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Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.

Chen M, Tang W, Hou L, Liu R, Dong Z, Han X, Zhang X, Wan D, Yu S - PLoS ONE (2015)

Bottom Line: We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis.The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China; Department of Neurology, the First People's Hospital of Nanyang, Nanyang, Henan Province, China.

ABSTRACT

Background and objective: Conflicting data have been reported on the association between tumor necrosis factor (TNF) -308G>A and nitric oxide synthase 3 (NOS3) +894G>T polymorphisms and migraine. We performed a meta-analysis of case-control studies to evaluate whether the TNF -308G>A and NOS3 +894G>T polymorphisms confer genetic susceptibility to migraine.

Method: We performed an updated meta-analysis for TNF -308G>A and a meta-analysis for NOS3 +894G>T based on studies published up to July 2014. We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.

Results: Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis. Neither indicated overall associations between gene polymorphisms and migraine risk. Subgroup analyses suggested that the "A" allele of the TNF -308G>A variant increases the risk of migraine among non-Caucasians (dominant model: pooled OR = 1.82; 95% CI 1.15 - 2.87). The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians. Subgroup analyses suggested that the "T" allele of the NOS3 +894G>T variant increases the risk of migraine among non-Caucasians (co-dominant model: pooled OR = 2.10; 95% CI 1.14 - 3.88).

Conclusions: Our findings appear to support the hypothesis that the TNF -308G>A polymorphism may act as a genetic susceptibility factor for migraine among non-Caucasians and that the NOS3 +894G>T polymorphism may modulate the risk of migraine among non-Caucasians.

No MeSH data available.


Related in: MedlinePlus

Forest plot of migraine risk associated with the NOS3 +894G>T polymorphism stratified by ethnicity under the TT vs. GG model.The boxes and horizontal lines represent the OR and the corresponding 95% CI. The areas of the boxes indicate the weight (inverse of the variance). The diamonds correspond to the summary OR and 95% CI.
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pone.0129372.g004: Forest plot of migraine risk associated with the NOS3 +894G>T polymorphism stratified by ethnicity under the TT vs. GG model.The boxes and horizontal lines represent the OR and the corresponding 95% CI. The areas of the boxes indicate the weight (inverse of the variance). The diamonds correspond to the summary OR and 95% CI.

Mentions: By pooling the six selected studies with 1055 genotyped migraine cases and 877 controls for NOS3 +894G>T, no significant association between NOS3 +894G>T polymorphism and migraine risk was observed under any of the genetic models examined. Subgroup analyses suggested that the T allele of the NOS3 +894G>T variant increased the risk for migraine among non-Caucasians, which was driven by associations for MA (co-dominant model TT vs. GG: pooled OR = 2.10; 95% CI 1.14–3.88), as shown in Table 3 and Fig 4).


Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.

Chen M, Tang W, Hou L, Liu R, Dong Z, Han X, Zhang X, Wan D, Yu S - PLoS ONE (2015)

Forest plot of migraine risk associated with the NOS3 +894G>T polymorphism stratified by ethnicity under the TT vs. GG model.The boxes and horizontal lines represent the OR and the corresponding 95% CI. The areas of the boxes indicate the weight (inverse of the variance). The diamonds correspond to the summary OR and 95% CI.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476787&req=5

pone.0129372.g004: Forest plot of migraine risk associated with the NOS3 +894G>T polymorphism stratified by ethnicity under the TT vs. GG model.The boxes and horizontal lines represent the OR and the corresponding 95% CI. The areas of the boxes indicate the weight (inverse of the variance). The diamonds correspond to the summary OR and 95% CI.
Mentions: By pooling the six selected studies with 1055 genotyped migraine cases and 877 controls for NOS3 +894G>T, no significant association between NOS3 +894G>T polymorphism and migraine risk was observed under any of the genetic models examined. Subgroup analyses suggested that the T allele of the NOS3 +894G>T variant increased the risk for migraine among non-Caucasians, which was driven by associations for MA (co-dominant model TT vs. GG: pooled OR = 2.10; 95% CI 1.14–3.88), as shown in Table 3 and Fig 4).

Bottom Line: We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis.The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China; Department of Neurology, the First People's Hospital of Nanyang, Nanyang, Henan Province, China.

ABSTRACT

Background and objective: Conflicting data have been reported on the association between tumor necrosis factor (TNF) -308G>A and nitric oxide synthase 3 (NOS3) +894G>T polymorphisms and migraine. We performed a meta-analysis of case-control studies to evaluate whether the TNF -308G>A and NOS3 +894G>T polymorphisms confer genetic susceptibility to migraine.

Method: We performed an updated meta-analysis for TNF -308G>A and a meta-analysis for NOS3 +894G>T based on studies published up to July 2014. We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.

Results: Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis. Neither indicated overall associations between gene polymorphisms and migraine risk. Subgroup analyses suggested that the "A" allele of the TNF -308G>A variant increases the risk of migraine among non-Caucasians (dominant model: pooled OR = 1.82; 95% CI 1.15 - 2.87). The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians. Subgroup analyses suggested that the "T" allele of the NOS3 +894G>T variant increases the risk of migraine among non-Caucasians (co-dominant model: pooled OR = 2.10; 95% CI 1.14 - 3.88).

Conclusions: Our findings appear to support the hypothesis that the TNF -308G>A polymorphism may act as a genetic susceptibility factor for migraine among non-Caucasians and that the NOS3 +894G>T polymorphism may modulate the risk of migraine among non-Caucasians.

No MeSH data available.


Related in: MedlinePlus