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Serum CD121a (Interleukin 1 Receptor, Type I): A Potential Novel Inflammatory Marker for Coronary Heart Disease.

Liu Z, Zhang M, Wu J, Zhou P, Liu Y, Wu Y, Yang Y, Lu X - PLoS ONE (2015)

Bottom Line: Patients with CHD had significantly higher levels of CD121a.The odds ratios for CHD according to increasing CD121a quartiles were 1.00, 1.47 [95% confidence interval (CI): 0.79-2.72], 2.67 (95% CI: 1.47-4.84), and 4.71 (95% CI: 2.65-8.37) in an age- and sex-adjusted model, compared to 1.00, 1.48 (95% CI: 0.70-3.14), 2.25 (95% CI: 1.10-4.62), and 4.39 (95% CI: 2.19-8.79) in a model that was adjusted for multiple covariates.Together, the significant increase in CD121a levels among CHD patients suggests that it may be a novel inflammatory marker for predicting CHD.

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.

ABSTRACT
Inflammation is now believed to be responsible for coronary heart disease (CHD). This belief has stimulated the evaluation of various inflammatory markers for predicting CHD. This study was designed to investigate the association between four inflammatory cytokines (CD121a, interleukin [IL]-1β, IL-8, and IL-11) and CHD. Here, we evaluated 443 patients with CHD and 160 CHD-free controls who underwent coronary angiography. Cytokines were evaluated using flow cytometry, and statistical analyses were performed to investigate the association between cytokine levels and the risk of CHD. Patients with CHD had significantly higher levels of CD121a. The odds ratios for CHD according to increasing CD121a quartiles were 1.00, 1.47 [95% confidence interval (CI): 0.79-2.72], 2.67 (95% CI: 1.47-4.84), and 4.71 (95% CI: 2.65-8.37) in an age- and sex-adjusted model, compared to 1.00, 1.48 (95% CI: 0.70-3.14), 2.25 (95% CI: 1.10-4.62), and 4.39 (95% CI: 2.19-8.79) in a model that was adjusted for multiple covariates. A comparison of the stable angina, unstable angina, and acute myocardial infarction (AMI) subgroups revealed that patients with AMI had the highest CD121a levels, although IL-1β levels were similar across all groups. IL-8 levels were also increased in AMI patients, and IL-11 levels were higher in CHD patients than in non-CHD patients. Correlation analysis revealed a positive association between CD121a, IL-8, and the Gensini score. Together, the significant increase in CD121a levels among CHD patients suggests that it may be a novel inflammatory marker for predicting CHD.

No MeSH data available.


Related in: MedlinePlus

Receiver operating characteristic curves for the diagnostic accuracy of cytokines for coronary heart disease.(A) CD121a, (B) IL-1β, (C) IL-8, and (D) IL-11. AUC, area under the curve.
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pone.0131086.g003: Receiver operating characteristic curves for the diagnostic accuracy of cytokines for coronary heart disease.(A) CD121a, (B) IL-1β, (C) IL-8, and (D) IL-11. AUC, area under the curve.

Mentions: Finally, we conducted ROC curve analysis to identify the diagnostic accuracy of these cytokines for CHD. A CD121a level of 1,487.84 pg/mL demonstrated 74.3% sensitivity and 55% specificity (Fig 3A) for CHD, and an IL-11 level of 42.42 pg/mL demonstrated 67.9% sensitivity and 44.4% specificity (Fig 3D) for CHD. The areas under the curve for CD121a and IL-11 in CHD were 0.69 and 0.56, respectively. IL-1β and IL-8 had no significantly diagnostic value for CHD (Fig 3B and 3C).


Serum CD121a (Interleukin 1 Receptor, Type I): A Potential Novel Inflammatory Marker for Coronary Heart Disease.

Liu Z, Zhang M, Wu J, Zhou P, Liu Y, Wu Y, Yang Y, Lu X - PLoS ONE (2015)

Receiver operating characteristic curves for the diagnostic accuracy of cytokines for coronary heart disease.(A) CD121a, (B) IL-1β, (C) IL-8, and (D) IL-11. AUC, area under the curve.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476662&req=5

pone.0131086.g003: Receiver operating characteristic curves for the diagnostic accuracy of cytokines for coronary heart disease.(A) CD121a, (B) IL-1β, (C) IL-8, and (D) IL-11. AUC, area under the curve.
Mentions: Finally, we conducted ROC curve analysis to identify the diagnostic accuracy of these cytokines for CHD. A CD121a level of 1,487.84 pg/mL demonstrated 74.3% sensitivity and 55% specificity (Fig 3A) for CHD, and an IL-11 level of 42.42 pg/mL demonstrated 67.9% sensitivity and 44.4% specificity (Fig 3D) for CHD. The areas under the curve for CD121a and IL-11 in CHD were 0.69 and 0.56, respectively. IL-1β and IL-8 had no significantly diagnostic value for CHD (Fig 3B and 3C).

Bottom Line: Patients with CHD had significantly higher levels of CD121a.The odds ratios for CHD according to increasing CD121a quartiles were 1.00, 1.47 [95% confidence interval (CI): 0.79-2.72], 2.67 (95% CI: 1.47-4.84), and 4.71 (95% CI: 2.65-8.37) in an age- and sex-adjusted model, compared to 1.00, 1.48 (95% CI: 0.70-3.14), 2.25 (95% CI: 1.10-4.62), and 4.39 (95% CI: 2.19-8.79) in a model that was adjusted for multiple covariates.Together, the significant increase in CD121a levels among CHD patients suggests that it may be a novel inflammatory marker for predicting CHD.

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.

ABSTRACT
Inflammation is now believed to be responsible for coronary heart disease (CHD). This belief has stimulated the evaluation of various inflammatory markers for predicting CHD. This study was designed to investigate the association between four inflammatory cytokines (CD121a, interleukin [IL]-1β, IL-8, and IL-11) and CHD. Here, we evaluated 443 patients with CHD and 160 CHD-free controls who underwent coronary angiography. Cytokines were evaluated using flow cytometry, and statistical analyses were performed to investigate the association between cytokine levels and the risk of CHD. Patients with CHD had significantly higher levels of CD121a. The odds ratios for CHD according to increasing CD121a quartiles were 1.00, 1.47 [95% confidence interval (CI): 0.79-2.72], 2.67 (95% CI: 1.47-4.84), and 4.71 (95% CI: 2.65-8.37) in an age- and sex-adjusted model, compared to 1.00, 1.48 (95% CI: 0.70-3.14), 2.25 (95% CI: 1.10-4.62), and 4.39 (95% CI: 2.19-8.79) in a model that was adjusted for multiple covariates. A comparison of the stable angina, unstable angina, and acute myocardial infarction (AMI) subgroups revealed that patients with AMI had the highest CD121a levels, although IL-1β levels were similar across all groups. IL-8 levels were also increased in AMI patients, and IL-11 levels were higher in CHD patients than in non-CHD patients. Correlation analysis revealed a positive association between CD121a, IL-8, and the Gensini score. Together, the significant increase in CD121a levels among CHD patients suggests that it may be a novel inflammatory marker for predicting CHD.

No MeSH data available.


Related in: MedlinePlus