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Myocardial recovery during mechanical circulatory support: cellular, molecular, genomic and organ levels.

Dandel M, Hetzer R - Heart Lung Vessel (2015)

Bottom Line: Mechanical circulatory support is a life-saving therapy that will become either a bridge-to-transplantation or definitive therapy if heart transplantation is not possible.Failing hearts supported by a ventricular assist device  were often found to recover at molecular and cellular level but translation of these changes into functionally-stable cardiac recovery allowing long-term heart transplantation/ventricular assist device-free outcomes after weaning from ventricular assist device is relatively rare and related to the etiology, severity and duration of myocardial damage.The reason for the discrepancy between high recovery rates on the cellular and molecular levels and the low rate of cardiac recovery allowing ventricular assist device explantation is unknown.

View Article: PubMed Central - PubMed

Affiliation: Deutsches Herzzentrum Berlin, Germany, Department of Cardiothoracic and Vascular Surgery.

ABSTRACT
Mechanical circulatory support is a life-saving therapy that will become either a bridge-to-transplantation or definitive therapy if heart transplantation is not possible. Failing hearts supported by a ventricular assist deviceĀ  were often found to recover at molecular and cellular level but translation of these changes into functionally-stable cardiac recovery allowing long-term heart transplantation/ventricular assist device-free outcomes after weaning from ventricular assist device is relatively rare and related to the etiology, severity and duration of myocardial damage. The reason for the discrepancy between high recovery rates on the cellular and molecular levels and the low rate of cardiac recovery allowing ventricular assist device explantation is unknown.

No MeSH data available.


Related in: MedlinePlus

Myocardial recovery during MCS. MCS = mechanical circulatory support.
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Figure 001: Myocardial recovery during MCS. MCS = mechanical circulatory support.


Myocardial recovery during mechanical circulatory support: cellular, molecular, genomic and organ levels.

Dandel M, Hetzer R - Heart Lung Vessel (2015)

Myocardial recovery during MCS. MCS = mechanical circulatory support.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476765&req=5

Figure 001: Myocardial recovery during MCS. MCS = mechanical circulatory support.
Bottom Line: Mechanical circulatory support is a life-saving therapy that will become either a bridge-to-transplantation or definitive therapy if heart transplantation is not possible.Failing hearts supported by a ventricular assist device  were often found to recover at molecular and cellular level but translation of these changes into functionally-stable cardiac recovery allowing long-term heart transplantation/ventricular assist device-free outcomes after weaning from ventricular assist device is relatively rare and related to the etiology, severity and duration of myocardial damage.The reason for the discrepancy between high recovery rates on the cellular and molecular levels and the low rate of cardiac recovery allowing ventricular assist device explantation is unknown.

View Article: PubMed Central - PubMed

Affiliation: Deutsches Herzzentrum Berlin, Germany, Department of Cardiothoracic and Vascular Surgery.

ABSTRACT
Mechanical circulatory support is a life-saving therapy that will become either a bridge-to-transplantation or definitive therapy if heart transplantation is not possible. Failing hearts supported by a ventricular assist deviceĀ  were often found to recover at molecular and cellular level but translation of these changes into functionally-stable cardiac recovery allowing long-term heart transplantation/ventricular assist device-free outcomes after weaning from ventricular assist device is relatively rare and related to the etiology, severity and duration of myocardial damage. The reason for the discrepancy between high recovery rates on the cellular and molecular levels and the low rate of cardiac recovery allowing ventricular assist device explantation is unknown.

No MeSH data available.


Related in: MedlinePlus