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Neural Correlates of Associative Memory in the Elderly: A Resting-State Functional MRI Study.

Ren W, Li R, Zheng Z, Li J - Biomed Res Int (2015)

Bottom Line: The neural correlates of associative memory in healthy older adults were investigated by examining the correlation of associative memory performance with spontaneous brain oscillations.Correlations between the amplitude of low-frequency fluctuations (ALFF) as well as fractional ALFF (fALFF) in the whole brain and PALT scores were calculated.We found that spontaneous activity as indexed by both ALFF and fALFF in the parahippocampal gyrus (PHG) was significantly positively correlated with associative memory performance, suggesting that the PHG plays a critical role in associative memory in older people.

View Article: PubMed Central - PubMed

Affiliation: Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China ; University of Chinese Academy of Sciences, Beijing 100101, China.

ABSTRACT
The neural correlates of associative memory in healthy older adults were investigated by examining the correlation of associative memory performance with spontaneous brain oscillations. Eighty healthy older adults underwent a resting-state functional MRI and took a paired-associative learning test (PALT). Correlations between the amplitude of low-frequency fluctuations (ALFF) as well as fractional ALFF (fALFF) in the whole brain and PALT scores were calculated. We found that spontaneous activity as indexed by both ALFF and fALFF in the parahippocampal gyrus (PHG) was significantly positively correlated with associative memory performance, suggesting that the PHG plays a critical role in associative memory in older people.

No MeSH data available.


Related in: MedlinePlus

Scatter plots of the significant relationship between PALT scores and ALFF as well as fALFF values in the right PHG with age, gender, and education as covariates. Each dot represents data from one participant.
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Related In: Results  -  Collection


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fig2: Scatter plots of the significant relationship between PALT scores and ALFF as well as fALFF values in the right PHG with age, gender, and education as covariates. Each dot represents data from one participant.

Mentions: As the results of the correlation analyses, spontaneous activity in the right PHG was demonstrated to be robustly correlated with associative memory performance assessed by PALT. Scatter plots of PALT scores versus ALFF/fALFF values were displayed to illustrate the relationship between spontaneous oscillations in the right PHG and PALT scores with age, education, and gender taken as covariates (Figure 2). ALFF/fALFF values under/over 3 standard deviations away from the mean value of the sample were identified as outliers and removed from the data set. Thus the ALFF value from one participant was removed during analyses. The results demonstrated that PALT scores were positively correlated with ALFF (r = 0.258, P = 0.023) and fALFF (r = 0.359, P = 0.001) in the right PHG.


Neural Correlates of Associative Memory in the Elderly: A Resting-State Functional MRI Study.

Ren W, Li R, Zheng Z, Li J - Biomed Res Int (2015)

Scatter plots of the significant relationship between PALT scores and ALFF as well as fALFF values in the right PHG with age, gender, and education as covariates. Each dot represents data from one participant.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477061&req=5

fig2: Scatter plots of the significant relationship between PALT scores and ALFF as well as fALFF values in the right PHG with age, gender, and education as covariates. Each dot represents data from one participant.
Mentions: As the results of the correlation analyses, spontaneous activity in the right PHG was demonstrated to be robustly correlated with associative memory performance assessed by PALT. Scatter plots of PALT scores versus ALFF/fALFF values were displayed to illustrate the relationship between spontaneous oscillations in the right PHG and PALT scores with age, education, and gender taken as covariates (Figure 2). ALFF/fALFF values under/over 3 standard deviations away from the mean value of the sample were identified as outliers and removed from the data set. Thus the ALFF value from one participant was removed during analyses. The results demonstrated that PALT scores were positively correlated with ALFF (r = 0.258, P = 0.023) and fALFF (r = 0.359, P = 0.001) in the right PHG.

Bottom Line: The neural correlates of associative memory in healthy older adults were investigated by examining the correlation of associative memory performance with spontaneous brain oscillations.Correlations between the amplitude of low-frequency fluctuations (ALFF) as well as fractional ALFF (fALFF) in the whole brain and PALT scores were calculated.We found that spontaneous activity as indexed by both ALFF and fALFF in the parahippocampal gyrus (PHG) was significantly positively correlated with associative memory performance, suggesting that the PHG plays a critical role in associative memory in older people.

View Article: PubMed Central - PubMed

Affiliation: Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China ; University of Chinese Academy of Sciences, Beijing 100101, China.

ABSTRACT
The neural correlates of associative memory in healthy older adults were investigated by examining the correlation of associative memory performance with spontaneous brain oscillations. Eighty healthy older adults underwent a resting-state functional MRI and took a paired-associative learning test (PALT). Correlations between the amplitude of low-frequency fluctuations (ALFF) as well as fractional ALFF (fALFF) in the whole brain and PALT scores were calculated. We found that spontaneous activity as indexed by both ALFF and fALFF in the parahippocampal gyrus (PHG) was significantly positively correlated with associative memory performance, suggesting that the PHG plays a critical role in associative memory in older people.

No MeSH data available.


Related in: MedlinePlus