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Connectome-Scale Assessments of Functional Connectivity in Children with Primary Monosymptomatic Nocturnal Enuresis.

Lei D, Ma J, Zhang J, Wang M, Zhang K, Chen F, Suo X, Gong Q, Du X - Biomed Res Int (2015)

Bottom Line: The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls.PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus.Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

View Article: PubMed Central - PubMed

Affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China ; MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China.

ABSTRACT
Primary monosymptomatic nocturnal enuresis (PMNE) is a common developmental disorder in children. Previous literature has suggested that PMNE not only is a micturition disorder but also is characterized by cerebral structure abnormalities and dysfunction. However, the biological mechanisms underlying the disease are not thoroughly understood. Graph theoretical analysis has provided a unique tool to reveal the intrinsic attributes of the connectivity patterns of a complex network from a global perspective. Resting-state fMRI was performed in 20 children with PMNE and 20 healthy controls. Brain networks were constructed by computing Pearson's correlations for blood oxygenation level-dependent temporal fluctuations among the 2 groups, followed by graph-based network analyses. The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls. PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus. Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

No MeSH data available.


Related in: MedlinePlus

The key small-world parameters of functional network as a function of sparsity threshold. Both PMNE group and non-PMNE group showed normalized Cp larger than 1 and normalized Lp approximately equal to 1, indicating both groups exhibited a small-world topology. PMNE: children with primary monosymptomatic nocturnal enuresis; HC: healthy children; Cp: clustering coefficient; Lp: characteristic path length.
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fig1: The key small-world parameters of functional network as a function of sparsity threshold. Both PMNE group and non-PMNE group showed normalized Cp larger than 1 and normalized Lp approximately equal to 1, indicating both groups exhibited a small-world topology. PMNE: children with primary monosymptomatic nocturnal enuresis; HC: healthy children; Cp: clustering coefficient; Lp: characteristic path length.

Mentions: The whole-brain connectome of both the PMNE and control groups exhibited typical features of small-world topology; that is, compared with matched random networks, the functional brain networks had higher clustering coefficients (Cp) but similar characteristic path length (Lp) (Figure 1).


Connectome-Scale Assessments of Functional Connectivity in Children with Primary Monosymptomatic Nocturnal Enuresis.

Lei D, Ma J, Zhang J, Wang M, Zhang K, Chen F, Suo X, Gong Q, Du X - Biomed Res Int (2015)

The key small-world parameters of functional network as a function of sparsity threshold. Both PMNE group and non-PMNE group showed normalized Cp larger than 1 and normalized Lp approximately equal to 1, indicating both groups exhibited a small-world topology. PMNE: children with primary monosymptomatic nocturnal enuresis; HC: healthy children; Cp: clustering coefficient; Lp: characteristic path length.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477104&req=5

fig1: The key small-world parameters of functional network as a function of sparsity threshold. Both PMNE group and non-PMNE group showed normalized Cp larger than 1 and normalized Lp approximately equal to 1, indicating both groups exhibited a small-world topology. PMNE: children with primary monosymptomatic nocturnal enuresis; HC: healthy children; Cp: clustering coefficient; Lp: characteristic path length.
Mentions: The whole-brain connectome of both the PMNE and control groups exhibited typical features of small-world topology; that is, compared with matched random networks, the functional brain networks had higher clustering coefficients (Cp) but similar characteristic path length (Lp) (Figure 1).

Bottom Line: The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls.PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus.Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

View Article: PubMed Central - PubMed

Affiliation: Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China ; MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610044, China.

ABSTRACT
Primary monosymptomatic nocturnal enuresis (PMNE) is a common developmental disorder in children. Previous literature has suggested that PMNE not only is a micturition disorder but also is characterized by cerebral structure abnormalities and dysfunction. However, the biological mechanisms underlying the disease are not thoroughly understood. Graph theoretical analysis has provided a unique tool to reveal the intrinsic attributes of the connectivity patterns of a complex network from a global perspective. Resting-state fMRI was performed in 20 children with PMNE and 20 healthy controls. Brain networks were constructed by computing Pearson's correlations for blood oxygenation level-dependent temporal fluctuations among the 2 groups, followed by graph-based network analyses. The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls. PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus. Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.

No MeSH data available.


Related in: MedlinePlus