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Nitrogen Dioxide Sterilization in Low-Resource Environments: A Feasibility Study.

Shomali M, Opie D, Avasthi T, Trilling A - PLoS ONE (2015)

Bottom Line: Access to sterilization is a critical need for global healthcare, as it is one of the prerequisites for safe surgical care.If developed and deployed, NO2 sterilization technology will have the twin benefits of reducing healthcare acquired infections and limiting a major constraint for access to surgical care on a global scale.Additional benefits are achieved in reducing costs and biohazard waste generated by current health care initiatives that rely primarily on disposable kits, increasing the effectiveness and outreach of these initiatives.

View Article: PubMed Central - PubMed

Affiliation: Eniware LLC, Washington D.C., United States of America.

ABSTRACT
Access to sterilization is a critical need for global healthcare, as it is one of the prerequisites for safe surgical care. Lack of sterilization capability has driven up healthcare infection rates as well as limited access to healthcare, especially in low-resource environments. Sterilization technology has for the most part been static and none of the established sterilization methods has been so far successfully adapted for use in low-resource environments on a large scale. It is evident that healthcare facilities in low-resource settings require reliable, deployable, durable, affordable, easily operable sterilization equipment that can operate independently of scarce resources. Recently commercialized nitrogen dioxide (NO2) sterilization technology was analyzed and adapted into a form factor suitable for use in low-resource environments. Lab testing was conducted in microbiological testing facilities simulating low-resource environments and in accordance with the requirements of the international sterilization standard ANSI/AAMI/ISO 14937 to assess effectiveness of the device and process. The feasibility of a portable sterilizer based on nitrogen dioxide has been demonstrated, showing that sterilization of medical instruments can occur in a form factor suitable for use in low-resource environments. If developed and deployed, NO2 sterilization technology will have the twin benefits of reducing healthcare acquired infections and limiting a major constraint for access to surgical care on a global scale. Additional benefits are achieved in reducing costs and biohazard waste generated by current health care initiatives that rely primarily on disposable kits, increasing the effectiveness and outreach of these initiatives.

No MeSH data available.


Related in: MedlinePlus

The Sterilization Cycle With Passive Aeration.After dosing with NO2, the sterilant is absorbed by the scrubber media in the case. The cycle ends when the sterilant concentration has returned to a safe level.
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pone.0130043.g002: The Sterilization Cycle With Passive Aeration.After dosing with NO2, the sterilant is absorbed by the scrubber media in the case. The cycle ends when the sterilant concentration has returned to a safe level.

Mentions: The NO2 dose with passive aeration is shown in Fig 2. The graph shows the initial relative humidity, followed by the dosing with NO2, and then absorption of the sterilant by the scrubber media. The cycle ends when the sterilant level returns to a safe level, which requires between three to eight hours to complete, depending on the exposure requirements of the cycle. Sterility of the instruments is maintained as long as the case remains closed, so the sterilization cycle can be left to run overnight.


Nitrogen Dioxide Sterilization in Low-Resource Environments: A Feasibility Study.

Shomali M, Opie D, Avasthi T, Trilling A - PLoS ONE (2015)

The Sterilization Cycle With Passive Aeration.After dosing with NO2, the sterilant is absorbed by the scrubber media in the case. The cycle ends when the sterilant concentration has returned to a safe level.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476675&req=5

pone.0130043.g002: The Sterilization Cycle With Passive Aeration.After dosing with NO2, the sterilant is absorbed by the scrubber media in the case. The cycle ends when the sterilant concentration has returned to a safe level.
Mentions: The NO2 dose with passive aeration is shown in Fig 2. The graph shows the initial relative humidity, followed by the dosing with NO2, and then absorption of the sterilant by the scrubber media. The cycle ends when the sterilant level returns to a safe level, which requires between three to eight hours to complete, depending on the exposure requirements of the cycle. Sterility of the instruments is maintained as long as the case remains closed, so the sterilization cycle can be left to run overnight.

Bottom Line: Access to sterilization is a critical need for global healthcare, as it is one of the prerequisites for safe surgical care.If developed and deployed, NO2 sterilization technology will have the twin benefits of reducing healthcare acquired infections and limiting a major constraint for access to surgical care on a global scale.Additional benefits are achieved in reducing costs and biohazard waste generated by current health care initiatives that rely primarily on disposable kits, increasing the effectiveness and outreach of these initiatives.

View Article: PubMed Central - PubMed

Affiliation: Eniware LLC, Washington D.C., United States of America.

ABSTRACT
Access to sterilization is a critical need for global healthcare, as it is one of the prerequisites for safe surgical care. Lack of sterilization capability has driven up healthcare infection rates as well as limited access to healthcare, especially in low-resource environments. Sterilization technology has for the most part been static and none of the established sterilization methods has been so far successfully adapted for use in low-resource environments on a large scale. It is evident that healthcare facilities in low-resource settings require reliable, deployable, durable, affordable, easily operable sterilization equipment that can operate independently of scarce resources. Recently commercialized nitrogen dioxide (NO2) sterilization technology was analyzed and adapted into a form factor suitable for use in low-resource environments. Lab testing was conducted in microbiological testing facilities simulating low-resource environments and in accordance with the requirements of the international sterilization standard ANSI/AAMI/ISO 14937 to assess effectiveness of the device and process. The feasibility of a portable sterilizer based on nitrogen dioxide has been demonstrated, showing that sterilization of medical instruments can occur in a form factor suitable for use in low-resource environments. If developed and deployed, NO2 sterilization technology will have the twin benefits of reducing healthcare acquired infections and limiting a major constraint for access to surgical care on a global scale. Additional benefits are achieved in reducing costs and biohazard waste generated by current health care initiatives that rely primarily on disposable kits, increasing the effectiveness and outreach of these initiatives.

No MeSH data available.


Related in: MedlinePlus