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Correlations between Phlegm Syndrome of Chinese Medicine and Coronary Angiography: A Systematic Review and Meta-Analysis.

Zhang QY, Liang H, Gong HW, Huang HY, Zhou XQ, Sun X - Evid Based Complement Alternat Med (2015)

Bottom Line: According to inclusion criteria, a total of 30 studies involving 5,055 CAD patients were included.We concluded that the coronary arteries lesions of CAD patients with phlegm syndrome were more severe than those with nonphlegm syndromes.Phlegm syndrome should, therefore, be regarded as a dangerous pattern of CAD with worse prognosis.

View Article: PubMed Central - PubMed

Affiliation: Hunan University of Chinese Medicine, Science-Education Industrial Park, Yuelu Region, Changsha 410208, China.

ABSTRACT
Phlegm is one of the most common patterns of coronary artery disease (CAD) in Chinese medicine. Our research was aimed at investigating the association between phlegm syndrome of CAD and coronary angiography (CAG) by meta-analysis. According to inclusion criteria, a total of 30 studies involving 5,055 CAD patients were included. The meta-analysis showed that phlegm syndrome patients were prone to multivessel disease (28 studies, OR = 1.53, 95% CI, 1.24 to 1.88, P < 0.01) and higher Gensini score (2 studies, OR = 5.90, 95% CI, 1.86 to 9.94, P = 0.004), but not obviously relevant to severe stenosis (≥75%) of coronary arteries (13 studies, OR = 1.20, 95% CI, 0.63 to 2.27, P = 0.57). We concluded that the coronary arteries lesions of CAD patients with phlegm syndrome were more severe than those with nonphlegm syndromes. Phlegm syndrome should, therefore, be regarded as a dangerous pattern of CAD with worse prognosis.

No MeSH data available.


Related in: MedlinePlus

Graphic display of quality assessment. Note: (1) consecutive or randomized patients; (2) avoiding inappropriate exclusions; (3) inclusion criteria of patients described; (4) syndrome differentiation results interpreted without knowledge of the results of CAG; (5) syndrome differentiation by more than two independent doctors; (6) CAG results interpreted without knowledge of the results of the syndrome differentiation; (7) an appropriate interval between syndrome differentiation and CAG; (8) perspective design.
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fig2: Graphic display of quality assessment. Note: (1) consecutive or randomized patients; (2) avoiding inappropriate exclusions; (3) inclusion criteria of patients described; (4) syndrome differentiation results interpreted without knowledge of the results of CAG; (5) syndrome differentiation by more than two independent doctors; (6) CAG results interpreted without knowledge of the results of the syndrome differentiation; (7) an appropriate interval between syndrome differentiation and CAG; (8) perspective design.

Mentions: Table 3 and Figure 2 summarized the quality assessment for the 30 full-text studies. Quality assessment of most studies was not satisfactory, especially the blinding method. None of the studies for those interpreting syndrome differentiation data were blinded to the results of the reference standard test (test review bias avoided) and vice versa (diagnostic review bias avoided).


Correlations between Phlegm Syndrome of Chinese Medicine and Coronary Angiography: A Systematic Review and Meta-Analysis.

Zhang QY, Liang H, Gong HW, Huang HY, Zhou XQ, Sun X - Evid Based Complement Alternat Med (2015)

Graphic display of quality assessment. Note: (1) consecutive or randomized patients; (2) avoiding inappropriate exclusions; (3) inclusion criteria of patients described; (4) syndrome differentiation results interpreted without knowledge of the results of CAG; (5) syndrome differentiation by more than two independent doctors; (6) CAG results interpreted without knowledge of the results of the syndrome differentiation; (7) an appropriate interval between syndrome differentiation and CAG; (8) perspective design.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477186&req=5

fig2: Graphic display of quality assessment. Note: (1) consecutive or randomized patients; (2) avoiding inappropriate exclusions; (3) inclusion criteria of patients described; (4) syndrome differentiation results interpreted without knowledge of the results of CAG; (5) syndrome differentiation by more than two independent doctors; (6) CAG results interpreted without knowledge of the results of the syndrome differentiation; (7) an appropriate interval between syndrome differentiation and CAG; (8) perspective design.
Mentions: Table 3 and Figure 2 summarized the quality assessment for the 30 full-text studies. Quality assessment of most studies was not satisfactory, especially the blinding method. None of the studies for those interpreting syndrome differentiation data were blinded to the results of the reference standard test (test review bias avoided) and vice versa (diagnostic review bias avoided).

Bottom Line: According to inclusion criteria, a total of 30 studies involving 5,055 CAD patients were included.We concluded that the coronary arteries lesions of CAD patients with phlegm syndrome were more severe than those with nonphlegm syndromes.Phlegm syndrome should, therefore, be regarded as a dangerous pattern of CAD with worse prognosis.

View Article: PubMed Central - PubMed

Affiliation: Hunan University of Chinese Medicine, Science-Education Industrial Park, Yuelu Region, Changsha 410208, China.

ABSTRACT
Phlegm is one of the most common patterns of coronary artery disease (CAD) in Chinese medicine. Our research was aimed at investigating the association between phlegm syndrome of CAD and coronary angiography (CAG) by meta-analysis. According to inclusion criteria, a total of 30 studies involving 5,055 CAD patients were included. The meta-analysis showed that phlegm syndrome patients were prone to multivessel disease (28 studies, OR = 1.53, 95% CI, 1.24 to 1.88, P < 0.01) and higher Gensini score (2 studies, OR = 5.90, 95% CI, 1.86 to 9.94, P = 0.004), but not obviously relevant to severe stenosis (≥75%) of coronary arteries (13 studies, OR = 1.20, 95% CI, 0.63 to 2.27, P = 0.57). We concluded that the coronary arteries lesions of CAD patients with phlegm syndrome were more severe than those with nonphlegm syndromes. Phlegm syndrome should, therefore, be regarded as a dangerous pattern of CAD with worse prognosis.

No MeSH data available.


Related in: MedlinePlus