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Correlations between Phlegm Syndrome of Chinese Medicine and Coronary Angiography: A Systematic Review and Meta-Analysis.

Zhang QY, Liang H, Gong HW, Huang HY, Zhou XQ, Sun X - Evid Based Complement Alternat Med (2015)

Bottom Line: According to inclusion criteria, a total of 30 studies involving 5,055 CAD patients were included.We concluded that the coronary arteries lesions of CAD patients with phlegm syndrome were more severe than those with nonphlegm syndromes.Phlegm syndrome should, therefore, be regarded as a dangerous pattern of CAD with worse prognosis.

View Article: PubMed Central - PubMed

Affiliation: Hunan University of Chinese Medicine, Science-Education Industrial Park, Yuelu Region, Changsha 410208, China.

ABSTRACT
Phlegm is one of the most common patterns of coronary artery disease (CAD) in Chinese medicine. Our research was aimed at investigating the association between phlegm syndrome of CAD and coronary angiography (CAG) by meta-analysis. According to inclusion criteria, a total of 30 studies involving 5,055 CAD patients were included. The meta-analysis showed that phlegm syndrome patients were prone to multivessel disease (28 studies, OR = 1.53, 95% CI, 1.24 to 1.88, P < 0.01) and higher Gensini score (2 studies, OR = 5.90, 95% CI, 1.86 to 9.94, P = 0.004), but not obviously relevant to severe stenosis (≥75%) of coronary arteries (13 studies, OR = 1.20, 95% CI, 0.63 to 2.27, P = 0.57). We concluded that the coronary arteries lesions of CAD patients with phlegm syndrome were more severe than those with nonphlegm syndromes. Phlegm syndrome should, therefore, be regarded as a dangerous pattern of CAD with worse prognosis.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of studies considered for the review.
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Related In: Results  -  Collection


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fig1: Flow diagram of studies considered for the review.

Mentions: The literature process was outlined in Figure 1, and 88 potentially relevant studies were retrieved for detailed evaluation. 58 were excluded because (1) they had overlapping data; (2) it was not possible to calculate absolute numbers from the presented data; (3) or data was inconsistent in the context of the article. Finally, 30 included studies met the inclusion criteria, 29 Chinese articles, and 1 English article. All of the studies were from hospitals of China. Study and population characteristics of the included studies are summarized in Table 2, involving a total of 5,029 patients, reporting age ranging from 37 to 87 years. Analysis of the syndromes showed that there were 1,674 (33.3%) phlegm syndrome patients compared with 3,355 (66.7%) of the others. Most studies reported elective assessment for CAD, with study groups including those with suspected and known CAD. Eight studies were theses from medical universities of China. Methods for syndrome differentiation of CAD were divided into syndrome-element differentiation (SED) and other methods called conventional syndrome differentiation (CSD). CSD contains the classical syndrome differentiation methods, such as viscera syndrome differentiation and eight-principal syndrome differentiation [2].


Correlations between Phlegm Syndrome of Chinese Medicine and Coronary Angiography: A Systematic Review and Meta-Analysis.

Zhang QY, Liang H, Gong HW, Huang HY, Zhou XQ, Sun X - Evid Based Complement Alternat Med (2015)

Flow diagram of studies considered for the review.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477186&req=5

fig1: Flow diagram of studies considered for the review.
Mentions: The literature process was outlined in Figure 1, and 88 potentially relevant studies were retrieved for detailed evaluation. 58 were excluded because (1) they had overlapping data; (2) it was not possible to calculate absolute numbers from the presented data; (3) or data was inconsistent in the context of the article. Finally, 30 included studies met the inclusion criteria, 29 Chinese articles, and 1 English article. All of the studies were from hospitals of China. Study and population characteristics of the included studies are summarized in Table 2, involving a total of 5,029 patients, reporting age ranging from 37 to 87 years. Analysis of the syndromes showed that there were 1,674 (33.3%) phlegm syndrome patients compared with 3,355 (66.7%) of the others. Most studies reported elective assessment for CAD, with study groups including those with suspected and known CAD. Eight studies were theses from medical universities of China. Methods for syndrome differentiation of CAD were divided into syndrome-element differentiation (SED) and other methods called conventional syndrome differentiation (CSD). CSD contains the classical syndrome differentiation methods, such as viscera syndrome differentiation and eight-principal syndrome differentiation [2].

Bottom Line: According to inclusion criteria, a total of 30 studies involving 5,055 CAD patients were included.We concluded that the coronary arteries lesions of CAD patients with phlegm syndrome were more severe than those with nonphlegm syndromes.Phlegm syndrome should, therefore, be regarded as a dangerous pattern of CAD with worse prognosis.

View Article: PubMed Central - PubMed

Affiliation: Hunan University of Chinese Medicine, Science-Education Industrial Park, Yuelu Region, Changsha 410208, China.

ABSTRACT
Phlegm is one of the most common patterns of coronary artery disease (CAD) in Chinese medicine. Our research was aimed at investigating the association between phlegm syndrome of CAD and coronary angiography (CAG) by meta-analysis. According to inclusion criteria, a total of 30 studies involving 5,055 CAD patients were included. The meta-analysis showed that phlegm syndrome patients were prone to multivessel disease (28 studies, OR = 1.53, 95% CI, 1.24 to 1.88, P < 0.01) and higher Gensini score (2 studies, OR = 5.90, 95% CI, 1.86 to 9.94, P = 0.004), but not obviously relevant to severe stenosis (≥75%) of coronary arteries (13 studies, OR = 1.20, 95% CI, 0.63 to 2.27, P = 0.57). We concluded that the coronary arteries lesions of CAD patients with phlegm syndrome were more severe than those with nonphlegm syndromes. Phlegm syndrome should, therefore, be regarded as a dangerous pattern of CAD with worse prognosis.

No MeSH data available.


Related in: MedlinePlus