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Alcohol-Preferring Rats Show Goal Oriented Behaviour to Food Incentives but Are Neither Sign-Trackers Nor Impulsive.

Peña-Oliver Y, Giuliano C, Economidou D, Goodlett CR, Robbins TW, Dalley JW, Everitt BJ - PLoS ONE (2015)

Bottom Line: Drug addiction is often associated with impulsivity and altered behavioural responses to both primary and conditioned rewards.These findings indicate that high alcohol preferring and drinking P rats are neither intrinsically impulsive nor do they exhibit impulsivity after exposure to alcohol.However, P rats do show increased goal-directed behaviour to food incentives and this may be associated with their strong preference for alcohol.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge, United Kingdom.

ABSTRACT
Drug addiction is often associated with impulsivity and altered behavioural responses to both primary and conditioned rewards. Here we investigated whether selectively bred alcohol-preferring (P) and alcohol-nonpreferring (NP) rats show differential levels of impulsivity and conditioned behavioural responses to food incentives. P and NP rats were assessed for impulsivity in the 5-choice serial reaction time task (5-CSRTT), a widely used translational task in humans and other animals, as well as Pavlovian conditioned approach to measure sign- and goal-tracking behaviour. Drug-naïve P and NP rats showed similar levels of impulsivity on the 5-CSRTT, assessed by the number of premature, anticipatory responses, even when the waiting interval to respond was increased. However, unlike NP rats, P rats were faster to enter the food magazine and spent more time in this area. In addition, P rats showed higher levels of goal-tracking responses than NP rats, as measured by the number of magazine nose-pokes during the presentation of a food conditioned stimulus. By contrast, NP showed higher levels of sign-tracking behaviour than P rats. Following a 4-week exposure to intermittent alcohol we confirmed that P rats had a marked preference for, and consumed more alcohol than, NP rats, but were not more impulsive when re-tested in the 5-CSRTT. These findings indicate that high alcohol preferring and drinking P rats are neither intrinsically impulsive nor do they exhibit impulsivity after exposure to alcohol. However, P rats do show increased goal-directed behaviour to food incentives and this may be associated with their strong preference for alcohol.

No MeSH data available.


Related in: MedlinePlus

Intermittent access two-bottle choice procedure.Data represent the mean ± SE of alcohol preference (a) and alcohol intake (g/kg/day) (b) during the 12 sessions of intermittent access to alcohol in alcohol-preferring rats (P, closed squares) and alcohol-non-preferring rats (NP, open circles). All p<0.05 (adjusted after Bonferroni correction): (*) significant group differences, (•) vs session 1.
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pone.0131016.g003: Intermittent access two-bottle choice procedure.Data represent the mean ± SE of alcohol preference (a) and alcohol intake (g/kg/day) (b) during the 12 sessions of intermittent access to alcohol in alcohol-preferring rats (P, closed squares) and alcohol-non-preferring rats (NP, open circles). All p<0.05 (adjusted after Bonferroni correction): (*) significant group differences, (•) vs session 1.

Mentions: Fig 3 shows the total alcohol intake and preference for P and NP rats during the 12 sessions of intermittent access to alcohol and water in the home cage. P rats consumed significantly more alcohol than NP rats (group x session interaction: F11,286 = 36.78, p<0.001, ε = 0.32; group: F1,26 = 143.63, p<0.001, Fig 3A) and showed a significantly higher preference for alcohol (group x session interaction: F11,286 = 31.76, p<0.001, ε = 0.33, group: F1,26 = 189.94, p<0.001, Fig 3B). P rats consumed approximately 5 g alcohol/kg/day during the final 5 sessions whereas NP rats consumed less than 1g alcohol/kg/day over a similar period.


Alcohol-Preferring Rats Show Goal Oriented Behaviour to Food Incentives but Are Neither Sign-Trackers Nor Impulsive.

Peña-Oliver Y, Giuliano C, Economidou D, Goodlett CR, Robbins TW, Dalley JW, Everitt BJ - PLoS ONE (2015)

Intermittent access two-bottle choice procedure.Data represent the mean ± SE of alcohol preference (a) and alcohol intake (g/kg/day) (b) during the 12 sessions of intermittent access to alcohol in alcohol-preferring rats (P, closed squares) and alcohol-non-preferring rats (NP, open circles). All p<0.05 (adjusted after Bonferroni correction): (*) significant group differences, (•) vs session 1.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476783&req=5

pone.0131016.g003: Intermittent access two-bottle choice procedure.Data represent the mean ± SE of alcohol preference (a) and alcohol intake (g/kg/day) (b) during the 12 sessions of intermittent access to alcohol in alcohol-preferring rats (P, closed squares) and alcohol-non-preferring rats (NP, open circles). All p<0.05 (adjusted after Bonferroni correction): (*) significant group differences, (•) vs session 1.
Mentions: Fig 3 shows the total alcohol intake and preference for P and NP rats during the 12 sessions of intermittent access to alcohol and water in the home cage. P rats consumed significantly more alcohol than NP rats (group x session interaction: F11,286 = 36.78, p<0.001, ε = 0.32; group: F1,26 = 143.63, p<0.001, Fig 3A) and showed a significantly higher preference for alcohol (group x session interaction: F11,286 = 31.76, p<0.001, ε = 0.33, group: F1,26 = 189.94, p<0.001, Fig 3B). P rats consumed approximately 5 g alcohol/kg/day during the final 5 sessions whereas NP rats consumed less than 1g alcohol/kg/day over a similar period.

Bottom Line: Drug addiction is often associated with impulsivity and altered behavioural responses to both primary and conditioned rewards.These findings indicate that high alcohol preferring and drinking P rats are neither intrinsically impulsive nor do they exhibit impulsivity after exposure to alcohol.However, P rats do show increased goal-directed behaviour to food incentives and this may be associated with their strong preference for alcohol.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge, United Kingdom.

ABSTRACT
Drug addiction is often associated with impulsivity and altered behavioural responses to both primary and conditioned rewards. Here we investigated whether selectively bred alcohol-preferring (P) and alcohol-nonpreferring (NP) rats show differential levels of impulsivity and conditioned behavioural responses to food incentives. P and NP rats were assessed for impulsivity in the 5-choice serial reaction time task (5-CSRTT), a widely used translational task in humans and other animals, as well as Pavlovian conditioned approach to measure sign- and goal-tracking behaviour. Drug-naïve P and NP rats showed similar levels of impulsivity on the 5-CSRTT, assessed by the number of premature, anticipatory responses, even when the waiting interval to respond was increased. However, unlike NP rats, P rats were faster to enter the food magazine and spent more time in this area. In addition, P rats showed higher levels of goal-tracking responses than NP rats, as measured by the number of magazine nose-pokes during the presentation of a food conditioned stimulus. By contrast, NP showed higher levels of sign-tracking behaviour than P rats. Following a 4-week exposure to intermittent alcohol we confirmed that P rats had a marked preference for, and consumed more alcohol than, NP rats, but were not more impulsive when re-tested in the 5-CSRTT. These findings indicate that high alcohol preferring and drinking P rats are neither intrinsically impulsive nor do they exhibit impulsivity after exposure to alcohol. However, P rats do show increased goal-directed behaviour to food incentives and this may be associated with their strong preference for alcohol.

No MeSH data available.


Related in: MedlinePlus