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Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.

Chen M, Tang W, Hou L, Liu R, Dong Z, Han X, Zhang X, Wan D, Yu S - PLoS ONE (2015)

Bottom Line: We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis.The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China; Department of Neurology, the First People's Hospital of Nanyang, Nanyang, Henan Province, China.

ABSTRACT

Background and objective: Conflicting data have been reported on the association between tumor necrosis factor (TNF) -308G>A and nitric oxide synthase 3 (NOS3) +894G>T polymorphisms and migraine. We performed a meta-analysis of case-control studies to evaluate whether the TNF -308G>A and NOS3 +894G>T polymorphisms confer genetic susceptibility to migraine.

Method: We performed an updated meta-analysis for TNF -308G>A and a meta-analysis for NOS3 +894G>T based on studies published up to July 2014. We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.

Results: Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis. Neither indicated overall associations between gene polymorphisms and migraine risk. Subgroup analyses suggested that the "A" allele of the TNF -308G>A variant increases the risk of migraine among non-Caucasians (dominant model: pooled OR = 1.82; 95% CI 1.15 - 2.87). The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians. Subgroup analyses suggested that the "T" allele of the NOS3 +894G>T variant increases the risk of migraine among non-Caucasians (co-dominant model: pooled OR = 2.10; 95% CI 1.14 - 3.88).

Conclusions: Our findings appear to support the hypothesis that the TNF -308G>A polymorphism may act as a genetic susceptibility factor for migraine among non-Caucasians and that the NOS3 +894G>T polymorphism may modulate the risk of migraine among non-Caucasians.

No MeSH data available.


Related in: MedlinePlus

Flow chart of the study selection process.
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pone.0129372.g001: Flow chart of the study selection process.

Mentions: Two of the authors (MC and WT) searched the PubMed, EMBASE, Science Citation Index (SCI), and Cochrane Library electronic databases for tumor necrosis factor and endothelial nitric oxide synthase (“tumor necrosis factor-α” OR ‘‘tumor necrosis factor-alpha” OR “TNF-α” OR “TNF-alpha” OR “endothelial nitric oxide synthase” OR “eNOS”) AND “headache” OR “headache disorder” OR “migraine” OR “migraine disorder” OR “migraine with aura” OR “migraine without aura” AND “gene” OR “polymorphism” OR “genetic variation” OR “polymorphisms” OR “rs1800629” OR TNF –308G>A” OR “rs1799983” OR “Glu298Asp” OR “NOS3 +894G/T.” The search was performed without any restrictions, except that the studies were conducted in humans. The full electronic search strategy of TNF –308G>A for PubMed was (“migraine disorders” [MeSH Terms] OR “migraine disorders” [All Fields] OR “migraine” [All Fields] OR “migraine disorder” [All Fields] OR “headache disorders” [MeSH Terms] OR “headache disorders” [All Fields] OR “headache” [All Fields] OR “headache disorder” [All Fields])) OR “migraine with aura” [MeSH Terms] OR “migraine with aura” [All Fields] OR “migraine without aura” [MeSH Terms] OR “migraine without aura” [All Fields]) AND (“tumor necrosis factor-alpha” [MeSH Terms] OR “tumor necrosis factor-alpha” [All Fields] OR “tumor necrosis factor alpha” [All Fields] OR “tumor necrosis factors” [MeSH Terms] OR “tumor necrosis factors” [All Fields] OR “tnf” [All Fields] OR “tnf alpha” [All Fields]) AND (“genetic” [All Fields] OR “genetics” [All Fields] OR “genetics” [MeSH Terms] OR “polymorphism,” “genetic” [MeSH Terms] OR “genetic polymorphism” [All Fields] OR (“polymorphism” [All Fields] AND “genetic” [All Fields]) OR “variant” [All Fields] OR “variants” [All Fields] OR “rs1800629” OR “TNF –308G>A”) AND “humans” [MeSH Terms]. In addition, the reference lists of selected papers and potentially relevant studies in the previous meta-analyses were also screened to further identify potentially relevant papers through reference association. The last search was updated in July 2014. The selection process is shown as a flow chart in Fig 1.


Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.

Chen M, Tang W, Hou L, Liu R, Dong Z, Han X, Zhang X, Wan D, Yu S - PLoS ONE (2015)

Flow chart of the study selection process.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476787&req=5

pone.0129372.g001: Flow chart of the study selection process.
Mentions: Two of the authors (MC and WT) searched the PubMed, EMBASE, Science Citation Index (SCI), and Cochrane Library electronic databases for tumor necrosis factor and endothelial nitric oxide synthase (“tumor necrosis factor-α” OR ‘‘tumor necrosis factor-alpha” OR “TNF-α” OR “TNF-alpha” OR “endothelial nitric oxide synthase” OR “eNOS”) AND “headache” OR “headache disorder” OR “migraine” OR “migraine disorder” OR “migraine with aura” OR “migraine without aura” AND “gene” OR “polymorphism” OR “genetic variation” OR “polymorphisms” OR “rs1800629” OR TNF –308G>A” OR “rs1799983” OR “Glu298Asp” OR “NOS3 +894G/T.” The search was performed without any restrictions, except that the studies were conducted in humans. The full electronic search strategy of TNF –308G>A for PubMed was (“migraine disorders” [MeSH Terms] OR “migraine disorders” [All Fields] OR “migraine” [All Fields] OR “migraine disorder” [All Fields] OR “headache disorders” [MeSH Terms] OR “headache disorders” [All Fields] OR “headache” [All Fields] OR “headache disorder” [All Fields])) OR “migraine with aura” [MeSH Terms] OR “migraine with aura” [All Fields] OR “migraine without aura” [MeSH Terms] OR “migraine without aura” [All Fields]) AND (“tumor necrosis factor-alpha” [MeSH Terms] OR “tumor necrosis factor-alpha” [All Fields] OR “tumor necrosis factor alpha” [All Fields] OR “tumor necrosis factors” [MeSH Terms] OR “tumor necrosis factors” [All Fields] OR “tnf” [All Fields] OR “tnf alpha” [All Fields]) AND (“genetic” [All Fields] OR “genetics” [All Fields] OR “genetics” [MeSH Terms] OR “polymorphism,” “genetic” [MeSH Terms] OR “genetic polymorphism” [All Fields] OR (“polymorphism” [All Fields] AND “genetic” [All Fields]) OR “variant” [All Fields] OR “variants” [All Fields] OR “rs1800629” OR “TNF –308G>A”) AND “humans” [MeSH Terms]. In addition, the reference lists of selected papers and potentially relevant studies in the previous meta-analyses were also screened to further identify potentially relevant papers through reference association. The last search was updated in July 2014. The selection process is shown as a flow chart in Fig 1.

Bottom Line: We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis.The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China; Department of Neurology, the First People's Hospital of Nanyang, Nanyang, Henan Province, China.

ABSTRACT

Background and objective: Conflicting data have been reported on the association between tumor necrosis factor (TNF) -308G>A and nitric oxide synthase 3 (NOS3) +894G>T polymorphisms and migraine. We performed a meta-analysis of case-control studies to evaluate whether the TNF -308G>A and NOS3 +894G>T polymorphisms confer genetic susceptibility to migraine.

Method: We performed an updated meta-analysis for TNF -308G>A and a meta-analysis for NOS3 +894G>T based on studies published up to July 2014. We calculated study specific odds ratios (OR) and 95% confidence intervals (95% CI) assuming allele contrast, dominant model, recessive model, and co-dominant model as pooled effect estimates.

Results: Eleven studies in 6682 migraineurs and 22591 controls for TNF -308G>A and six studies in 1055 migraineurs and 877 controls for NOS3 +894G>T were included in the analysis. Neither indicated overall associations between gene polymorphisms and migraine risk. Subgroup analyses suggested that the "A" allele of the TNF -308G>A variant increases the risk of migraine among non-Caucasians (dominant model: pooled OR = 1.82; 95% CI 1.15 - 2.87). The risk of migraine with aura (MA) was increased among both Caucasians and non-Caucasians. Subgroup analyses suggested that the "T" allele of the NOS3 +894G>T variant increases the risk of migraine among non-Caucasians (co-dominant model: pooled OR = 2.10; 95% CI 1.14 - 3.88).

Conclusions: Our findings appear to support the hypothesis that the TNF -308G>A polymorphism may act as a genetic susceptibility factor for migraine among non-Caucasians and that the NOS3 +894G>T polymorphism may modulate the risk of migraine among non-Caucasians.

No MeSH data available.


Related in: MedlinePlus