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Neurophysiological modeling of bladder afferent activity in the rat overactive bladder model.

Choudhary M, van Asselt E, van Mastrigt R, Clavica F - J Physiol Sci (2015)

Bottom Line: The afferent activity in the filling phase and the slope, i.e., the sensitivity of the afferent fibers to pressure changes in the post-void relaxation phase, were found to be significantly higher in AA than in saline measurements, while the offset (nerve activity at pressure ~0) and maximum pressure were comparable.We have thus shown, for the first time, that the sensitivity of afferent fibers in the OAB can be studied without cutting nerves or preparation of single fibers.We conclude that bladder overactivity induced by AA in rats is neurogenic in origin and is caused by increased sensitivity of afferent sensors in the bladder wall.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Sector FURORE, Erasmus MC, Room EE1630, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands, m.choudhary@erasmusmc.nl.

ABSTRACT
The overactive bladder (OAB) is a syndrome-based urinary dysfunction characterized by "urgency, with or without urge incontinence, usually with frequency and nocturia". Earlier we developed a mathematical model of bladder nerve activity during voiding in anesthetized rats and found that the nerve activity in the relaxation phase of voiding contractions was all afferent. In the present study, we applied this mathematical model to an acetic acid (AA) rat model of bladder overactivity to study the sensitivity of afferent fibers in intact nerves to bladder pressure and volume changes. The afferent activity in the filling phase and the slope, i.e., the sensitivity of the afferent fibers to pressure changes in the post-void relaxation phase, were found to be significantly higher in AA than in saline measurements, while the offset (nerve activity at pressure ~0) and maximum pressure were comparable. We have thus shown, for the first time, that the sensitivity of afferent fibers in the OAB can be studied without cutting nerves or preparation of single fibers. We conclude that bladder overactivity induced by AA in rats is neurogenic in origin and is caused by increased sensitivity of afferent sensors in the bladder wall.

No MeSH data available.


Related in: MedlinePlus

Pressure development during bladder filling. Bladder pressure recorded during one complete voiding cycle of a rat. t = 0 represents the start of bladder filling, at t1 − t2 voiding takes place and t > t2 represents the relaxation phase
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Fig2: Pressure development during bladder filling. Bladder pressure recorded during one complete voiding cycle of a rat. t = 0 represents the start of bladder filling, at t1 − t2 voiding takes place and t > t2 represents the relaxation phase

Mentions: The whole micturition cycle shown in Fig. 2 was divided into three phases:Fig. 2


Neurophysiological modeling of bladder afferent activity in the rat overactive bladder model.

Choudhary M, van Asselt E, van Mastrigt R, Clavica F - J Physiol Sci (2015)

Pressure development during bladder filling. Bladder pressure recorded during one complete voiding cycle of a rat. t = 0 represents the start of bladder filling, at t1 − t2 voiding takes place and t > t2 represents the relaxation phase
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477068&req=5

Fig2: Pressure development during bladder filling. Bladder pressure recorded during one complete voiding cycle of a rat. t = 0 represents the start of bladder filling, at t1 − t2 voiding takes place and t > t2 represents the relaxation phase
Mentions: The whole micturition cycle shown in Fig. 2 was divided into three phases:Fig. 2

Bottom Line: The afferent activity in the filling phase and the slope, i.e., the sensitivity of the afferent fibers to pressure changes in the post-void relaxation phase, were found to be significantly higher in AA than in saline measurements, while the offset (nerve activity at pressure ~0) and maximum pressure were comparable.We have thus shown, for the first time, that the sensitivity of afferent fibers in the OAB can be studied without cutting nerves or preparation of single fibers.We conclude that bladder overactivity induced by AA in rats is neurogenic in origin and is caused by increased sensitivity of afferent sensors in the bladder wall.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Sector FURORE, Erasmus MC, Room EE1630, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands, m.choudhary@erasmusmc.nl.

ABSTRACT
The overactive bladder (OAB) is a syndrome-based urinary dysfunction characterized by "urgency, with or without urge incontinence, usually with frequency and nocturia". Earlier we developed a mathematical model of bladder nerve activity during voiding in anesthetized rats and found that the nerve activity in the relaxation phase of voiding contractions was all afferent. In the present study, we applied this mathematical model to an acetic acid (AA) rat model of bladder overactivity to study the sensitivity of afferent fibers in intact nerves to bladder pressure and volume changes. The afferent activity in the filling phase and the slope, i.e., the sensitivity of the afferent fibers to pressure changes in the post-void relaxation phase, were found to be significantly higher in AA than in saline measurements, while the offset (nerve activity at pressure ~0) and maximum pressure were comparable. We have thus shown, for the first time, that the sensitivity of afferent fibers in the OAB can be studied without cutting nerves or preparation of single fibers. We conclude that bladder overactivity induced by AA in rats is neurogenic in origin and is caused by increased sensitivity of afferent sensors in the bladder wall.

No MeSH data available.


Related in: MedlinePlus