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Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats.

Ortiz-Avila O, Esquivel-Martínez M, Olmos-Orizaba BE, Saavedra-Molina A, Rodriguez-Orozco AR, Cortés-Rojo C - J Diabetes Res (2015)

Bottom Line: Although the pathophysiology of diabetic encephalopathy remains to be clarified, oxidative stress and mitochondrial dysfunction play a crucial role in the pathogenesis of chronic diabetic complications.Avocado oil also decreased ROS levels and lipid peroxidation and improved the GSH/GSSG ratio as well.These results demonstrate that avocado oil supplementation prevents brain mitochondrial dysfunction induced by diabetes in association with decreased oxidative stress.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, 58030 Morelia, MICH, Mexico.

ABSTRACT
Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy remains to be clarified, oxidative stress and mitochondrial dysfunction play a crucial role in the pathogenesis of chronic diabetic complications. Taking this into consideration, the aim of this work was to evaluate the effects of 90-day avocado oil intake in brain mitochondrial function and oxidative status in streptozotocin-induced diabetic rats (STZ rats). Avocado oil improves brain mitochondrial function in diabetic rats preventing impairment of mitochondrial respiration and mitochondrial membrane potential (ΔΨ m ), besides increasing complex III activity. Avocado oil also decreased ROS levels and lipid peroxidation and improved the GSH/GSSG ratio as well. These results demonstrate that avocado oil supplementation prevents brain mitochondrial dysfunction induced by diabetes in association with decreased oxidative stress.

No MeSH data available.


Related in: MedlinePlus

Effect of avocado oil on TBARS of brain mitochondria. Data are the mean ± EE of (n = 4). ∗∗p < 0.01 compared with brain control mitochondria.
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fig5: Effect of avocado oil on TBARS of brain mitochondria. Data are the mean ± EE of (n = 4). ∗∗p < 0.01 compared with brain control mitochondria.

Mentions: Lipid peroxidation and GSH/GSSG ratios were analyzed as markers of oxidative stress to test whether enhanced ROS levels in diabetic rats and the protection conferred by avocado oil were parallel to changes in oxidative stress. In comparison to control rats, the levels of TBARS were similar in mitochondria from diabetic rats (Figure 5). However, avocado oil decreased the levels of lipid peroxidation in both control and diabetic groups, although this effect was statistically significant only in the diabetic group (65%).


Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats.

Ortiz-Avila O, Esquivel-Martínez M, Olmos-Orizaba BE, Saavedra-Molina A, Rodriguez-Orozco AR, Cortés-Rojo C - J Diabetes Res (2015)

Effect of avocado oil on TBARS of brain mitochondria. Data are the mean ± EE of (n = 4). ∗∗p < 0.01 compared with brain control mitochondria.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477098&req=5

fig5: Effect of avocado oil on TBARS of brain mitochondria. Data are the mean ± EE of (n = 4). ∗∗p < 0.01 compared with brain control mitochondria.
Mentions: Lipid peroxidation and GSH/GSSG ratios were analyzed as markers of oxidative stress to test whether enhanced ROS levels in diabetic rats and the protection conferred by avocado oil were parallel to changes in oxidative stress. In comparison to control rats, the levels of TBARS were similar in mitochondria from diabetic rats (Figure 5). However, avocado oil decreased the levels of lipid peroxidation in both control and diabetic groups, although this effect was statistically significant only in the diabetic group (65%).

Bottom Line: Although the pathophysiology of diabetic encephalopathy remains to be clarified, oxidative stress and mitochondrial dysfunction play a crucial role in the pathogenesis of chronic diabetic complications.Avocado oil also decreased ROS levels and lipid peroxidation and improved the GSH/GSSG ratio as well.These results demonstrate that avocado oil supplementation prevents brain mitochondrial dysfunction induced by diabetes in association with decreased oxidative stress.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, 58030 Morelia, MICH, Mexico.

ABSTRACT
Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy remains to be clarified, oxidative stress and mitochondrial dysfunction play a crucial role in the pathogenesis of chronic diabetic complications. Taking this into consideration, the aim of this work was to evaluate the effects of 90-day avocado oil intake in brain mitochondrial function and oxidative status in streptozotocin-induced diabetic rats (STZ rats). Avocado oil improves brain mitochondrial function in diabetic rats preventing impairment of mitochondrial respiration and mitochondrial membrane potential (ΔΨ m ), besides increasing complex III activity. Avocado oil also decreased ROS levels and lipid peroxidation and improved the GSH/GSSG ratio as well. These results demonstrate that avocado oil supplementation prevents brain mitochondrial dysfunction induced by diabetes in association with decreased oxidative stress.

No MeSH data available.


Related in: MedlinePlus