Limits...
Connectome-Scale Assessments of Functional Connectivity in Children with Primary Monosymptomatic Nocturnal Enuresis.

Lei D, Ma J, Zhang J, Wang M, Zhang K, Chen F, Suo X, Gong Q, Du X - Biomed Res Int (2015)

Bottom Line: The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls.PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus.Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

View Article: PubMed Central - PubMed

Affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China ; MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China.

ABSTRACT
Primary monosymptomatic nocturnal enuresis (PMNE) is a common developmental disorder in children. Previous literature has suggested that PMNE not only is a micturition disorder but also is characterized by cerebral structure abnormalities and dysfunction. However, the biological mechanisms underlying the disease are not thoroughly understood. Graph theoretical analysis has provided a unique tool to reveal the intrinsic attributes of the connectivity patterns of a complex network from a global perspective. Resting-state fMRI was performed in 20 children with PMNE and 20 healthy controls. Brain networks were constructed by computing Pearson's correlations for blood oxygenation level-dependent temporal fluctuations among the 2 groups, followed by graph-based network analyses. The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls. PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus. Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

No MeSH data available.


Related in: MedlinePlus

Differences in topological properties of functional brain networks between pediatric PMNE patients and trauma exposed non-PMNE controls. Significant differences were found in Cp (P = 0.0066), λ (P = 0.0147), Eglob (P = 0.0013), and Eloc (P = 0.0011) between pediatric PMNE patients and non-PMNE controls. ★: the black stars indicate the significantly statistical difference between the two groups (P < 0.05, uncorrected). Error bars denote standard deviations. PMNE: children with primary monosymptomatic nocturnal enuresis; HC: healthy children; Eglob: global efficiency; Eloc: local efficiency; Cp: clustering coefficient; γ: normalized clustering coefficient; λ: normalized characteristic path length; Lp: characteristic path length; σ: small-worldness.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4477104&req=5

fig2: Differences in topological properties of functional brain networks between pediatric PMNE patients and trauma exposed non-PMNE controls. Significant differences were found in Cp (P = 0.0066), λ (P = 0.0147), Eglob (P = 0.0013), and Eloc (P = 0.0011) between pediatric PMNE patients and non-PMNE controls. ★: the black stars indicate the significantly statistical difference between the two groups (P < 0.05, uncorrected). Error bars denote standard deviations. PMNE: children with primary monosymptomatic nocturnal enuresis; HC: healthy children; Eglob: global efficiency; Eloc: local efficiency; Cp: clustering coefficient; γ: normalized clustering coefficient; λ: normalized characteristic path length; Lp: characteristic path length; σ: small-worldness.

Mentions: The patient group showed significantly lower values for Cp (P = 0.007) and higher values for Lp (P = 0.0008). No significant (P > 0.05) differences were found in the λ, γ, or σ. In terms of network efficiency, the comparisons revealed significant decreases in both Eglob (P = 0.001) and Eloc (P = 0.001) in the functional brain networks of the patients compared with the healthy controls (Figure 2).


Connectome-Scale Assessments of Functional Connectivity in Children with Primary Monosymptomatic Nocturnal Enuresis.

Lei D, Ma J, Zhang J, Wang M, Zhang K, Chen F, Suo X, Gong Q, Du X - Biomed Res Int (2015)

Differences in topological properties of functional brain networks between pediatric PMNE patients and trauma exposed non-PMNE controls. Significant differences were found in Cp (P = 0.0066), λ (P = 0.0147), Eglob (P = 0.0013), and Eloc (P = 0.0011) between pediatric PMNE patients and non-PMNE controls. ★: the black stars indicate the significantly statistical difference between the two groups (P < 0.05, uncorrected). Error bars denote standard deviations. PMNE: children with primary monosymptomatic nocturnal enuresis; HC: healthy children; Eglob: global efficiency; Eloc: local efficiency; Cp: clustering coefficient; γ: normalized clustering coefficient; λ: normalized characteristic path length; Lp: characteristic path length; σ: small-worldness.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477104&req=5

fig2: Differences in topological properties of functional brain networks between pediatric PMNE patients and trauma exposed non-PMNE controls. Significant differences were found in Cp (P = 0.0066), λ (P = 0.0147), Eglob (P = 0.0013), and Eloc (P = 0.0011) between pediatric PMNE patients and non-PMNE controls. ★: the black stars indicate the significantly statistical difference between the two groups (P < 0.05, uncorrected). Error bars denote standard deviations. PMNE: children with primary monosymptomatic nocturnal enuresis; HC: healthy children; Eglob: global efficiency; Eloc: local efficiency; Cp: clustering coefficient; γ: normalized clustering coefficient; λ: normalized characteristic path length; Lp: characteristic path length; σ: small-worldness.
Mentions: The patient group showed significantly lower values for Cp (P = 0.007) and higher values for Lp (P = 0.0008). No significant (P > 0.05) differences were found in the λ, γ, or σ. In terms of network efficiency, the comparisons revealed significant decreases in both Eglob (P = 0.001) and Eloc (P = 0.001) in the functional brain networks of the patients compared with the healthy controls (Figure 2).

Bottom Line: The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls.PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus.Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

View Article: PubMed Central - PubMed

Affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China ; MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China.

ABSTRACT
Primary monosymptomatic nocturnal enuresis (PMNE) is a common developmental disorder in children. Previous literature has suggested that PMNE not only is a micturition disorder but also is characterized by cerebral structure abnormalities and dysfunction. However, the biological mechanisms underlying the disease are not thoroughly understood. Graph theoretical analysis has provided a unique tool to reveal the intrinsic attributes of the connectivity patterns of a complex network from a global perspective. Resting-state fMRI was performed in 20 children with PMNE and 20 healthy controls. Brain networks were constructed by computing Pearson's correlations for blood oxygenation level-dependent temporal fluctuations among the 2 groups, followed by graph-based network analyses. The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls. PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus. Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

No MeSH data available.


Related in: MedlinePlus