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Vitamin B12 and Folic Acid Improve Gross Motor and Problem-Solving Skills in Young North Indian Children: A Randomized Placebo-Controlled Trial.

Kvestad I, Taneja S, Kumar T, Hysing M, Refsum H, Yajnik CS, Bhandari N, Strand TA, Folate and Vitamin B12 Study Gro - PLoS ONE (2015)

Bottom Line: The objective of this study was to measure the effect of daily supplementation of vitamin B12 and/or folic acid on development in young North Indian children.The effect was highest in susceptible subgroups consisting of stunted children, those with high plasma homocysteine (> 10 μmol/L) or in those who were younger than 24 at end study.Our findings suggest that supplementation of vitamin B12 and folic acid benefit development in North Indian Children.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological and Medical Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway; Regional Centre for Child and Youth Mental Health and Child Welfare, West, Uni Research Health, Bergen, Norway.

ABSTRACT

Objectives: Deficiencies of vitamin B12 and folate are associated with delayed development and neurological manifestations. The objective of this study was to measure the effect of daily supplementation of vitamin B12 and/or folic acid on development in young North Indian children.

Methods: In a randomized, double blind trial, children aged six to 30 months, received supplement with placebo or vitamin B12 and/or folic acid for six months. Children were allocated in a 1:1:1:1 ratio in a factorial design and in blocks of 16. We measured development in 422 children by the Ages and Stages Questionnaire 3rd ed. at the end of the intervention.

Results: Compared to placebo, children who received both vitamin B12 and folic acid had 0.45 (95% CI 0.19, 0.73) and 0.28 (95% CI 0.02, 0.54) higher SD-units in the domains of gross motor and problem solving functioning, respectively. The effect was highest in susceptible subgroups consisting of stunted children, those with high plasma homocysteine (> 10 μmol/L) or in those who were younger than 24 at end study. With the exception of a significant improvement on gross motor scores by vitamin B12 alone, supplementation of either vitamin alone had no effect on any of the outcomes.

Conclusion: Our findings suggest that supplementation of vitamin B12 and folic acid benefit development in North Indian Children.

Trial registration: ClinicalTrials.gov NCT00717730.

No MeSH data available.


Related in: MedlinePlus

Trial profile of a randomized, placebo controlled trial on the effect of vitamin B12 and/or folic acid administration on development in 6–30 months old North Indian children.
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pone.0129915.g001: Trial profile of a randomized, placebo controlled trial on the effect of vitamin B12 and/or folic acid administration on development in 6–30 months old North Indian children.

Mentions: Fig 1 shows the flow of the participants through the study. Among the 1000 children randomized into the main study, the last 440 enrollments were included for developmental assessment. Three children were not available for assessment and 15 did not wish to participate, hence the final number of participants was 422. Baseline characteristics for the children in the four intervention groups are presented in Table 1. As reported from the main study, adherence was excellent and 96% of the scheduled doses were ingested [15]. Furthermore, compared to the placebo group, plasma vitamin B12 concentrations increased substantially in the group of children that received vitamin B12 alone or in combination with folic acid. Likewise, plasma folate levels increased significantly in children who received folic acid alone or in combination with vitamin B12 (Table 2).


Vitamin B12 and Folic Acid Improve Gross Motor and Problem-Solving Skills in Young North Indian Children: A Randomized Placebo-Controlled Trial.

Kvestad I, Taneja S, Kumar T, Hysing M, Refsum H, Yajnik CS, Bhandari N, Strand TA, Folate and Vitamin B12 Study Gro - PLoS ONE (2015)

Trial profile of a randomized, placebo controlled trial on the effect of vitamin B12 and/or folic acid administration on development in 6–30 months old North Indian children.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476750&req=5

pone.0129915.g001: Trial profile of a randomized, placebo controlled trial on the effect of vitamin B12 and/or folic acid administration on development in 6–30 months old North Indian children.
Mentions: Fig 1 shows the flow of the participants through the study. Among the 1000 children randomized into the main study, the last 440 enrollments were included for developmental assessment. Three children were not available for assessment and 15 did not wish to participate, hence the final number of participants was 422. Baseline characteristics for the children in the four intervention groups are presented in Table 1. As reported from the main study, adherence was excellent and 96% of the scheduled doses were ingested [15]. Furthermore, compared to the placebo group, plasma vitamin B12 concentrations increased substantially in the group of children that received vitamin B12 alone or in combination with folic acid. Likewise, plasma folate levels increased significantly in children who received folic acid alone or in combination with vitamin B12 (Table 2).

Bottom Line: The objective of this study was to measure the effect of daily supplementation of vitamin B12 and/or folic acid on development in young North Indian children.The effect was highest in susceptible subgroups consisting of stunted children, those with high plasma homocysteine (> 10 μmol/L) or in those who were younger than 24 at end study.Our findings suggest that supplementation of vitamin B12 and folic acid benefit development in North Indian Children.

View Article: PubMed Central - PubMed

Affiliation: Department of Biological and Medical Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway; Regional Centre for Child and Youth Mental Health and Child Welfare, West, Uni Research Health, Bergen, Norway.

ABSTRACT

Objectives: Deficiencies of vitamin B12 and folate are associated with delayed development and neurological manifestations. The objective of this study was to measure the effect of daily supplementation of vitamin B12 and/or folic acid on development in young North Indian children.

Methods: In a randomized, double blind trial, children aged six to 30 months, received supplement with placebo or vitamin B12 and/or folic acid for six months. Children were allocated in a 1:1:1:1 ratio in a factorial design and in blocks of 16. We measured development in 422 children by the Ages and Stages Questionnaire 3rd ed. at the end of the intervention.

Results: Compared to placebo, children who received both vitamin B12 and folic acid had 0.45 (95% CI 0.19, 0.73) and 0.28 (95% CI 0.02, 0.54) higher SD-units in the domains of gross motor and problem solving functioning, respectively. The effect was highest in susceptible subgroups consisting of stunted children, those with high plasma homocysteine (> 10 μmol/L) or in those who were younger than 24 at end study. With the exception of a significant improvement on gross motor scores by vitamin B12 alone, supplementation of either vitamin alone had no effect on any of the outcomes.

Conclusion: Our findings suggest that supplementation of vitamin B12 and folic acid benefit development in North Indian Children.

Trial registration: ClinicalTrials.gov NCT00717730.

No MeSH data available.


Related in: MedlinePlus