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Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.

Chen M, Tang W, Hou L, Liu R, Dong Z, Han X, Zhang X, Wan D, Yu S - PLoS ONE (2015)

Bottom Line: We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis.The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China; Department of Neurology, the First People's Hospital of Nanyang, Nanyang, Henan Province, China.

ABSTRACT

Background and objective: Conflicting data have been reported on the association between tumor necrosis factor (TNF) -308G>A and nitric oxide synthase 3 (NOS3) +894G>T polymorphisms and migraine. We performed a meta-analysis of case-control studies to evaluate whether the TNF -308G>A and NOS3 +894G>T polymorphisms confer genetic susceptibility to migraine.

Method: We performed an updated meta-analysis for TNF -308G>A and a meta-analysis for NOS3 +894G>T based on studies published up to July 2014. We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.

Results: Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis. Neither indicated overall associations between gene polymorphisms and migraine risk. Subgroup analyses suggested that the "A" allele of the TNF -308G>A variant increases the risk of migraine among non-Caucasians (dominant model: pooled OR = 1.82; 95% CI 1.15 - 2.87). The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians. Subgroup analyses suggested that the "T" allele of the NOS3 +894G>T variant increases the risk of migraine among non-Caucasians (co-dominant model: pooled OR = 2.10; 95% CI 1.14 - 3.88).

Conclusions: Our findings appear to support the hypothesis that the TNF -308G>A polymorphism may act as a genetic susceptibility factor for migraine among non-Caucasians and that the NOS3 +894G>T polymorphism may modulate the risk of migraine among non-Caucasians.

No MeSH data available.


Related in: MedlinePlus

Begg’s funnel plots for genetic polymorphisms.A: Begg’s funnel plot for the TNF –308G>A polymorphism. B: Begg’s funnel plot for the NOS3 +894G>T polymorphism.
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pone.0129372.g006: Begg’s funnel plots for genetic polymorphisms.A: Begg’s funnel plot for the TNF –308G>A polymorphism. B: Begg’s funnel plot for the NOS3 +894G>T polymorphism.

Mentions: Publication bias was determined using Begg’s funnel plots and Egger’s test. Neither Egger’s test nor Begg’s funnel plots indicated any significant publication bias (P = 0.699 and 1.000, respectively, for TNF –308G>A, P = 0.707 and 0.508, respectively, for NOS3 +894G>T) (Fig 6A and 6B).


Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.

Chen M, Tang W, Hou L, Liu R, Dong Z, Han X, Zhang X, Wan D, Yu S - PLoS ONE (2015)

Begg’s funnel plots for genetic polymorphisms.A: Begg’s funnel plot for the TNF –308G>A polymorphism. B: Begg’s funnel plot for the NOS3 +894G>T polymorphism.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476787&req=5

pone.0129372.g006: Begg’s funnel plots for genetic polymorphisms.A: Begg’s funnel plot for the TNF –308G>A polymorphism. B: Begg’s funnel plot for the NOS3 +894G>T polymorphism.
Mentions: Publication bias was determined using Begg’s funnel plots and Egger’s test. Neither Egger’s test nor Begg’s funnel plots indicated any significant publication bias (P = 0.699 and 1.000, respectively, for TNF –308G>A, P = 0.707 and 0.508, respectively, for NOS3 +894G>T) (Fig 6A and 6B).

Bottom Line: We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis.The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China; Department of Neurology, the First People's Hospital of Nanyang, Nanyang, Henan Province, China.

ABSTRACT

Background and objective: Conflicting data have been reported on the association between tumor necrosis factor (TNF) -308G>A and nitric oxide synthase 3 (NOS3) +894G>T polymorphisms and migraine. We performed a meta-analysis of case-control studies to evaluate whether the TNF -308G>A and NOS3 +894G>T polymorphisms confer genetic susceptibility to migraine.

Method: We performed an updated meta-analysis for TNF -308G>A and a meta-analysis for NOS3 +894G>T based on studies published up to July 2014. We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.

Results: Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis. Neither indicated overall associations between gene polymorphisms and migraine risk. Subgroup analyses suggested that the "A" allele of the TNF -308G>A variant increases the risk of migraine among non-Caucasians (dominant model: pooled OR = 1.82; 95% CI 1.15 - 2.87). The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians. Subgroup analyses suggested that the "T" allele of the NOS3 +894G>T variant increases the risk of migraine among non-Caucasians (co-dominant model: pooled OR = 2.10; 95% CI 1.14 - 3.88).

Conclusions: Our findings appear to support the hypothesis that the TNF -308G>A polymorphism may act as a genetic susceptibility factor for migraine among non-Caucasians and that the NOS3 +894G>T polymorphism may modulate the risk of migraine among non-Caucasians.

No MeSH data available.


Related in: MedlinePlus