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Computer-Based Cognitive Programs for Improvement of Memory, Processing Speed and Executive Function during Age-Related Cognitive Decline: A Meta-Analysis.

Shao YK, Mang J, Li PL, Wang J, Deng T, Xu ZX - PLoS ONE (2015)

Bottom Line: The standardized mean difference (SMD) and 95% confidence intervals (CI) of a random-effects model were calculated.The aggregated results indicate that CCP improves memory performance (SMD, 0.31; 95% CI 0.16 to 0.45; p < 0.0001) and processing speed (SMD, 0.50; 95% CI 0.14 to 0.87; p = 0.007) but not executive function (SMD, -0.12; 95% CI -0.33 to 0.09; p = 0.27).However, more studies with longer follow-ups are warranted to confirm the current findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, China.

ABSTRACT

Background: Several studies have assessed the effects of computer-based cognitive programs (CCP) in the management of age-related cognitive decline, but the role of CCP remains controversial. Therefore, this systematic review evaluated the evidence on the efficacy of CCP for age-related cognitive decline in healthy older adults.

Methods: Six electronic databases (through October 2014) were searched. The risk of bias was assessed using the Cochrane Collaboration tool. The standardized mean difference (SMD) and 95% confidence intervals (CI) of a random-effects model were calculated. The heterogeneity was assessed using the Cochran Q statistic and quantified with the I2 index.

Results: Twelve studies were included in the current review and were considered as moderate to high methodological quality. The aggregated results indicate that CCP improves memory performance (SMD, 0.31; 95% CI 0.16 to 0.45; p < 0.0001) and processing speed (SMD, 0.50; 95% CI 0.14 to 0.87; p = 0.007) but not executive function (SMD, -0.12; 95% CI -0.33 to 0.09; p = 0.27). Furthermore, there were long-term gains in memory performance (SMD, 0.59; 95% CI 0.13 to 1.05; p = 0.01).

Conclusion: CCP may be a valid complementary and alternative therapy for age-related cognitive decline, especially for memory performance and processing speed. However, more studies with longer follow-ups are warranted to confirm the current findings.

No MeSH data available.


Related in: MedlinePlus

Risk of bias.Red (-): high risk of bias; Yellow (?): unclear risk of bias; Green (+): low risk of bias.
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pone.0130831.g002: Risk of bias.Red (-): high risk of bias; Yellow (?): unclear risk of bias; Green (+): low risk of bias.

Mentions: The risk of bias in the individual studies is presented in Fig 2. In total, 5 trials [16,22,23,25,26] reported adequate methods of random sequence generation and allocation concealment, and the other studies were unclear [14,15,17,18,24,27,28]. Most trials (83%) [14–18,22,23,25,26,28] used independent outcome assessors who were unaware of the group assignment. Although 3 studies were at high risk for bias [14,17,18], 8 trials (67%) [15,16,22–27] blinded the participants. For incomplete outcome data, all trials [14–18,22–28] were at low risk. 5 trials [17,23,25–27] were at low risk for selective reporting. In assessing the bias, necessary information was supplemented or clarified by contacting study-authors, especially for selective reporting [23,25,26].


Computer-Based Cognitive Programs for Improvement of Memory, Processing Speed and Executive Function during Age-Related Cognitive Decline: A Meta-Analysis.

Shao YK, Mang J, Li PL, Wang J, Deng T, Xu ZX - PLoS ONE (2015)

Risk of bias.Red (-): high risk of bias; Yellow (?): unclear risk of bias; Green (+): low risk of bias.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476706&req=5

pone.0130831.g002: Risk of bias.Red (-): high risk of bias; Yellow (?): unclear risk of bias; Green (+): low risk of bias.
Mentions: The risk of bias in the individual studies is presented in Fig 2. In total, 5 trials [16,22,23,25,26] reported adequate methods of random sequence generation and allocation concealment, and the other studies were unclear [14,15,17,18,24,27,28]. Most trials (83%) [14–18,22,23,25,26,28] used independent outcome assessors who were unaware of the group assignment. Although 3 studies were at high risk for bias [14,17,18], 8 trials (67%) [15,16,22–27] blinded the participants. For incomplete outcome data, all trials [14–18,22–28] were at low risk. 5 trials [17,23,25–27] were at low risk for selective reporting. In assessing the bias, necessary information was supplemented or clarified by contacting study-authors, especially for selective reporting [23,25,26].

Bottom Line: The standardized mean difference (SMD) and 95% confidence intervals (CI) of a random-effects model were calculated.The aggregated results indicate that CCP improves memory performance (SMD, 0.31; 95% CI 0.16 to 0.45; p < 0.0001) and processing speed (SMD, 0.50; 95% CI 0.14 to 0.87; p = 0.007) but not executive function (SMD, -0.12; 95% CI -0.33 to 0.09; p = 0.27).However, more studies with longer follow-ups are warranted to confirm the current findings.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, China.

ABSTRACT

Background: Several studies have assessed the effects of computer-based cognitive programs (CCP) in the management of age-related cognitive decline, but the role of CCP remains controversial. Therefore, this systematic review evaluated the evidence on the efficacy of CCP for age-related cognitive decline in healthy older adults.

Methods: Six electronic databases (through October 2014) were searched. The risk of bias was assessed using the Cochrane Collaboration tool. The standardized mean difference (SMD) and 95% confidence intervals (CI) of a random-effects model were calculated. The heterogeneity was assessed using the Cochran Q statistic and quantified with the I2 index.

Results: Twelve studies were included in the current review and were considered as moderate to high methodological quality. The aggregated results indicate that CCP improves memory performance (SMD, 0.31; 95% CI 0.16 to 0.45; p < 0.0001) and processing speed (SMD, 0.50; 95% CI 0.14 to 0.87; p = 0.007) but not executive function (SMD, -0.12; 95% CI -0.33 to 0.09; p = 0.27). Furthermore, there were long-term gains in memory performance (SMD, 0.59; 95% CI 0.13 to 1.05; p = 0.01).

Conclusion: CCP may be a valid complementary and alternative therapy for age-related cognitive decline, especially for memory performance and processing speed. However, more studies with longer follow-ups are warranted to confirm the current findings.

No MeSH data available.


Related in: MedlinePlus