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GDM Women's Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain on Offspring Overweight Status.

Leng J, Li W, Zhang S, Liu H, Wang L, Liu G, Li N, Redman LM, Baccarelli AA, Hou L, Hu G - PLoS ONE (2015)

Bottom Line: We performed a retrospective cohort study in 1263 GDM mother-child pairs.Maternal pre-pregnancy BMI and GWG were positively associated with birth weight for gestational age Z score and birth weight for length for gestational age Z score at birth, and weight for age Z score, length/height for age Z score, and weight for length/height Z score at of 1-5 years old offspring.Offspring born to GDM mothers with pre-pregnancy overweight/obesity or excessive GWG were associated with increased risks of large for gestational age and macrosomia at birth, and childhood overweight at 1-5 years old, compared with those born to GDM mothers with pre-pregnancy normal weight and adequate GWG.

View Article: PubMed Central - PubMed

Affiliation: Project Office, Tianjin Women's and Children's Health Center, Tianjin, China.

ABSTRACT

Objectives: To examine the association of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with anthropometry in the offspring of mothers with gestational diabetes mellitus (GDM).

Methods: We performed a retrospective cohort study in 1263 GDM mother-child pairs. General linear models and Logistic regression models were used to assess the single and joint associations of maternal pre-pregnancy BMI (normal weight, overweight, and obesity) and GWG (inadequate, adequate and excessive GWG) with anthropometry and overweight status in the offspring from birth to 1-5 years old.

Results: Maternal pre-pregnancy BMI and GWG were positively associated with birth weight for gestational age Z score and birth weight for length for gestational age Z score at birth, and weight for age Z score, length/height for age Z score, and weight for length/height Z score at of 1-5 years old offspring. Maternal pre-pregnancy overweight, obesity, and excessive GWG were associated with increased risks of large for gestational age [ORs 95% CIs = 1.87 (1.37-2.55), 2.98 (1.89-4.69), and 2.93 (2.07-4.13), respectively] and macrosomia [ORs 95% CIs = 2.06 (1.50-2.84), 2.89 (1.78-4.70), and 2.84 (1.98-4.06), respectively] at birth and childhood overweight at 1-5 years old [ORs 95% CIs = 1.26 (0.92-1.73), 1.96 (1.24-3.09), and 1.59 (1.15-2.21), respectively].

Conclusions: Offspring born to GDM mothers with pre-pregnancy overweight/obesity or excessive GWG were associated with increased risks of large for gestational age and macrosomia at birth, and childhood overweight at 1-5 years old, compared with those born to GDM mothers with pre-pregnancy normal weight and adequate GWG.

No MeSH data available.


Related in: MedlinePlus

Odds ratios (95% CIs) of large for gestational age and macrosomia at birth and overweight at 1–5 years old according to maternal pre-pregnancy body mass index and gestational weight gain categories.
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pone.0129536.g001: Odds ratios (95% CIs) of large for gestational age and macrosomia at birth and overweight at 1–5 years old according to maternal pre-pregnancy body mass index and gestational weight gain categories.

Mentions: Maternal pre-pregnancy BMI and GWG were positively associated with birth weight for gestational age Z score (S2 Table) and birth weight for length for gestational age Z score of neonates (Table 2). Compared to offspring born to mothers with pre-pregnancy normal weight or adequate GWG, offspring born to GDM mothers with pre-pregnancy overweight/obesity or excessive GWG had larger mean values of z scores for birth weight for gestational age and birth weight for length for gestational age (Model 1). Maternal pre-pregnancy overweight, obesity, and excessive GWG were associated with increased risks of large for gestational age [ORs 95% CIs = 1.87 (1.37–2.55), 2.98 (1.89–4.69), and 2.93 (2.07–4.13), respectively] and macrosomia [ORs 95% CIs = 2.06 (1.50–2.84), 2.89 (1.78–4.70), and 2.84 (1.98–4.06), respectively] at birth, compared with maternal pre-pregnancy normal weight and adequate GWG (Fig 1).


GDM Women's Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain on Offspring Overweight Status.

Leng J, Li W, Zhang S, Liu H, Wang L, Liu G, Li N, Redman LM, Baccarelli AA, Hou L, Hu G - PLoS ONE (2015)

Odds ratios (95% CIs) of large for gestational age and macrosomia at birth and overweight at 1–5 years old according to maternal pre-pregnancy body mass index and gestational weight gain categories.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476720&req=5

pone.0129536.g001: Odds ratios (95% CIs) of large for gestational age and macrosomia at birth and overweight at 1–5 years old according to maternal pre-pregnancy body mass index and gestational weight gain categories.
Mentions: Maternal pre-pregnancy BMI and GWG were positively associated with birth weight for gestational age Z score (S2 Table) and birth weight for length for gestational age Z score of neonates (Table 2). Compared to offspring born to mothers with pre-pregnancy normal weight or adequate GWG, offspring born to GDM mothers with pre-pregnancy overweight/obesity or excessive GWG had larger mean values of z scores for birth weight for gestational age and birth weight for length for gestational age (Model 1). Maternal pre-pregnancy overweight, obesity, and excessive GWG were associated with increased risks of large for gestational age [ORs 95% CIs = 1.87 (1.37–2.55), 2.98 (1.89–4.69), and 2.93 (2.07–4.13), respectively] and macrosomia [ORs 95% CIs = 2.06 (1.50–2.84), 2.89 (1.78–4.70), and 2.84 (1.98–4.06), respectively] at birth, compared with maternal pre-pregnancy normal weight and adequate GWG (Fig 1).

Bottom Line: We performed a retrospective cohort study in 1263 GDM mother-child pairs.Maternal pre-pregnancy BMI and GWG were positively associated with birth weight for gestational age Z score and birth weight for length for gestational age Z score at birth, and weight for age Z score, length/height for age Z score, and weight for length/height Z score at of 1-5 years old offspring.Offspring born to GDM mothers with pre-pregnancy overweight/obesity or excessive GWG were associated with increased risks of large for gestational age and macrosomia at birth, and childhood overweight at 1-5 years old, compared with those born to GDM mothers with pre-pregnancy normal weight and adequate GWG.

View Article: PubMed Central - PubMed

Affiliation: Project Office, Tianjin Women's and Children's Health Center, Tianjin, China.

ABSTRACT

Objectives: To examine the association of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with anthropometry in the offspring of mothers with gestational diabetes mellitus (GDM).

Methods: We performed a retrospective cohort study in 1263 GDM mother-child pairs. General linear models and Logistic regression models were used to assess the single and joint associations of maternal pre-pregnancy BMI (normal weight, overweight, and obesity) and GWG (inadequate, adequate and excessive GWG) with anthropometry and overweight status in the offspring from birth to 1-5 years old.

Results: Maternal pre-pregnancy BMI and GWG were positively associated with birth weight for gestational age Z score and birth weight for length for gestational age Z score at birth, and weight for age Z score, length/height for age Z score, and weight for length/height Z score at of 1-5 years old offspring. Maternal pre-pregnancy overweight, obesity, and excessive GWG were associated with increased risks of large for gestational age [ORs 95% CIs = 1.87 (1.37-2.55), 2.98 (1.89-4.69), and 2.93 (2.07-4.13), respectively] and macrosomia [ORs 95% CIs = 2.06 (1.50-2.84), 2.89 (1.78-4.70), and 2.84 (1.98-4.06), respectively] at birth and childhood overweight at 1-5 years old [ORs 95% CIs = 1.26 (0.92-1.73), 1.96 (1.24-3.09), and 1.59 (1.15-2.21), respectively].

Conclusions: Offspring born to GDM mothers with pre-pregnancy overweight/obesity or excessive GWG were associated with increased risks of large for gestational age and macrosomia at birth, and childhood overweight at 1-5 years old, compared with those born to GDM mothers with pre-pregnancy normal weight and adequate GWG.

No MeSH data available.


Related in: MedlinePlus