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Cerebral Activity Changes in Different Traditional Chinese Medicine Patterns of Psychogenic Erectile Dysfunction Patients.

Liu Q, Zhang P, Pan J, Li Z, Liu J, Li G, Qin W, You Y, Yu X, Sun J, Dong M, Gong Q, Guo J, Chang D - Evid Based Complement Alternat Med (2015)

Bottom Line: Results.Compared to the patients with liver-qi stagnation and spleen deficiency pattern (LSSDP), the patients with kidney-yang deficiency pattern (KDP) showed an increased activity in bilateral brainstem, cerebellum, hippocampus, and the right insula, thalamus, MCC, and a decreased activity in bilateral putamen, medial frontal gyrus, temporal pole, and the right caudate nucleus, OFC, anterior cingulate cortex, and posterior cingulate cortex (P < 0.005).Conclusions.

View Article: PubMed Central - PubMed

Affiliation: The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China.

ABSTRACT
Background. Pattern differentiation is the foundation of traditional Chinese medicine (TCM) treatment for erectile dysfunction (ED). This study aims to investigate the differences in cerebral activity in ED patients with different TCM patterns. Methods. 27 psychogenic ED patients and 27 healthy subjects (HS) were enrolled in this study. Each participant underwent an fMRI scan in resting state. The fractional amplitude of low-frequency fluctuation (fALFF) was used to detect the brain activity changes in ED patients with different patterns. Results. Compared to HS, ED patients showed an increased cerebral activity in bilateral cerebellum, insula, globus pallidus, parahippocampal gyrus, orbitofrontal cortex (OFC), and middle cingulate cortex (MCC). Compared to the patients with liver-qi stagnation and spleen deficiency pattern (LSSDP), the patients with kidney-yang deficiency pattern (KDP) showed an increased activity in bilateral brainstem, cerebellum, hippocampus, and the right insula, thalamus, MCC, and a decreased activity in bilateral putamen, medial frontal gyrus, temporal pole, and the right caudate nucleus, OFC, anterior cingulate cortex, and posterior cingulate cortex (P < 0.005). Conclusions. The ED patients with different TCM patterns showed different brain activities. The differences in cerebral activity between LSSDP and KDP were mainly in the emotion-related regions, including prefrontal cortex and cingulated cortex.

No MeSH data available.


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The differences in cerebral activities between psychogenic ED patients with different TCM patterns. (a) The differences in cerebral activities between psychogenic ED patients and HS. Compared to HS, psychogenic ED patients showed abnormal cerebral activity in brainstem, cerebellum, basal ganglia, and multiple limbic regions including insula, MCC, PFC, parahippocampal gyrus, and parietal, temporal lobes. (P < 0.005, a minimal cluster size of 50 voxels). (b) The differences in cerebral activities between ED patients with different TCM patterns. The brain regions associated with emotion modulation such as cerebellum, OFC, ACC, and MCC are the main different brain areas between psychogenic ED patients with kidney-yang deficiency pattern and liver-qi stagnation and spleen deficiency pattern (P < 0.005, a minimal cluster size of 50 voxels).
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fig1: The differences in cerebral activities between psychogenic ED patients with different TCM patterns. (a) The differences in cerebral activities between psychogenic ED patients and HS. Compared to HS, psychogenic ED patients showed abnormal cerebral activity in brainstem, cerebellum, basal ganglia, and multiple limbic regions including insula, MCC, PFC, parahippocampal gyrus, and parietal, temporal lobes. (P < 0.005, a minimal cluster size of 50 voxels). (b) The differences in cerebral activities between ED patients with different TCM patterns. The brain regions associated with emotion modulation such as cerebellum, OFC, ACC, and MCC are the main different brain areas between psychogenic ED patients with kidney-yang deficiency pattern and liver-qi stagnation and spleen deficiency pattern (P < 0.005, a minimal cluster size of 50 voxels).

Mentions: Compared to HS, the ED patients showed an increased cerebral activity in bilateral cerebellum, insula (BA47∖48), globus pallidus, parahippocampal gyrus (BA20), OFC (BA11) and middle cingulate cortex (MCC) (BA23), and the right putamen, superior temporal gyrus (BA21), and the left supplementary motor area (BA32, BA6) and rectus gyrus (BA11) and a decreased cerebral activity in bilateral brainstem and precuneus (BA7) and the right MCC (BA23), superior parietal lobule (BA5) and superior temporal gyrus (BA48), and the left precentral gyrus (BA6) (P < 0.005, a minimal cluster size of 50 voxels) (Table 2, Figure 1(a)).


Cerebral Activity Changes in Different Traditional Chinese Medicine Patterns of Psychogenic Erectile Dysfunction Patients.

Liu Q, Zhang P, Pan J, Li Z, Liu J, Li G, Qin W, You Y, Yu X, Sun J, Dong M, Gong Q, Guo J, Chang D - Evid Based Complement Alternat Med (2015)

The differences in cerebral activities between psychogenic ED patients with different TCM patterns. (a) The differences in cerebral activities between psychogenic ED patients and HS. Compared to HS, psychogenic ED patients showed abnormal cerebral activity in brainstem, cerebellum, basal ganglia, and multiple limbic regions including insula, MCC, PFC, parahippocampal gyrus, and parietal, temporal lobes. (P < 0.005, a minimal cluster size of 50 voxels). (b) The differences in cerebral activities between ED patients with different TCM patterns. The brain regions associated with emotion modulation such as cerebellum, OFC, ACC, and MCC are the main different brain areas between psychogenic ED patients with kidney-yang deficiency pattern and liver-qi stagnation and spleen deficiency pattern (P < 0.005, a minimal cluster size of 50 voxels).
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4477190&req=5

fig1: The differences in cerebral activities between psychogenic ED patients with different TCM patterns. (a) The differences in cerebral activities between psychogenic ED patients and HS. Compared to HS, psychogenic ED patients showed abnormal cerebral activity in brainstem, cerebellum, basal ganglia, and multiple limbic regions including insula, MCC, PFC, parahippocampal gyrus, and parietal, temporal lobes. (P < 0.005, a minimal cluster size of 50 voxels). (b) The differences in cerebral activities between ED patients with different TCM patterns. The brain regions associated with emotion modulation such as cerebellum, OFC, ACC, and MCC are the main different brain areas between psychogenic ED patients with kidney-yang deficiency pattern and liver-qi stagnation and spleen deficiency pattern (P < 0.005, a minimal cluster size of 50 voxels).
Mentions: Compared to HS, the ED patients showed an increased cerebral activity in bilateral cerebellum, insula (BA47∖48), globus pallidus, parahippocampal gyrus (BA20), OFC (BA11) and middle cingulate cortex (MCC) (BA23), and the right putamen, superior temporal gyrus (BA21), and the left supplementary motor area (BA32, BA6) and rectus gyrus (BA11) and a decreased cerebral activity in bilateral brainstem and precuneus (BA7) and the right MCC (BA23), superior parietal lobule (BA5) and superior temporal gyrus (BA48), and the left precentral gyrus (BA6) (P < 0.005, a minimal cluster size of 50 voxels) (Table 2, Figure 1(a)).

Bottom Line: Results.Compared to the patients with liver-qi stagnation and spleen deficiency pattern (LSSDP), the patients with kidney-yang deficiency pattern (KDP) showed an increased activity in bilateral brainstem, cerebellum, hippocampus, and the right insula, thalamus, MCC, and a decreased activity in bilateral putamen, medial frontal gyrus, temporal pole, and the right caudate nucleus, OFC, anterior cingulate cortex, and posterior cingulate cortex (P < 0.005).Conclusions.

View Article: PubMed Central - PubMed

Affiliation: The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China.

ABSTRACT
Background. Pattern differentiation is the foundation of traditional Chinese medicine (TCM) treatment for erectile dysfunction (ED). This study aims to investigate the differences in cerebral activity in ED patients with different TCM patterns. Methods. 27 psychogenic ED patients and 27 healthy subjects (HS) were enrolled in this study. Each participant underwent an fMRI scan in resting state. The fractional amplitude of low-frequency fluctuation (fALFF) was used to detect the brain activity changes in ED patients with different patterns. Results. Compared to HS, ED patients showed an increased cerebral activity in bilateral cerebellum, insula, globus pallidus, parahippocampal gyrus, orbitofrontal cortex (OFC), and middle cingulate cortex (MCC). Compared to the patients with liver-qi stagnation and spleen deficiency pattern (LSSDP), the patients with kidney-yang deficiency pattern (KDP) showed an increased activity in bilateral brainstem, cerebellum, hippocampus, and the right insula, thalamus, MCC, and a decreased activity in bilateral putamen, medial frontal gyrus, temporal pole, and the right caudate nucleus, OFC, anterior cingulate cortex, and posterior cingulate cortex (P < 0.005). Conclusions. The ED patients with different TCM patterns showed different brain activities. The differences in cerebral activity between LSSDP and KDP were mainly in the emotion-related regions, including prefrontal cortex and cingulated cortex.

No MeSH data available.


Related in: MedlinePlus