.

Randel N, Shahidi R, Verasztó C, Bezares-Calderón LA, Schmidt S, Jékely G - Elife (2015)

Bottom Line: It is less well understood, however, to what extent entire neural circuits of different individuals are similar.Previously, we reported the neuronal connectome of the visual eye circuit from the head of a Platynereis dumerilii larva (Randel et al., 2014).Our work shows the extent to which the eye circuitry in Platynereis larvae is hard-wired.

View Article: PubMed Central - PubMed

Affiliation: Max Planck Institute for Developmental Biology, Tübingen, Germany.

ABSTRACT
Developmental programs have the fidelity to form neural circuits with the same structure and function among individuals of the same species. It is less well understood, however, to what extent entire neural circuits of different individuals are similar. Previously, we reported the neuronal connectome of the visual eye circuit from the head of a Platynereis dumerilii larva (Randel et al., 2014). We now report a full-body serial section transmission electron microscopy (ssTEM) dataset of another larva of the same age, for which we describe the connectome of the visual eyes and the larval eyespots. Anatomical comparisons and quantitative analyses of the two circuits reveal a high inter-individual stereotypy of the cell complement, neuronal projections, and synaptic connectivity, including the left-right asymmetry in the connectivity of some neurons. Our work shows the extent to which the eye circuitry in Platynereis larvae is hard-wired.

No MeSH data available.


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Comparison of the neuronal projections and synapse positions of both individuals.Neuronal projections and synapse positions of (A) PRCar, (B) PRCal, (C) PRCpr, (D) PRCpl, (E) IN1ar, (F) IN1al, (G) IN1pr, (H) In1pl, (I) INtonr, (J) INtonl, (K) INsnr, (L) INsnl, (M) MNr1, (N) MNr2, (O) MNr3, (P) MNl1, (Q) MNl2, and (R) MNl3 cells in HT9-3 and HT9-4.DOI:http://dx.doi.org/10.7554/eLife.08069.008
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fig2s1: Comparison of the neuronal projections and synapse positions of both individuals.Neuronal projections and synapse positions of (A) PRCar, (B) PRCal, (C) PRCpr, (D) PRCpl, (E) IN1ar, (F) IN1al, (G) IN1pr, (H) In1pl, (I) INtonr, (J) INtonl, (K) INsnr, (L) INsnl, (M) MNr1, (N) MNr2, (O) MNr3, (P) MNl1, (Q) MNl2, and (R) MNl3 cells in HT9-3 and HT9-4.DOI:http://dx.doi.org/10.7554/eLife.08069.008

Mentions: To further test stereotypy at the single neuron level, we looked at the projection pattern and the distribution of pre- and post-synaptic sites in corresponding neurons between the two individuals. All neuron groups had similar projection patterns and spatial distribution of pre- and post-synaptic sites (Figure 2—figure supplement 1).


Inter-individual stereotypy of the Platynereis larval visual connectome.

Randel N, Shahidi R, Verasztó C, Bezares-Calderón LA, Schmidt S, Jékely G - Elife (2015)

Comparison of the neuronal projections and synapse positions of both individuals.Neuronal projections and synapse positions of (A) PRCar, (B) PRCal, (C) PRCpr, (D) PRCpl, (E) IN1ar, (F) IN1al, (G) IN1pr, (H) In1pl, (I) INtonr, (J) INtonl, (K) INsnr, (L) INsnl, (M) MNr1, (N) MNr2, (O) MNr3, (P) MNl1, (Q) MNl2, and (R) MNl3 cells in HT9-3 and HT9-4.DOI:http://dx.doi.org/10.7554/eLife.08069.008
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4477197&req=5

fig2s1: Comparison of the neuronal projections and synapse positions of both individuals.Neuronal projections and synapse positions of (A) PRCar, (B) PRCal, (C) PRCpr, (D) PRCpl, (E) IN1ar, (F) IN1al, (G) IN1pr, (H) In1pl, (I) INtonr, (J) INtonl, (K) INsnr, (L) INsnl, (M) MNr1, (N) MNr2, (O) MNr3, (P) MNl1, (Q) MNl2, and (R) MNl3 cells in HT9-3 and HT9-4.DOI:http://dx.doi.org/10.7554/eLife.08069.008
Mentions: To further test stereotypy at the single neuron level, we looked at the projection pattern and the distribution of pre- and post-synaptic sites in corresponding neurons between the two individuals. All neuron groups had similar projection patterns and spatial distribution of pre- and post-synaptic sites (Figure 2—figure supplement 1).

Bottom Line: It is less well understood, however, to what extent entire neural circuits of different individuals are similar.Previously, we reported the neuronal connectome of the visual eye circuit from the head of a Platynereis dumerilii larva (Randel et al., 2014).Our work shows the extent to which the eye circuitry in Platynereis larvae is hard-wired.

View Article: PubMed Central - PubMed

Affiliation: Max Planck Institute for Developmental Biology, Tübingen, Germany.

ABSTRACT
Developmental programs have the fidelity to form neural circuits with the same structure and function among individuals of the same species. It is less well understood, however, to what extent entire neural circuits of different individuals are similar. Previously, we reported the neuronal connectome of the visual eye circuit from the head of a Platynereis dumerilii larva (Randel et al., 2014). We now report a full-body serial section transmission electron microscopy (ssTEM) dataset of another larva of the same age, for which we describe the connectome of the visual eyes and the larval eyespots. Anatomical comparisons and quantitative analyses of the two circuits reveal a high inter-individual stereotypy of the cell complement, neuronal projections, and synaptic connectivity, including the left-right asymmetry in the connectivity of some neurons. Our work shows the extent to which the eye circuitry in Platynereis larvae is hard-wired.

No MeSH data available.


Related in: MedlinePlus