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Connectome-Scale Assessments of Functional Connectivity in Children with Primary Monosymptomatic Nocturnal Enuresis.

Lei D, Ma J, Zhang J, Wang M, Zhang K, Chen F, Suo X, Gong Q, Du X - Biomed Res Int (2015)

Bottom Line: The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls.PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus.Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

View Article: PubMed Central - PubMed

Affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China ; MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China.

ABSTRACT
Primary monosymptomatic nocturnal enuresis (PMNE) is a common developmental disorder in children. Previous literature has suggested that PMNE not only is a micturition disorder but also is characterized by cerebral structure abnormalities and dysfunction. However, the biological mechanisms underlying the disease are not thoroughly understood. Graph theoretical analysis has provided a unique tool to reveal the intrinsic attributes of the connectivity patterns of a complex network from a global perspective. Resting-state fMRI was performed in 20 children with PMNE and 20 healthy controls. Brain networks were constructed by computing Pearson's correlations for blood oxygenation level-dependent temporal fluctuations among the 2 groups, followed by graph-based network analyses. The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls. PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus. Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

No MeSH data available.


Related in: MedlinePlus

The region pairs showing altered nodal centralities brain regions and functional connections in the PMNE patients. These connections formed a single connected network with 7 nodes and 10 connections, which was significantly (P < 0.05, corrected) abnormal in the patients. Edge in cyan: increased functional connections in the PMNE patients; edge in magenta: decreased functional connections in the PMNE patients. CUN, cuneus; LING, lingual gyrus; CAL, calcarine sulcus; STG, superior temporal gyrus; R, right hemisphere; P, posterior. The nodes and connections were mapped onto the cortical surfaces using the BrainNet Viewer package (http://www.nitrc.org/projects/bnv).
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fig3: The region pairs showing altered nodal centralities brain regions and functional connections in the PMNE patients. These connections formed a single connected network with 7 nodes and 10 connections, which was significantly (P < 0.05, corrected) abnormal in the patients. Edge in cyan: increased functional connections in the PMNE patients; edge in magenta: decreased functional connections in the PMNE patients. CUN, cuneus; LING, lingual gyrus; CAL, calcarine sulcus; STG, superior temporal gyrus; R, right hemisphere; P, posterior. The nodes and connections were mapped onto the cortical surfaces using the BrainNet Viewer package (http://www.nitrc.org/projects/bnv).

Mentions: We identified the brain regions showing significant between-group differences in at least one nodal metric (P < 0.05, FDR corrected). Compared with normal control subjects, the patients showed decreased nodal centralities in several brain regions, including the bilateral calcarine sulcus, the bilateral cuneus, the bilateral lingual gyri, and the right superior temporal gyrus (Figure 3, Table 1). There were no significantly increased nodal centralities.


Connectome-Scale Assessments of Functional Connectivity in Children with Primary Monosymptomatic Nocturnal Enuresis.

Lei D, Ma J, Zhang J, Wang M, Zhang K, Chen F, Suo X, Gong Q, Du X - Biomed Res Int (2015)

The region pairs showing altered nodal centralities brain regions and functional connections in the PMNE patients. These connections formed a single connected network with 7 nodes and 10 connections, which was significantly (P < 0.05, corrected) abnormal in the patients. Edge in cyan: increased functional connections in the PMNE patients; edge in magenta: decreased functional connections in the PMNE patients. CUN, cuneus; LING, lingual gyrus; CAL, calcarine sulcus; STG, superior temporal gyrus; R, right hemisphere; P, posterior. The nodes and connections were mapped onto the cortical surfaces using the BrainNet Viewer package (http://www.nitrc.org/projects/bnv).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477104&req=5

fig3: The region pairs showing altered nodal centralities brain regions and functional connections in the PMNE patients. These connections formed a single connected network with 7 nodes and 10 connections, which was significantly (P < 0.05, corrected) abnormal in the patients. Edge in cyan: increased functional connections in the PMNE patients; edge in magenta: decreased functional connections in the PMNE patients. CUN, cuneus; LING, lingual gyrus; CAL, calcarine sulcus; STG, superior temporal gyrus; R, right hemisphere; P, posterior. The nodes and connections were mapped onto the cortical surfaces using the BrainNet Viewer package (http://www.nitrc.org/projects/bnv).
Mentions: We identified the brain regions showing significant between-group differences in at least one nodal metric (P < 0.05, FDR corrected). Compared with normal control subjects, the patients showed decreased nodal centralities in several brain regions, including the bilateral calcarine sulcus, the bilateral cuneus, the bilateral lingual gyri, and the right superior temporal gyrus (Figure 3, Table 1). There were no significantly increased nodal centralities.

Bottom Line: The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls.PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus.Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

View Article: PubMed Central - PubMed

Affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China ; MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China.

ABSTRACT
Primary monosymptomatic nocturnal enuresis (PMNE) is a common developmental disorder in children. Previous literature has suggested that PMNE not only is a micturition disorder but also is characterized by cerebral structure abnormalities and dysfunction. However, the biological mechanisms underlying the disease are not thoroughly understood. Graph theoretical analysis has provided a unique tool to reveal the intrinsic attributes of the connectivity patterns of a complex network from a global perspective. Resting-state fMRI was performed in 20 children with PMNE and 20 healthy controls. Brain networks were constructed by computing Pearson's correlations for blood oxygenation level-dependent temporal fluctuations among the 2 groups, followed by graph-based network analyses. The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls. PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus. Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

No MeSH data available.


Related in: MedlinePlus