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Neural Correlates of Associative Memory in the Elderly: A Resting-State Functional MRI Study.

Ren W, Li R, Zheng Z, Li J - Biomed Res Int (2015)

Bottom Line: The neural correlates of associative memory in healthy older adults were investigated by examining the correlation of associative memory performance with spontaneous brain oscillations.Correlations between the amplitude of low-frequency fluctuations (ALFF) as well as fractional ALFF (fALFF) in the whole brain and PALT scores were calculated.We found that spontaneous activity as indexed by both ALFF and fALFF in the parahippocampal gyrus (PHG) was significantly positively correlated with associative memory performance, suggesting that the PHG plays a critical role in associative memory in older people.

View Article: PubMed Central - PubMed

Affiliation: Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China ; University of Chinese Academy of Sciences, Beijing 100101, China.

ABSTRACT
The neural correlates of associative memory in healthy older adults were investigated by examining the correlation of associative memory performance with spontaneous brain oscillations. Eighty healthy older adults underwent a resting-state functional MRI and took a paired-associative learning test (PALT). Correlations between the amplitude of low-frequency fluctuations (ALFF) as well as fractional ALFF (fALFF) in the whole brain and PALT scores were calculated. We found that spontaneous activity as indexed by both ALFF and fALFF in the parahippocampal gyrus (PHG) was significantly positively correlated with associative memory performance, suggesting that the PHG plays a critical role in associative memory in older people.

No MeSH data available.


Related in: MedlinePlus

Regional oscillations and associative memory correlation analyses. (A) Statistical map for the correlations between performance on the PALT and ALFF in the bilateral PHG (a, b), left insula (c), right IFG (d), and right ITG (e). (B) Statistical map for the correlations between performance on the PALT and fractional ALFF in the right PHG/STG (f), right IPL (g), and right SMA/SFG (h). The correlation values are indicated using the color scales on the right.
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fig1: Regional oscillations and associative memory correlation analyses. (A) Statistical map for the correlations between performance on the PALT and ALFF in the bilateral PHG (a, b), left insula (c), right IFG (d), and right ITG (e). (B) Statistical map for the correlations between performance on the PALT and fractional ALFF in the right PHG/STG (f), right IPL (g), and right SMA/SFG (h). The correlation values are indicated using the color scales on the right.

Mentions: Voxelwise correlation analyses showed that resting-state ALFF values correlated with PALT scores in a number of brain regions (Figure 1(A), Table 2). Specifically, the ALFF values positively correlated with PALT scores in the bilateral parahippocampal gyri (PHG) and left insula, while negative correlations were found between them in the right inferior temporal gyrus (ITG) and right inferior frontal gyrus (IFG).


Neural Correlates of Associative Memory in the Elderly: A Resting-State Functional MRI Study.

Ren W, Li R, Zheng Z, Li J - Biomed Res Int (2015)

Regional oscillations and associative memory correlation analyses. (A) Statistical map for the correlations between performance on the PALT and ALFF in the bilateral PHG (a, b), left insula (c), right IFG (d), and right ITG (e). (B) Statistical map for the correlations between performance on the PALT and fractional ALFF in the right PHG/STG (f), right IPL (g), and right SMA/SFG (h). The correlation values are indicated using the color scales on the right.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4477061&req=5

fig1: Regional oscillations and associative memory correlation analyses. (A) Statistical map for the correlations between performance on the PALT and ALFF in the bilateral PHG (a, b), left insula (c), right IFG (d), and right ITG (e). (B) Statistical map for the correlations between performance on the PALT and fractional ALFF in the right PHG/STG (f), right IPL (g), and right SMA/SFG (h). The correlation values are indicated using the color scales on the right.
Mentions: Voxelwise correlation analyses showed that resting-state ALFF values correlated with PALT scores in a number of brain regions (Figure 1(A), Table 2). Specifically, the ALFF values positively correlated with PALT scores in the bilateral parahippocampal gyri (PHG) and left insula, while negative correlations were found between them in the right inferior temporal gyrus (ITG) and right inferior frontal gyrus (IFG).

Bottom Line: The neural correlates of associative memory in healthy older adults were investigated by examining the correlation of associative memory performance with spontaneous brain oscillations.Correlations between the amplitude of low-frequency fluctuations (ALFF) as well as fractional ALFF (fALFF) in the whole brain and PALT scores were calculated.We found that spontaneous activity as indexed by both ALFF and fALFF in the parahippocampal gyrus (PHG) was significantly positively correlated with associative memory performance, suggesting that the PHG plays a critical role in associative memory in older people.

View Article: PubMed Central - PubMed

Affiliation: Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China ; University of Chinese Academy of Sciences, Beijing 100101, China.

ABSTRACT
The neural correlates of associative memory in healthy older adults were investigated by examining the correlation of associative memory performance with spontaneous brain oscillations. Eighty healthy older adults underwent a resting-state functional MRI and took a paired-associative learning test (PALT). Correlations between the amplitude of low-frequency fluctuations (ALFF) as well as fractional ALFF (fALFF) in the whole brain and PALT scores were calculated. We found that spontaneous activity as indexed by both ALFF and fALFF in the parahippocampal gyrus (PHG) was significantly positively correlated with associative memory performance, suggesting that the PHG plays a critical role in associative memory in older people.

No MeSH data available.


Related in: MedlinePlus