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Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.

Chen M, Tang W, Hou L, Liu R, Dong Z, Han X, Zhang X, Wan D, Yu S - PLoS ONE (2015)

Bottom Line: We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis.The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China; Department of Neurology, the First People's Hospital of Nanyang, Nanyang, Henan Province, China.

ABSTRACT

Background and objective: Conflicting data have been reported on the association between tumor necrosis factor (TNF) -308G>A and nitric oxide synthase 3 (NOS3) +894G>T polymorphisms and migraine. We performed a meta-analysis of case-control studies to evaluate whether the TNF -308G>A and NOS3 +894G>T polymorphisms confer genetic susceptibility to migraine.

Method: We performed an updated meta-analysis for TNF -308G>A and a meta-analysis for NOS3 +894G>T based on studies published up to July 2014. We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.

Results: Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis. Neither indicated overall associations between gene polymorphisms and migraine risk. Subgroup analyses suggested that the "A" allele of the TNF -308G>A variant increases the risk of migraine among non-Caucasians (dominant model: pooled OR = 1.82; 95% CI 1.15 - 2.87). The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians. Subgroup analyses suggested that the "T" allele of the NOS3 +894G>T variant increases the risk of migraine among non-Caucasians (co-dominant model: pooled OR = 2.10; 95% CI 1.14 - 3.88).

Conclusions: Our findings appear to support the hypothesis that the TNF -308G>A polymorphism may act as a genetic susceptibility factor for migraine among non-Caucasians and that the NOS3 +894G>T polymorphism may modulate the risk of migraine among non-Caucasians.

No MeSH data available.


Related in: MedlinePlus

Forest plot of migraine with aura risk associated with the TNF –308G>A polymorphism stratified by ethnicity under the AA+GA vs. GG model.The boxes and horizontal lines represent the OR and the corresponding 95% CI. The areas of the boxes indicate the weight (inverse of the variance). The diamonds correspond to the summary OR and 95% CI.
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pone.0129372.g003: Forest plot of migraine with aura risk associated with the TNF –308G>A polymorphism stratified by ethnicity under the AA+GA vs. GG model.The boxes and horizontal lines represent the OR and the corresponding 95% CI. The areas of the boxes indicate the weight (inverse of the variance). The diamonds correspond to the summary OR and 95% CI.

Mentions: Table 2 lists the main meta-analysis results, which were calculated with the fixed-effects model when Ph > 0.10 and the random-effects model when the Ph < 0.10. Based on data from 11 studies for TNF –308G>A with 6682 genotyped migraine cases and 22591 controls, no significant association between TNF –308G>A polymorphism and migraine risk was observed under any of the genetic models. Strikingly, the meta-analysis provided an OR of 1.74 (95% CI: 1.13–2.67, Ph = 0.012) under A vs. G, an OR of 1.82 (95%CI: 1.15–2.87, Ph = 0.000) under AA+GA vs. GG, and an OR of 1.78 (95% CI: 1.17–2.72, Ph = 0.000) under GA vs. GG among non-Caucasians, while none of the contrast models showed a significant association in Caucasian populations (Fig 2). When stratifying the data by type of migraine, we observed an increased risk of migraine with aura (MA) among all participants (AA+GA vs. GG: pooled OR = 1.17, 95% CI: 1.05–1.30 Ph = 0.195; GA vs. GG: pooled OR = 1.17, 95% CI: 1.05–1.31, Ph = 0.123), especially in non-Caucasians (Table 2 and Fig 3). The association was stronger among females than males.


Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.

Chen M, Tang W, Hou L, Liu R, Dong Z, Han X, Zhang X, Wan D, Yu S - PLoS ONE (2015)

Forest plot of migraine with aura risk associated with the TNF –308G>A polymorphism stratified by ethnicity under the AA+GA vs. GG model.The boxes and horizontal lines represent the OR and the corresponding 95% CI. The areas of the boxes indicate the weight (inverse of the variance). The diamonds correspond to the summary OR and 95% CI.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476787&req=5

pone.0129372.g003: Forest plot of migraine with aura risk associated with the TNF –308G>A polymorphism stratified by ethnicity under the AA+GA vs. GG model.The boxes and horizontal lines represent the OR and the corresponding 95% CI. The areas of the boxes indicate the weight (inverse of the variance). The diamonds correspond to the summary OR and 95% CI.
Mentions: Table 2 lists the main meta-analysis results, which were calculated with the fixed-effects model when Ph > 0.10 and the random-effects model when the Ph < 0.10. Based on data from 11 studies for TNF –308G>A with 6682 genotyped migraine cases and 22591 controls, no significant association between TNF –308G>A polymorphism and migraine risk was observed under any of the genetic models. Strikingly, the meta-analysis provided an OR of 1.74 (95% CI: 1.13–2.67, Ph = 0.012) under A vs. G, an OR of 1.82 (95%CI: 1.15–2.87, Ph = 0.000) under AA+GA vs. GG, and an OR of 1.78 (95% CI: 1.17–2.72, Ph = 0.000) under GA vs. GG among non-Caucasians, while none of the contrast models showed a significant association in Caucasian populations (Fig 2). When stratifying the data by type of migraine, we observed an increased risk of migraine with aura (MA) among all participants (AA+GA vs. GG: pooled OR = 1.17, 95% CI: 1.05–1.30 Ph = 0.195; GA vs. GG: pooled OR = 1.17, 95% CI: 1.05–1.31, Ph = 0.123), especially in non-Caucasians (Table 2 and Fig 3). The association was stronger among females than males.

Bottom Line: We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis.The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China; Department of Neurology, the First People's Hospital of Nanyang, Nanyang, Henan Province, China.

ABSTRACT

Background and objective: Conflicting data have been reported on the association between tumor necrosis factor (TNF) -308G>A and nitric oxide synthase 3 (NOS3) +894G>T polymorphisms and migraine. We performed a meta-analysis of case-control studies to evaluate whether the TNF -308G>A and NOS3 +894G>T polymorphisms confer genetic susceptibility to migraine.

Method: We performed an updated meta-analysis for TNF -308G>A and a meta-analysis for NOS3 +894G>T based on studies published up to July 2014. We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.

Results: Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis. Neither indicated overall associations between gene polymorphisms and migraine risk. Subgroup analyses suggested that the "A" allele of the TNF -308G>A variant increases the risk of migraine among non-Caucasians (dominant model: pooled OR = 1.82; 95% CI 1.15 - 2.87). The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians. Subgroup analyses suggested that the "T" allele of the NOS3 +894G>T variant increases the risk of migraine among non-Caucasians (co-dominant model: pooled OR = 2.10; 95% CI 1.14 - 3.88).

Conclusions: Our findings appear to support the hypothesis that the TNF -308G>A polymorphism may act as a genetic susceptibility factor for migraine among non-Caucasians and that the NOS3 +894G>T polymorphism may modulate the risk of migraine among non-Caucasians.

No MeSH data available.


Related in: MedlinePlus