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Adjunctive Treatment with Rhodiola Crenulata in Patients with Chronic Obstructive Pulmonary Disease--A Randomized Placebo Controlled Double Blind Clinical Trial.

Chuang ML, Wu TC, Wang YT, Wang YC, Tsao TC, Wei JC, Chen CY, Lin IF - PLoS ONE (2015)

Bottom Line: Over the 12 weeks, RC was well tolerated, significantly reduced triceps skin thickness (Δ=-1 mm, p=.04), change of FEV1 (4.5%, p=.03), and improved workload (Δ=10%, p=.01); although there were no significant differences in these factors between the two groups.RC did not improve the six-minute walk test distance but significantly improved tidal breathing and ventilation efficiency, most likely through improvements in work rate.Further studies with a larger patient population are needed in order to confirm these findings.

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary Medicine and Department of Critical Care Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

ABSTRACT

Unlabelled: Chronic obstructive pulmonary disease (COPD) is a low grade systemic inflammatory disease characterized by dyspnea and exercise intolerance even under standard therapy. Rhodiola crenulata (RC) has been shown to exert anti-inflammatory effects and to enhance exercise endurance, thereby having the potential to treat COPD. In this 12-week, randomized, double-blind, placebo-controlled clinical trial, 57 patients with stable moderate-to-severe COPD aged 70±8.8 years were given RC (250 mg twice/day) (n=38) or a placebo (250 mg twice/day) (n=19) in addition to their standard regimen. There were no significant differences in anthropometrics, quality of life, lung function, six-minute walk and incremental exercise tests between the two groups at enrollment. Over the 12 weeks, RC was well tolerated, significantly reduced triceps skin thickness (Δ=-1 mm, p=.04), change of FEV1 (4.5%, p=.03), and improved workload (Δ=10%, p=.01); although there were no significant differences in these factors between the two groups. However, there were significant between-group differences in tidal volume and ventilation-CO2-output ratio at peak exercise (both p=.05), which were significantly related to peak work rate (both p<.0001). RC tended to protect against acute exacerbation of COPD (p=.1) but not other measurements. RC did not improve the six-minute walk test distance but significantly improved tidal breathing and ventilation efficiency, most likely through improvements in work rate. Further studies with a larger patient population are needed in order to confirm these findings.

Trial registration: ClinicalTrials.gov number NCT02242461.

No MeSH data available.


Related in: MedlinePlus

Flow Diagram.A total of 68 patients with chronic obstructive pulmonary disease were screened. Eleven patients were excluded, and 57 subjects were randomly allocated to the study group or control group with a 2:1 ratio. This 2:1 ratio was based on our previous experience with regards to clinical trial studies. Please refer to the text.
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pone.0128142.g001: Flow Diagram.A total of 68 patients with chronic obstructive pulmonary disease were screened. Eleven patients were excluded, and 57 subjects were randomly allocated to the study group or control group with a 2:1 ratio. This 2:1 ratio was based on our previous experience with regards to clinical trial studies. Please refer to the text.

Mentions: Of the 68 patients screened (Fig 1), 57 were enrolled, and 38 of these 57 patients were randomized into the study group and 19 into the placebo group (Table 1) (Please also see S4 File. CONSORT 2010 Checklist (2)). Five subjects dropped out from the study group and one from the placebo group, however there was no difference in dropout rate between the two groups (Table 2, p = .65).


Adjunctive Treatment with Rhodiola Crenulata in Patients with Chronic Obstructive Pulmonary Disease--A Randomized Placebo Controlled Double Blind Clinical Trial.

Chuang ML, Wu TC, Wang YT, Wang YC, Tsao TC, Wei JC, Chen CY, Lin IF - PLoS ONE (2015)

Flow Diagram.A total of 68 patients with chronic obstructive pulmonary disease were screened. Eleven patients were excluded, and 57 subjects were randomly allocated to the study group or control group with a 2:1 ratio. This 2:1 ratio was based on our previous experience with regards to clinical trial studies. Please refer to the text.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476627&req=5

pone.0128142.g001: Flow Diagram.A total of 68 patients with chronic obstructive pulmonary disease were screened. Eleven patients were excluded, and 57 subjects were randomly allocated to the study group or control group with a 2:1 ratio. This 2:1 ratio was based on our previous experience with regards to clinical trial studies. Please refer to the text.
Mentions: Of the 68 patients screened (Fig 1), 57 were enrolled, and 38 of these 57 patients were randomized into the study group and 19 into the placebo group (Table 1) (Please also see S4 File. CONSORT 2010 Checklist (2)). Five subjects dropped out from the study group and one from the placebo group, however there was no difference in dropout rate between the two groups (Table 2, p = .65).

Bottom Line: Over the 12 weeks, RC was well tolerated, significantly reduced triceps skin thickness (Δ=-1 mm, p=.04), change of FEV1 (4.5%, p=.03), and improved workload (Δ=10%, p=.01); although there were no significant differences in these factors between the two groups.RC did not improve the six-minute walk test distance but significantly improved tidal breathing and ventilation efficiency, most likely through improvements in work rate.Further studies with a larger patient population are needed in order to confirm these findings.

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary Medicine and Department of Critical Care Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

ABSTRACT

Unlabelled: Chronic obstructive pulmonary disease (COPD) is a low grade systemic inflammatory disease characterized by dyspnea and exercise intolerance even under standard therapy. Rhodiola crenulata (RC) has been shown to exert anti-inflammatory effects and to enhance exercise endurance, thereby having the potential to treat COPD. In this 12-week, randomized, double-blind, placebo-controlled clinical trial, 57 patients with stable moderate-to-severe COPD aged 70±8.8 years were given RC (250 mg twice/day) (n=38) or a placebo (250 mg twice/day) (n=19) in addition to their standard regimen. There were no significant differences in anthropometrics, quality of life, lung function, six-minute walk and incremental exercise tests between the two groups at enrollment. Over the 12 weeks, RC was well tolerated, significantly reduced triceps skin thickness (Δ=-1 mm, p=.04), change of FEV1 (4.5%, p=.03), and improved workload (Δ=10%, p=.01); although there were no significant differences in these factors between the two groups. However, there were significant between-group differences in tidal volume and ventilation-CO2-output ratio at peak exercise (both p=.05), which were significantly related to peak work rate (both p<.0001). RC tended to protect against acute exacerbation of COPD (p=.1) but not other measurements. RC did not improve the six-minute walk test distance but significantly improved tidal breathing and ventilation efficiency, most likely through improvements in work rate. Further studies with a larger patient population are needed in order to confirm these findings.

Trial registration: ClinicalTrials.gov number NCT02242461.

No MeSH data available.


Related in: MedlinePlus