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Serum CD121a (Interleukin 1 Receptor, Type I): A Potential Novel Inflammatory Marker for Coronary Heart Disease.

Liu Z, Zhang M, Wu J, Zhou P, Liu Y, Wu Y, Yang Y, Lu X - PLoS ONE (2015)

Bottom Line: Patients with CHD had significantly higher levels of CD121a.The odds ratios for CHD according to increasing CD121a quartiles were 1.00, 1.47 [95% confidence interval (CI): 0.79-2.72], 2.67 (95% CI: 1.47-4.84), and 4.71 (95% CI: 2.65-8.37) in an age- and sex-adjusted model, compared to 1.00, 1.48 (95% CI: 0.70-3.14), 2.25 (95% CI: 1.10-4.62), and 4.39 (95% CI: 2.19-8.79) in a model that was adjusted for multiple covariates.Together, the significant increase in CD121a levels among CHD patients suggests that it may be a novel inflammatory marker for predicting CHD.

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.

ABSTRACT
Inflammation is now believed to be responsible for coronary heart disease (CHD). This belief has stimulated the evaluation of various inflammatory markers for predicting CHD. This study was designed to investigate the association between four inflammatory cytokines (CD121a, interleukin [IL]-1β, IL-8, and IL-11) and CHD. Here, we evaluated 443 patients with CHD and 160 CHD-free controls who underwent coronary angiography. Cytokines were evaluated using flow cytometry, and statistical analyses were performed to investigate the association between cytokine levels and the risk of CHD. Patients with CHD had significantly higher levels of CD121a. The odds ratios for CHD according to increasing CD121a quartiles were 1.00, 1.47 [95% confidence interval (CI): 0.79-2.72], 2.67 (95% CI: 1.47-4.84), and 4.71 (95% CI: 2.65-8.37) in an age- and sex-adjusted model, compared to 1.00, 1.48 (95% CI: 0.70-3.14), 2.25 (95% CI: 1.10-4.62), and 4.39 (95% CI: 2.19-8.79) in a model that was adjusted for multiple covariates. A comparison of the stable angina, unstable angina, and acute myocardial infarction (AMI) subgroups revealed that patients with AMI had the highest CD121a levels, although IL-1β levels were similar across all groups. IL-8 levels were also increased in AMI patients, and IL-11 levels were higher in CHD patients than in non-CHD patients. Correlation analysis revealed a positive association between CD121a, IL-8, and the Gensini score. Together, the significant increase in CD121a levels among CHD patients suggests that it may be a novel inflammatory marker for predicting CHD.

No MeSH data available.


Related in: MedlinePlus

Comparison of cytokine levels among the various groups.(A) CD121a levels among patients with coronary heart disease (CHD) and controls. (B) CD121a levels among the CHD subgroups and controls. (C) IL-1β levels among patients with CHD and controls. (D) IL-1β levels among the CHD subgroups and controls. (E) IL-8 levels among patients with CHD and controls. (F) IL-8 levels among the CHD subgroups and controls. (G) IL-11 levels among patients with CHD and controls. (H) IL-11 levels among the CHD subgroups and controls. Values are medians (25th and 75th percentiles). *P < 0.05 vs. the control group, #P < 0.05 vs. the stable angina (SA) group, §P < 0.05 vs. the unstable angina (UA) group. AMI, acute myocardial infarction.
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pone.0131086.g001: Comparison of cytokine levels among the various groups.(A) CD121a levels among patients with coronary heart disease (CHD) and controls. (B) CD121a levels among the CHD subgroups and controls. (C) IL-1β levels among patients with CHD and controls. (D) IL-1β levels among the CHD subgroups and controls. (E) IL-8 levels among patients with CHD and controls. (F) IL-8 levels among the CHD subgroups and controls. (G) IL-11 levels among patients with CHD and controls. (H) IL-11 levels among the CHD subgroups and controls. Values are medians (25th and 75th percentiles). *P < 0.05 vs. the control group, #P < 0.05 vs. the stable angina (SA) group, §P < 0.05 vs. the unstable angina (UA) group. AMI, acute myocardial infarction.

Mentions: Interestingly, significantly higher levels of CD121a were observed in the CHD patients compared to the controls (Fig 1A). In addition, the SA, UA, and AMI subgroups all had significantly higher levels of CD121a compared to the controls (Fig 1B). Among the subgroups, patients with AMI had the highest CD121a levels. However, no differences in IL-1β levels were observed across the various groups (Fig 1C and 1D). Although patients with AMI had significantly increased levels of IL-8, the levels in the CHD group were similar to those in the control group (Fig 1E and 1F). Furthermore, significantly increased levels of IL-11 were observed in the CHD and UA groups compared to controls (Fig 1G and 1H).


Serum CD121a (Interleukin 1 Receptor, Type I): A Potential Novel Inflammatory Marker for Coronary Heart Disease.

Liu Z, Zhang M, Wu J, Zhou P, Liu Y, Wu Y, Yang Y, Lu X - PLoS ONE (2015)

Comparison of cytokine levels among the various groups.(A) CD121a levels among patients with coronary heart disease (CHD) and controls. (B) CD121a levels among the CHD subgroups and controls. (C) IL-1β levels among patients with CHD and controls. (D) IL-1β levels among the CHD subgroups and controls. (E) IL-8 levels among patients with CHD and controls. (F) IL-8 levels among the CHD subgroups and controls. (G) IL-11 levels among patients with CHD and controls. (H) IL-11 levels among the CHD subgroups and controls. Values are medians (25th and 75th percentiles). *P < 0.05 vs. the control group, #P < 0.05 vs. the stable angina (SA) group, §P < 0.05 vs. the unstable angina (UA) group. AMI, acute myocardial infarction.
© Copyright Policy
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC4476662&req=5

pone.0131086.g001: Comparison of cytokine levels among the various groups.(A) CD121a levels among patients with coronary heart disease (CHD) and controls. (B) CD121a levels among the CHD subgroups and controls. (C) IL-1β levels among patients with CHD and controls. (D) IL-1β levels among the CHD subgroups and controls. (E) IL-8 levels among patients with CHD and controls. (F) IL-8 levels among the CHD subgroups and controls. (G) IL-11 levels among patients with CHD and controls. (H) IL-11 levels among the CHD subgroups and controls. Values are medians (25th and 75th percentiles). *P < 0.05 vs. the control group, #P < 0.05 vs. the stable angina (SA) group, §P < 0.05 vs. the unstable angina (UA) group. AMI, acute myocardial infarction.
Mentions: Interestingly, significantly higher levels of CD121a were observed in the CHD patients compared to the controls (Fig 1A). In addition, the SA, UA, and AMI subgroups all had significantly higher levels of CD121a compared to the controls (Fig 1B). Among the subgroups, patients with AMI had the highest CD121a levels. However, no differences in IL-1β levels were observed across the various groups (Fig 1C and 1D). Although patients with AMI had significantly increased levels of IL-8, the levels in the CHD group were similar to those in the control group (Fig 1E and 1F). Furthermore, significantly increased levels of IL-11 were observed in the CHD and UA groups compared to controls (Fig 1G and 1H).

Bottom Line: Patients with CHD had significantly higher levels of CD121a.The odds ratios for CHD according to increasing CD121a quartiles were 1.00, 1.47 [95% confidence interval (CI): 0.79-2.72], 2.67 (95% CI: 1.47-4.84), and 4.71 (95% CI: 2.65-8.37) in an age- and sex-adjusted model, compared to 1.00, 1.48 (95% CI: 0.70-3.14), 2.25 (95% CI: 1.10-4.62), and 4.39 (95% CI: 2.19-8.79) in a model that was adjusted for multiple covariates.Together, the significant increase in CD121a levels among CHD patients suggests that it may be a novel inflammatory marker for predicting CHD.

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.

ABSTRACT
Inflammation is now believed to be responsible for coronary heart disease (CHD). This belief has stimulated the evaluation of various inflammatory markers for predicting CHD. This study was designed to investigate the association between four inflammatory cytokines (CD121a, interleukin [IL]-1β, IL-8, and IL-11) and CHD. Here, we evaluated 443 patients with CHD and 160 CHD-free controls who underwent coronary angiography. Cytokines were evaluated using flow cytometry, and statistical analyses were performed to investigate the association between cytokine levels and the risk of CHD. Patients with CHD had significantly higher levels of CD121a. The odds ratios for CHD according to increasing CD121a quartiles were 1.00, 1.47 [95% confidence interval (CI): 0.79-2.72], 2.67 (95% CI: 1.47-4.84), and 4.71 (95% CI: 2.65-8.37) in an age- and sex-adjusted model, compared to 1.00, 1.48 (95% CI: 0.70-3.14), 2.25 (95% CI: 1.10-4.62), and 4.39 (95% CI: 2.19-8.79) in a model that was adjusted for multiple covariates. A comparison of the stable angina, unstable angina, and acute myocardial infarction (AMI) subgroups revealed that patients with AMI had the highest CD121a levels, although IL-1β levels were similar across all groups. IL-8 levels were also increased in AMI patients, and IL-11 levels were higher in CHD patients than in non-CHD patients. Correlation analysis revealed a positive association between CD121a, IL-8, and the Gensini score. Together, the significant increase in CD121a levels among CHD patients suggests that it may be a novel inflammatory marker for predicting CHD.

No MeSH data available.


Related in: MedlinePlus