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Metagenomics: A new horizon in cancer research.

Banerjee J, Mishra N, Dhas Y - Meta Gene (2015)

Bottom Line: About 16.1% of cancers are associated with microbial infection.Metagenomics is an equitable way of identifying and studying micro-organisms within their habitat.Different types of micro-organisms have been found to be linked to various types of cancers, thus, contributing significantly in understanding the disease at molecular level.

View Article: PubMed Central - PubMed

Affiliation: Symbiosis School of Biomedical Sciences, Symbiosis International University, Pune 412115, India.

ABSTRACT
Metagenomics has broadened the scope of targeting microbes responsible for inducing various types of cancers. About 16.1% of cancers are associated with microbial infection. Metagenomics is an equitable way of identifying and studying micro-organisms within their habitat. In cancer research, this approach has revolutionized the way of identifying, analyzing and targeting the microbial diversity present in the tissue specimens of cancer patients. The genomic analyses of these micro-organisms through next generation sequencing techniques invariably facilitate in recognizing the microbial population in biopsies and their evolutionary relationships with each other. In this review an attempt has been made to generate current metagenomic view on cancer microbiota. Different types of micro-organisms have been found to be linked to various types of cancers, thus, contributing significantly in understanding the disease at molecular level.

No MeSH data available.


Related in: MedlinePlus

Mechanism of oncogenesis induced due to change in the microbiota (Chang and Parsonnet, 2010). In this figure, environmental imbalances result in alteration of normal microbiota, subsequent formation of toxic metabolites, chronic inflammation, oncoproteins. The generation of free radicals followed by DNA damage and loss of function of p53 tumor suppressor gene, result in uncontrolled proliferation of cells and formation of cancer. DCA — Deoxycholic acid; BCL10 — B cell lymphoma/leukemia 10 protein; NF-kB — Nuclear Factor kappa B; ROS/RNS — Reactive oxygen species/Reactive nitrogen species.
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f0005: Mechanism of oncogenesis induced due to change in the microbiota (Chang and Parsonnet, 2010). In this figure, environmental imbalances result in alteration of normal microbiota, subsequent formation of toxic metabolites, chronic inflammation, oncoproteins. The generation of free radicals followed by DNA damage and loss of function of p53 tumor suppressor gene, result in uncontrolled proliferation of cells and formation of cancer. DCA — Deoxycholic acid; BCL10 — B cell lymphoma/leukemia 10 protein; NF-kB — Nuclear Factor kappa B; ROS/RNS — Reactive oxygen species/Reactive nitrogen species.

Mentions: Cancer is a major health concern in the developed and developing countries. On the World Cancer Day (February 4, 2014), the International Agency for Research on Cancer (IARC) published a worldwide report on cancer in 2012 which estimated about 14.1 million new cancer cases, 8.2 million deaths due to cancer and 32.6 million people living with cancer (International Agency for Research on Cancer, WHO [Internet], 2012). Combined effects of several factors such as genetic, environmental, life style can lead to cancer. One such factor for causing cancer is the cancer induced by microbes which estimates about 16.1% of the total cancer burden globally (De Martel et al., 2012). (See Fig. 1.)


Metagenomics: A new horizon in cancer research.

Banerjee J, Mishra N, Dhas Y - Meta Gene (2015)

Mechanism of oncogenesis induced due to change in the microbiota (Chang and Parsonnet, 2010). In this figure, environmental imbalances result in alteration of normal microbiota, subsequent formation of toxic metabolites, chronic inflammation, oncoproteins. The generation of free radicals followed by DNA damage and loss of function of p53 tumor suppressor gene, result in uncontrolled proliferation of cells and formation of cancer. DCA — Deoxycholic acid; BCL10 — B cell lymphoma/leukemia 10 protein; NF-kB — Nuclear Factor kappa B; ROS/RNS — Reactive oxygen species/Reactive nitrogen species.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4477109&req=5

f0005: Mechanism of oncogenesis induced due to change in the microbiota (Chang and Parsonnet, 2010). In this figure, environmental imbalances result in alteration of normal microbiota, subsequent formation of toxic metabolites, chronic inflammation, oncoproteins. The generation of free radicals followed by DNA damage and loss of function of p53 tumor suppressor gene, result in uncontrolled proliferation of cells and formation of cancer. DCA — Deoxycholic acid; BCL10 — B cell lymphoma/leukemia 10 protein; NF-kB — Nuclear Factor kappa B; ROS/RNS — Reactive oxygen species/Reactive nitrogen species.
Mentions: Cancer is a major health concern in the developed and developing countries. On the World Cancer Day (February 4, 2014), the International Agency for Research on Cancer (IARC) published a worldwide report on cancer in 2012 which estimated about 14.1 million new cancer cases, 8.2 million deaths due to cancer and 32.6 million people living with cancer (International Agency for Research on Cancer, WHO [Internet], 2012). Combined effects of several factors such as genetic, environmental, life style can lead to cancer. One such factor for causing cancer is the cancer induced by microbes which estimates about 16.1% of the total cancer burden globally (De Martel et al., 2012). (See Fig. 1.)

Bottom Line: About 16.1% of cancers are associated with microbial infection.Metagenomics is an equitable way of identifying and studying micro-organisms within their habitat.Different types of micro-organisms have been found to be linked to various types of cancers, thus, contributing significantly in understanding the disease at molecular level.

View Article: PubMed Central - PubMed

Affiliation: Symbiosis School of Biomedical Sciences, Symbiosis International University, Pune 412115, India.

ABSTRACT
Metagenomics has broadened the scope of targeting microbes responsible for inducing various types of cancers. About 16.1% of cancers are associated with microbial infection. Metagenomics is an equitable way of identifying and studying micro-organisms within their habitat. In cancer research, this approach has revolutionized the way of identifying, analyzing and targeting the microbial diversity present in the tissue specimens of cancer patients. The genomic analyses of these micro-organisms through next generation sequencing techniques invariably facilitate in recognizing the microbial population in biopsies and their evolutionary relationships with each other. In this review an attempt has been made to generate current metagenomic view on cancer microbiota. Different types of micro-organisms have been found to be linked to various types of cancers, thus, contributing significantly in understanding the disease at molecular level.

No MeSH data available.


Related in: MedlinePlus