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Computer-Based Cognitive Programs for Improvement of Memory, Processing Speed and Executive Function during Age-Related Cognitive Decline: A Meta-Analysis.

Shao YK, Mang J, Li PL, Wang J, Deng T, Xu ZX - PLoS ONE (2015)

Bottom Line: The standardized mean difference (SMD) and 95% confidence intervals (CI) of a random-effects model were calculated.The aggregated results indicate that CCP improves memory performance (SMD, 0.31; 95% CI 0.16 to 0.45; p < 0.0001) and processing speed (SMD, 0.50; 95% CI 0.14 to 0.87; p = 0.007) but not executive function (SMD, -0.12; 95% CI -0.33 to 0.09; p = 0.27).However, more studies with longer follow-ups are warranted to confirm the current findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, China.

ABSTRACT

Background: Several studies have assessed the effects of computer-based cognitive programs (CCP) in the management of age-related cognitive decline, but the role of CCP remains controversial. Therefore, this systematic review evaluated the evidence on the efficacy of CCP for age-related cognitive decline in healthy older adults.

Methods: Six electronic databases (through October 2014) were searched. The risk of bias was assessed using the Cochrane Collaboration tool. The standardized mean difference (SMD) and 95% confidence intervals (CI) of a random-effects model were calculated. The heterogeneity was assessed using the Cochran Q statistic and quantified with the I2 index.

Results: Twelve studies were included in the current review and were considered as moderate to high methodological quality. The aggregated results indicate that CCP improves memory performance (SMD, 0.31; 95% CI 0.16 to 0.45; p < 0.0001) and processing speed (SMD, 0.50; 95% CI 0.14 to 0.87; p = 0.007) but not executive function (SMD, -0.12; 95% CI -0.33 to 0.09; p = 0.27). Furthermore, there were long-term gains in memory performance (SMD, 0.59; 95% CI 0.13 to 1.05; p = 0.01).

Conclusion: CCP may be a valid complementary and alternative therapy for age-related cognitive decline, especially for memory performance and processing speed. However, more studies with longer follow-ups are warranted to confirm the current findings.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the effect of computer-based cognitive programs in executive function.
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pone.0130831.g005: Forest plot of the effect of computer-based cognitive programs in executive function.

Mentions: Executive function consists of a broad spectrum of abilities, including cognitive flexibility, planning, and abstract thinking skills. Older adults usually have poorer executive function due to cognitive decline [32]. In total, 6 studies [14,15,17,23,24,26] assessed the effect of CCP on executive function. The aggregated results indicated that there was no significant difference between CCP and control interventions on executive function (SMD, -0.12; 95% CI -0.33 to 0.09; p = 0.27, Fig 5). In the subgroup meta-analyses, the results did not support the effect of CCP in the Stroop test (SMD, 0.12; 95% CI -0.08 to 0.33; p = 0.25, Fig 5) [14,15,23], trail marking test A (SMD, -0.03; 95% CI -0.34 to 0.28; p = 0.87, Fig 5) [15,24] or trail marking test B (SMD, -0.20; 95% CI -0.65 to 0.25; p = 0.38, Fig 5) [15,24,26].


Computer-Based Cognitive Programs for Improvement of Memory, Processing Speed and Executive Function during Age-Related Cognitive Decline: A Meta-Analysis.

Shao YK, Mang J, Li PL, Wang J, Deng T, Xu ZX - PLoS ONE (2015)

Forest plot of the effect of computer-based cognitive programs in executive function.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476706&req=5

pone.0130831.g005: Forest plot of the effect of computer-based cognitive programs in executive function.
Mentions: Executive function consists of a broad spectrum of abilities, including cognitive flexibility, planning, and abstract thinking skills. Older adults usually have poorer executive function due to cognitive decline [32]. In total, 6 studies [14,15,17,23,24,26] assessed the effect of CCP on executive function. The aggregated results indicated that there was no significant difference between CCP and control interventions on executive function (SMD, -0.12; 95% CI -0.33 to 0.09; p = 0.27, Fig 5). In the subgroup meta-analyses, the results did not support the effect of CCP in the Stroop test (SMD, 0.12; 95% CI -0.08 to 0.33; p = 0.25, Fig 5) [14,15,23], trail marking test A (SMD, -0.03; 95% CI -0.34 to 0.28; p = 0.87, Fig 5) [15,24] or trail marking test B (SMD, -0.20; 95% CI -0.65 to 0.25; p = 0.38, Fig 5) [15,24,26].

Bottom Line: The standardized mean difference (SMD) and 95% confidence intervals (CI) of a random-effects model were calculated.The aggregated results indicate that CCP improves memory performance (SMD, 0.31; 95% CI 0.16 to 0.45; p < 0.0001) and processing speed (SMD, 0.50; 95% CI 0.14 to 0.87; p = 0.007) but not executive function (SMD, -0.12; 95% CI -0.33 to 0.09; p = 0.27).However, more studies with longer follow-ups are warranted to confirm the current findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, China.

ABSTRACT

Background: Several studies have assessed the effects of computer-based cognitive programs (CCP) in the management of age-related cognitive decline, but the role of CCP remains controversial. Therefore, this systematic review evaluated the evidence on the efficacy of CCP for age-related cognitive decline in healthy older adults.

Methods: Six electronic databases (through October 2014) were searched. The risk of bias was assessed using the Cochrane Collaboration tool. The standardized mean difference (SMD) and 95% confidence intervals (CI) of a random-effects model were calculated. The heterogeneity was assessed using the Cochran Q statistic and quantified with the I2 index.

Results: Twelve studies were included in the current review and were considered as moderate to high methodological quality. The aggregated results indicate that CCP improves memory performance (SMD, 0.31; 95% CI 0.16 to 0.45; p < 0.0001) and processing speed (SMD, 0.50; 95% CI 0.14 to 0.87; p = 0.007) but not executive function (SMD, -0.12; 95% CI -0.33 to 0.09; p = 0.27). Furthermore, there were long-term gains in memory performance (SMD, 0.59; 95% CI 0.13 to 1.05; p = 0.01).

Conclusion: CCP may be a valid complementary and alternative therapy for age-related cognitive decline, especially for memory performance and processing speed. However, more studies with longer follow-ups are warranted to confirm the current findings.

No MeSH data available.


Related in: MedlinePlus