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L-Arginine and SDMA Serum Concentrations Are Associated with Subclinical Atherosclerosis in the Study of Health in Pomerania (SHIP).

Bahls M, Friedrich N, Atzler D, Felix SB, Nauck MA, Böger RH, Völzke H, Schwedhelm E, Dörr M - PLoS ONE (2015)

Bottom Line: SDMA tertiles were significantly positively associated with larger cIMT among subjects with high SDMA levels [>66th: 0.82 (95%-CI 0.80; 0.85) mm].No relation was found for ADMA and atherosclerosis.In conclusion, the hypothesis of a positive association between SDMA with an increased cIMT was confirmed.

View Article: PubMed Central - PubMed

Affiliation: University Medicine Greifswald, Department of Internal Medicine B, Greifswald, Germany; DZHK-German Centre for Cardiovascular Research, partner site Greifswald, Greifswald, Germany.

ABSTRACT

Objective: Even though ˪-arginine (ARG) derivatives can predict cardiovascular mortality, their role as atherosclerotic biomarkers is unclear. We tested the hypothesis if asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and the sum of both (DMA) are positively, while ARG and ARG/ADMA ratio are inversely associated with carotid intima-media thickness (cIMT) and atherosclerotic plaque in the carotid artery.

Approach and results: Cross-sectional data of 1999 subjects (age: 45-81 years; 48.2% ♀) from the population-based Study of Health in Pomerania (SHIP-0) was used. Analysis of variance and logistic regression models were calculated and all adjusted models were corrected for sex, age, smoking status, waist-to-hip ratio and estimated glomerular filtration rate. Increased cIMT (>75th age-sex specific percentile) was found in 517 subjects (25.7%), while atherosclerotic plaque was detected in 1413 subjects (70.4%). SDMA tertiles were significantly positively associated with larger cIMT among subjects with high SDMA levels [>66th: 0.82 (95%-CI 0.80; 0.85) mm]. High SDMA levels were related to a higher odds ratio (OR) of increased cIMT [OR 1.39 (95%-CI 1.08; 1.79)]. Furthermore, ARG was positively associated with atherosclerotic plaques [OR 1.41 (95%-CI 1.07; 1.85)]. No relation was found for ADMA and atherosclerosis.

Conclusions: In conclusion, the hypothesis of a positive association between SDMA with an increased cIMT was confirmed. Unexpectedly, ARG was positively related to atherosclerotic plaque. In view of these inconsistent findings, the impact of ARG derivatives as atherosclerotic biomarkers deserves further research.

No MeSH data available.


Related in: MedlinePlus

Estimated mean of cIMT with 95%-CI by ADMA (A), SDMA (B), and ARG (C).Multivariate analyses of variance were adjusted for age, sex, WHR, smoking, physical activity and eGFR. Post hoc comparison adjusted for multiple testing using Tukey. # P < 0.10 in post-hoc comparison. (cIMT indicates carotid intima-media thickness; ADMA, asymmetric dimethylarginine; SDMA, symmetric dimethylarginine; ARG, ˪-Arginine).
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pone.0131293.g001: Estimated mean of cIMT with 95%-CI by ADMA (A), SDMA (B), and ARG (C).Multivariate analyses of variance were adjusted for age, sex, WHR, smoking, physical activity and eGFR. Post hoc comparison adjusted for multiple testing using Tukey. # P < 0.10 in post-hoc comparison. (cIMT indicates carotid intima-media thickness; ADMA, asymmetric dimethylarginine; SDMA, symmetric dimethylarginine; ARG, ˪-Arginine).

Mentions: In multivariable ANOVA with categorized ARG derivative serum SDMA concentration tertiles were related to cIMT (P = 0.07). Tukey adjusted post-hoc analysis identified higher cIMT in the group with high SDMA concentrations compared to the medium tertile (P < 0.10; Fig 1) [<33rd: 0.82 (95%-CI 0.79, 0.84) mm, 33rd–66th: 0.78 (95%-CI 0.76, 0.81) mm, >66th: 0.82 (95%-CI 0.79, 0.85) mm]. No significant differences in cIMT between groups were observed for tertiles of the ADMA and ARG [Fig 1; ADMA: <33rd: 0.81 (95%-CI 0.78, 0.83) mm; 33rd–66th: 0.79 (0.77, 0.82) mm; >66th: 0.82 (95%-CI 0.79, 0.84) mm; ARG: <33rd: 0.79 (95%-CI 0.77, 0.82) mm; 33rd–66th: 0.81 (95%-CI 0.78,0.84) mm; >66th: 0.81 (95%-CI 0.79; 0.84) mm] as well as the ARG/ADMA ratio and DMA [Fig 2; ARG/ADMA ratio: <33rd: 0.80 (95%-CI 0.77, 0.83) mm; 33rd–66th: 0.79 (95%-CI 0.77, 0.82) mm; >66th: 0.79 (95%-CI 0.77, 0.82) mm; DMA: <33rd: 0.81 (95%-CI 0.78, 0.83) mm; 33rd–66th: 0.79 (95%-CI 0.77, 0.82) mm; >66th: 0.81 (95%-CI 0.79, 0.84) mm].


L-Arginine and SDMA Serum Concentrations Are Associated with Subclinical Atherosclerosis in the Study of Health in Pomerania (SHIP).

Bahls M, Friedrich N, Atzler D, Felix SB, Nauck MA, Böger RH, Völzke H, Schwedhelm E, Dörr M - PLoS ONE (2015)

Estimated mean of cIMT with 95%-CI by ADMA (A), SDMA (B), and ARG (C).Multivariate analyses of variance were adjusted for age, sex, WHR, smoking, physical activity and eGFR. Post hoc comparison adjusted for multiple testing using Tukey. # P < 0.10 in post-hoc comparison. (cIMT indicates carotid intima-media thickness; ADMA, asymmetric dimethylarginine; SDMA, symmetric dimethylarginine; ARG, ˪-Arginine).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476678&req=5

pone.0131293.g001: Estimated mean of cIMT with 95%-CI by ADMA (A), SDMA (B), and ARG (C).Multivariate analyses of variance were adjusted for age, sex, WHR, smoking, physical activity and eGFR. Post hoc comparison adjusted for multiple testing using Tukey. # P < 0.10 in post-hoc comparison. (cIMT indicates carotid intima-media thickness; ADMA, asymmetric dimethylarginine; SDMA, symmetric dimethylarginine; ARG, ˪-Arginine).
Mentions: In multivariable ANOVA with categorized ARG derivative serum SDMA concentration tertiles were related to cIMT (P = 0.07). Tukey adjusted post-hoc analysis identified higher cIMT in the group with high SDMA concentrations compared to the medium tertile (P < 0.10; Fig 1) [<33rd: 0.82 (95%-CI 0.79, 0.84) mm, 33rd–66th: 0.78 (95%-CI 0.76, 0.81) mm, >66th: 0.82 (95%-CI 0.79, 0.85) mm]. No significant differences in cIMT between groups were observed for tertiles of the ADMA and ARG [Fig 1; ADMA: <33rd: 0.81 (95%-CI 0.78, 0.83) mm; 33rd–66th: 0.79 (0.77, 0.82) mm; >66th: 0.82 (95%-CI 0.79, 0.84) mm; ARG: <33rd: 0.79 (95%-CI 0.77, 0.82) mm; 33rd–66th: 0.81 (95%-CI 0.78,0.84) mm; >66th: 0.81 (95%-CI 0.79; 0.84) mm] as well as the ARG/ADMA ratio and DMA [Fig 2; ARG/ADMA ratio: <33rd: 0.80 (95%-CI 0.77, 0.83) mm; 33rd–66th: 0.79 (95%-CI 0.77, 0.82) mm; >66th: 0.79 (95%-CI 0.77, 0.82) mm; DMA: <33rd: 0.81 (95%-CI 0.78, 0.83) mm; 33rd–66th: 0.79 (95%-CI 0.77, 0.82) mm; >66th: 0.81 (95%-CI 0.79, 0.84) mm].

Bottom Line: SDMA tertiles were significantly positively associated with larger cIMT among subjects with high SDMA levels [>66th: 0.82 (95%-CI 0.80; 0.85) mm].No relation was found for ADMA and atherosclerosis.In conclusion, the hypothesis of a positive association between SDMA with an increased cIMT was confirmed.

View Article: PubMed Central - PubMed

Affiliation: University Medicine Greifswald, Department of Internal Medicine B, Greifswald, Germany; DZHK-German Centre for Cardiovascular Research, partner site Greifswald, Greifswald, Germany.

ABSTRACT

Objective: Even though ˪-arginine (ARG) derivatives can predict cardiovascular mortality, their role as atherosclerotic biomarkers is unclear. We tested the hypothesis if asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and the sum of both (DMA) are positively, while ARG and ARG/ADMA ratio are inversely associated with carotid intima-media thickness (cIMT) and atherosclerotic plaque in the carotid artery.

Approach and results: Cross-sectional data of 1999 subjects (age: 45-81 years; 48.2% ♀) from the population-based Study of Health in Pomerania (SHIP-0) was used. Analysis of variance and logistic regression models were calculated and all adjusted models were corrected for sex, age, smoking status, waist-to-hip ratio and estimated glomerular filtration rate. Increased cIMT (>75th age-sex specific percentile) was found in 517 subjects (25.7%), while atherosclerotic plaque was detected in 1413 subjects (70.4%). SDMA tertiles were significantly positively associated with larger cIMT among subjects with high SDMA levels [>66th: 0.82 (95%-CI 0.80; 0.85) mm]. High SDMA levels were related to a higher odds ratio (OR) of increased cIMT [OR 1.39 (95%-CI 1.08; 1.79)]. Furthermore, ARG was positively associated with atherosclerotic plaques [OR 1.41 (95%-CI 1.07; 1.85)]. No relation was found for ADMA and atherosclerosis.

Conclusions: In conclusion, the hypothesis of a positive association between SDMA with an increased cIMT was confirmed. Unexpectedly, ARG was positively related to atherosclerotic plaque. In view of these inconsistent findings, the impact of ARG derivatives as atherosclerotic biomarkers deserves further research.

No MeSH data available.


Related in: MedlinePlus