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Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer's Disease Using Various Methods of Resting-State FMRI Analysis.

Cha J, Hwang JM, Jo HJ, Seo SW, Na DL, Lee JM - Biomed Res Int (2015)

Bottom Line: The purpose of our study was to investigate the functional differences in aMCI and AD patients compared with healthy subjects in a meta-analysis.Nevertheless, patients with aMCI and AD displayed consistently decreased functional characteristics with all approaches.All approaches showed that the functional characteristics in the left parahippocampal gyrus were decreased in AD patients compared with healthy subjects.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, Hanyang University, Seoul 133-791, Republic of Korea.

ABSTRACT
Resting-state functional magnetic resonance imaging (RS FMRI) has been widely used to analyze functional alterations in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) patients. Although many clinical studies of aMCI and AD patients using RS FMRI have been undertaken, conducting a meta-analysis has not been easy because of seed selection bias by the investigators. The purpose of our study was to investigate the functional differences in aMCI and AD patients compared with healthy subjects in a meta-analysis. Thus, a multimethod approach using regional homogeneity, amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and global brain connectivity was used to investigate differences between three groups based on previously published data. According to the choice of RS FMRI approach used, the patterns of functional alteration were slightly different. Nevertheless, patients with aMCI and AD displayed consistently decreased functional characteristics with all approaches. All approaches showed that the functional characteristics in the left parahippocampal gyrus were decreased in AD patients compared with healthy subjects. Although some regions were slightly different according to the different RS FMRI approaches, patients with aMCI and AD showed a consistent pattern of decreased functional characteristics with all approaches.

No MeSH data available.


Related in: MedlinePlus

The mean images of each resting-state FMRI analysis approach: (a) regional homogeneity (ReHo), (b) amplitude of low-frequency fluctuation (ALFF), (c) fractional ALFF, and (d) global brain connectivity (GBC). The first row of each approach is the map for the healthy subjects, the second row of each approach is the map for the patients with aMCI, and the third row of each approach is the map for the patients with AD. The images are oriented with the anterior side placed at the top and the left side placed to the right. The red and blue colors represent positive and negative functional connectivity, respectively.
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fig1: The mean images of each resting-state FMRI analysis approach: (a) regional homogeneity (ReHo), (b) amplitude of low-frequency fluctuation (ALFF), (c) fractional ALFF, and (d) global brain connectivity (GBC). The first row of each approach is the map for the healthy subjects, the second row of each approach is the map for the patients with aMCI, and the third row of each approach is the map for the patients with AD. The images are oriented with the anterior side placed at the top and the left side placed to the right. The red and blue colors represent positive and negative functional connectivity, respectively.

Mentions: To allow visual inspection of the different approaches, mean images were generated for each group. The majority of the clusters were consistent across all groups and the patterns were quite similar to the previous results for each approach (Figure 1). These regions included the PCC/precuneus, middle frontal gyrus, anterior cingulate cortex (ACC), inferior parietal lobule, and middle temporal gyrus.


Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer's Disease Using Various Methods of Resting-State FMRI Analysis.

Cha J, Hwang JM, Jo HJ, Seo SW, Na DL, Lee JM - Biomed Res Int (2015)

The mean images of each resting-state FMRI analysis approach: (a) regional homogeneity (ReHo), (b) amplitude of low-frequency fluctuation (ALFF), (c) fractional ALFF, and (d) global brain connectivity (GBC). The first row of each approach is the map for the healthy subjects, the second row of each approach is the map for the patients with aMCI, and the third row of each approach is the map for the patients with AD. The images are oriented with the anterior side placed at the top and the left side placed to the right. The red and blue colors represent positive and negative functional connectivity, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477185&req=5

fig1: The mean images of each resting-state FMRI analysis approach: (a) regional homogeneity (ReHo), (b) amplitude of low-frequency fluctuation (ALFF), (c) fractional ALFF, and (d) global brain connectivity (GBC). The first row of each approach is the map for the healthy subjects, the second row of each approach is the map for the patients with aMCI, and the third row of each approach is the map for the patients with AD. The images are oriented with the anterior side placed at the top and the left side placed to the right. The red and blue colors represent positive and negative functional connectivity, respectively.
Mentions: To allow visual inspection of the different approaches, mean images were generated for each group. The majority of the clusters were consistent across all groups and the patterns were quite similar to the previous results for each approach (Figure 1). These regions included the PCC/precuneus, middle frontal gyrus, anterior cingulate cortex (ACC), inferior parietal lobule, and middle temporal gyrus.

Bottom Line: The purpose of our study was to investigate the functional differences in aMCI and AD patients compared with healthy subjects in a meta-analysis.Nevertheless, patients with aMCI and AD displayed consistently decreased functional characteristics with all approaches.All approaches showed that the functional characteristics in the left parahippocampal gyrus were decreased in AD patients compared with healthy subjects.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, Hanyang University, Seoul 133-791, Republic of Korea.

ABSTRACT
Resting-state functional magnetic resonance imaging (RS FMRI) has been widely used to analyze functional alterations in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) patients. Although many clinical studies of aMCI and AD patients using RS FMRI have been undertaken, conducting a meta-analysis has not been easy because of seed selection bias by the investigators. The purpose of our study was to investigate the functional differences in aMCI and AD patients compared with healthy subjects in a meta-analysis. Thus, a multimethod approach using regional homogeneity, amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and global brain connectivity was used to investigate differences between three groups based on previously published data. According to the choice of RS FMRI approach used, the patterns of functional alteration were slightly different. Nevertheless, patients with aMCI and AD displayed consistently decreased functional characteristics with all approaches. All approaches showed that the functional characteristics in the left parahippocampal gyrus were decreased in AD patients compared with healthy subjects. Although some regions were slightly different according to the different RS FMRI approaches, patients with aMCI and AD showed a consistent pattern of decreased functional characteristics with all approaches.

No MeSH data available.


Related in: MedlinePlus