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Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.

Chen M, Tang W, Hou L, Liu R, Dong Z, Han X, Zhang X, Wan D, Yu S - PLoS ONE (2015)

Bottom Line: We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis.The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China; Department of Neurology, the First People's Hospital of Nanyang, Nanyang, Henan Province, China.

ABSTRACT

Background and objective: Conflicting data have been reported on the association between tumor necrosis factor (TNF) -308G>A and nitric oxide synthase 3 (NOS3) +894G>T polymorphisms and migraine. We performed a meta-analysis of case-control studies to evaluate whether the TNF -308G>A and NOS3 +894G>T polymorphisms confer genetic susceptibility to migraine.

Method: We performed an updated meta-analysis for TNF -308G>A and a meta-analysis for NOS3 +894G>T based on studies published up to July 2014. We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.

Results: Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis. Neither indicated overall associations between gene polymorphisms and migraine risk. Subgroup analyses suggested that the "A" allele of the TNF -308G>A variant increases the risk of migraine among non-Caucasians (dominant model: pooled OR = 1.82; 95% CI 1.15 - 2.87). The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians. Subgroup analyses suggested that the "T" allele of the NOS3 +894G>T variant increases the risk of migraine among non-Caucasians (co-dominant model: pooled OR = 2.10; 95% CI 1.14 - 3.88).

Conclusions: Our findings appear to support the hypothesis that the TNF -308G>A polymorphism may act as a genetic susceptibility factor for migraine among non-Caucasians and that the NOS3 +894G>T polymorphism may modulate the risk of migraine among non-Caucasians.

No MeSH data available.


Related in: MedlinePlus

One-way sensitivity analyses of the associations between genetic polymorphisms and migraine risk.A: One-way sensitivity analysis of the association between the TNF –308G>A polymorphism and migraine risk under the GA vs. GG model. B: One-way sensitivity analysis of the association between the NOS3 +894G>T polymorphism and migraine risk under the T vs. G model.
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pone.0129372.g005: One-way sensitivity analyses of the associations between genetic polymorphisms and migraine risk.A: One-way sensitivity analysis of the association between the TNF –308G>A polymorphism and migraine risk under the GA vs. GG model. B: One-way sensitivity analysis of the association between the NOS3 +894G>T polymorphism and migraine risk under the T vs. G model.

Mentions: There was no significant heterogeneity among studies of TNF –308G>A polymorphism and MA (P > 0.10 for all genetic models). Nevertheless, the reverse effects were observed in studies of the TNF –308G>A polymorphism and migraine without aura (MO). Using Galbraith plots, we identified individual studies as important sources of heterogeneity [26, 28, 30, 31, 51], as shown in S1A and S1B Fig Among the five studies that were sources of heterogeneity, one had a low NOS scale, indicating low quality [51], and the other three had study populations with heterogeneous ethnic backgrounds [28, 30, 31]. Therefore, we performed sensitivity analyses by excluding studies that fell outside the margin set by the z score ± 2 standard deviation. We conducted sensitivity analysis to explore the potential sources of heterogeneity in the overall results. The initial ORs were not significantly influenced by sequential removal of each study from the total analysis (Fig 5A and 5B).


Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.

Chen M, Tang W, Hou L, Liu R, Dong Z, Han X, Zhang X, Wan D, Yu S - PLoS ONE (2015)

One-way sensitivity analyses of the associations between genetic polymorphisms and migraine risk.A: One-way sensitivity analysis of the association between the TNF –308G>A polymorphism and migraine risk under the GA vs. GG model. B: One-way sensitivity analysis of the association between the NOS3 +894G>T polymorphism and migraine risk under the T vs. G model.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476787&req=5

pone.0129372.g005: One-way sensitivity analyses of the associations between genetic polymorphisms and migraine risk.A: One-way sensitivity analysis of the association between the TNF –308G>A polymorphism and migraine risk under the GA vs. GG model. B: One-way sensitivity analysis of the association between the NOS3 +894G>T polymorphism and migraine risk under the T vs. G model.
Mentions: There was no significant heterogeneity among studies of TNF –308G>A polymorphism and MA (P > 0.10 for all genetic models). Nevertheless, the reverse effects were observed in studies of the TNF –308G>A polymorphism and migraine without aura (MO). Using Galbraith plots, we identified individual studies as important sources of heterogeneity [26, 28, 30, 31, 51], as shown in S1A and S1B Fig Among the five studies that were sources of heterogeneity, one had a low NOS scale, indicating low quality [51], and the other three had study populations with heterogeneous ethnic backgrounds [28, 30, 31]. Therefore, we performed sensitivity analyses by excluding studies that fell outside the margin set by the z score ± 2 standard deviation. We conducted sensitivity analysis to explore the potential sources of heterogeneity in the overall results. The initial ORs were not significantly influenced by sequential removal of each study from the total analysis (Fig 5A and 5B).

Bottom Line: We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis.The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China; Department of Neurology, the First People's Hospital of Nanyang, Nanyang, Henan Province, China.

ABSTRACT

Background and objective: Conflicting data have been reported on the association between tumor necrosis factor (TNF) -308G>A and nitric oxide synthase 3 (NOS3) +894G>T polymorphisms and migraine. We performed a meta-analysis of case-control studies to evaluate whether the TNF -308G>A and NOS3 +894G>T polymorphisms confer genetic susceptibility to migraine.

Method: We performed an updated meta-analysis for TNF -308G>A and a meta-analysis for NOS3 +894G>T based on studies published up to July 2014. We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.

Results: Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis. Neither indicated overall associations between gene polymorphisms and migraine risk. Subgroup analyses suggested that the "A" allele of the TNF -308G>A variant increases the risk of migraine among non-Caucasians (dominant model: pooled OR = 1.82; 95% CI 1.15 - 2.87). The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians. Subgroup analyses suggested that the "T" allele of the NOS3 +894G>T variant increases the risk of migraine among non-Caucasians (co-dominant model: pooled OR = 2.10; 95% CI 1.14 - 3.88).

Conclusions: Our findings appear to support the hypothesis that the TNF -308G>A polymorphism may act as a genetic susceptibility factor for migraine among non-Caucasians and that the NOS3 +894G>T polymorphism may modulate the risk of migraine among non-Caucasians.

No MeSH data available.


Related in: MedlinePlus