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An fMRI Study of Local Synchronization in Different Subfrequency Bands during the Continuous Feedback of Finger Force.

Zhang H, Gao ZZ, Zang YF - Biomed Res Int (2015)

Bottom Line: Conventional functional magnetic resonance imaging (fMRI) studies on motor feedback employ periodical blocked paradigm which does not allow frequency analysis of brain activity.Our results revealed that the five subfrequency bands of brain activity contributed to the changes of ReHo between real and sham feedback differently, and, more importantly, the changes in basal ganglia were only manifested in Slow-6, implicating the fact that ReHo in ultraslow band may be associated with the functional significance of BG, that is, motor control.These findings provide novel insights into the neural substrate underlying motor feedback, and properties of the ultraslow band of local synchronization deserve more attention in future explorations.

View Article: PubMed Central - PubMed

Affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China ; Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.

ABSTRACT
Conventional functional magnetic resonance imaging (fMRI) studies on motor feedback employ periodical blocked paradigm which does not allow frequency analysis of brain activity. Here, we carried out an fMRI study by using a continuous paradigm, that is, continuous (8 min) feedback of finger force. Borrowing an analytic method widely used in resting-state fMRI studies, that is, regional homogeneity (ReHo), we compared the local synchronization in some subfrequency bands between real and sham feedback, and the subbands were defined as Slow-6 (0.0-0.01 Hz), Slow-5 (0.01-0.027 Hz), Slow-4 (0.027-0.073 Hz), Slow-3 (0.073-0.198 Hz), and Slow-2 (0.198-0.25 Hz). Our results revealed that the five subfrequency bands of brain activity contributed to the changes of ReHo between real and sham feedback differently, and, more importantly, the changes in basal ganglia were only manifested in Slow-6, implicating the fact that ReHo in ultraslow band may be associated with the functional significance of BG, that is, motor control. These findings provide novel insights into the neural substrate underlying motor feedback, and properties of the ultraslow band of local synchronization deserve more attention in future explorations.

No MeSH data available.


Related in: MedlinePlus

Clusters showing significant main effect of the feedback condition and ReHo of each cluster in all subfrequency bands for real/sham feedback. (a) Slice views of the spatial maps for the main effect of the feedback condition. (b) ReHo of the visual cortex in all subfrequency bands for real/sham feedback; (c) ReHo of the mPFC in all subfrequency bands for real/sham feedback; (d) ReHo of the PCC in all subfrequency bands for real/sham feedback; (e) ReHo of the left BG in all subfrequency bands for real/sham feedback. Red represents real feedback and blue represents sham feedback.
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fig1: Clusters showing significant main effect of the feedback condition and ReHo of each cluster in all subfrequency bands for real/sham feedback. (a) Slice views of the spatial maps for the main effect of the feedback condition. (b) ReHo of the visual cortex in all subfrequency bands for real/sham feedback; (c) ReHo of the mPFC in all subfrequency bands for real/sham feedback; (d) ReHo of the PCC in all subfrequency bands for real/sham feedback; (e) ReHo of the left BG in all subfrequency bands for real/sham feedback. Red represents real feedback and blue represents sham feedback.

Mentions: According to the main effect of the feedback condition factor, differences of ReHo between real and sham feedback were distributed in four clusters, including bilateral visual cortex (containing bilateral inferior occipital gyrus, bilateral middle occipital gyrus, and bilateral calcarine), bilateral posterior cingulate cortex (PCC), bilateral medial prefrontal cortex (mPFC), and left BG (mainly located in putamen) (Table 1 and Figure 1(a)). For these clusters, the mean ReHo across all investigated subfrequency bands and subjects were shown in Figures 1(b)–1(e). Visual cortex showed lower ReHo while comparing real feedback with sham feedback (Figure 1(b)). As Figure 1(c) shows, ReHo for the mPFC was greater in real feedback than it was in sham feedback. As to the PCC, real feedback recruited greater ReHo than sham feedback (Figure 1(d)), and, for the left BG, greater ReHo was observed in real feedback as compared with that in sham feedback (Figure 1(e)). The main effect of the frequency band factor was similar to the findings of the previous study [23], and it was not presented here because it is not the focus of the current study.


An fMRI Study of Local Synchronization in Different Subfrequency Bands during the Continuous Feedback of Finger Force.

Zhang H, Gao ZZ, Zang YF - Biomed Res Int (2015)

Clusters showing significant main effect of the feedback condition and ReHo of each cluster in all subfrequency bands for real/sham feedback. (a) Slice views of the spatial maps for the main effect of the feedback condition. (b) ReHo of the visual cortex in all subfrequency bands for real/sham feedback; (c) ReHo of the mPFC in all subfrequency bands for real/sham feedback; (d) ReHo of the PCC in all subfrequency bands for real/sham feedback; (e) ReHo of the left BG in all subfrequency bands for real/sham feedback. Red represents real feedback and blue represents sham feedback.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477192&req=5

fig1: Clusters showing significant main effect of the feedback condition and ReHo of each cluster in all subfrequency bands for real/sham feedback. (a) Slice views of the spatial maps for the main effect of the feedback condition. (b) ReHo of the visual cortex in all subfrequency bands for real/sham feedback; (c) ReHo of the mPFC in all subfrequency bands for real/sham feedback; (d) ReHo of the PCC in all subfrequency bands for real/sham feedback; (e) ReHo of the left BG in all subfrequency bands for real/sham feedback. Red represents real feedback and blue represents sham feedback.
Mentions: According to the main effect of the feedback condition factor, differences of ReHo between real and sham feedback were distributed in four clusters, including bilateral visual cortex (containing bilateral inferior occipital gyrus, bilateral middle occipital gyrus, and bilateral calcarine), bilateral posterior cingulate cortex (PCC), bilateral medial prefrontal cortex (mPFC), and left BG (mainly located in putamen) (Table 1 and Figure 1(a)). For these clusters, the mean ReHo across all investigated subfrequency bands and subjects were shown in Figures 1(b)–1(e). Visual cortex showed lower ReHo while comparing real feedback with sham feedback (Figure 1(b)). As Figure 1(c) shows, ReHo for the mPFC was greater in real feedback than it was in sham feedback. As to the PCC, real feedback recruited greater ReHo than sham feedback (Figure 1(d)), and, for the left BG, greater ReHo was observed in real feedback as compared with that in sham feedback (Figure 1(e)). The main effect of the frequency band factor was similar to the findings of the previous study [23], and it was not presented here because it is not the focus of the current study.

Bottom Line: Conventional functional magnetic resonance imaging (fMRI) studies on motor feedback employ periodical blocked paradigm which does not allow frequency analysis of brain activity.Our results revealed that the five subfrequency bands of brain activity contributed to the changes of ReHo between real and sham feedback differently, and, more importantly, the changes in basal ganglia were only manifested in Slow-6, implicating the fact that ReHo in ultraslow band may be associated with the functional significance of BG, that is, motor control.These findings provide novel insights into the neural substrate underlying motor feedback, and properties of the ultraslow band of local synchronization deserve more attention in future explorations.

View Article: PubMed Central - PubMed

Affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China ; Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.

ABSTRACT
Conventional functional magnetic resonance imaging (fMRI) studies on motor feedback employ periodical blocked paradigm which does not allow frequency analysis of brain activity. Here, we carried out an fMRI study by using a continuous paradigm, that is, continuous (8 min) feedback of finger force. Borrowing an analytic method widely used in resting-state fMRI studies, that is, regional homogeneity (ReHo), we compared the local synchronization in some subfrequency bands between real and sham feedback, and the subbands were defined as Slow-6 (0.0-0.01 Hz), Slow-5 (0.01-0.027 Hz), Slow-4 (0.027-0.073 Hz), Slow-3 (0.073-0.198 Hz), and Slow-2 (0.198-0.25 Hz). Our results revealed that the five subfrequency bands of brain activity contributed to the changes of ReHo between real and sham feedback differently, and, more importantly, the changes in basal ganglia were only manifested in Slow-6, implicating the fact that ReHo in ultraslow band may be associated with the functional significance of BG, that is, motor control. These findings provide novel insights into the neural substrate underlying motor feedback, and properties of the ultraslow band of local synchronization deserve more attention in future explorations.

No MeSH data available.


Related in: MedlinePlus