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Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake.

Werling M, Fändriks L, Olbers T, Bueter M, Sjöström L, Lönroth H, Wallenius V, Stenlöf K, le Roux CW - PLoS ONE (2015)

Bottom Line: Lean tissue decreased from 55.9 (range 47.5-59.3) to 49.5 (range 41.1-54.9) kg and adipose tissue from 61 (range 56-64.6) to 27 (range 12-34.3) kg (both p<0.05).PA over 24 h did not change after surgery whereas 24 h EE and basal metabolic rate (BMR) decreased.RYGB surgery up-regulates RQ and EE after food intake resulting in an increased contribution to total EE over 24 h when corrected for total tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastrosurgical Research and Education, Sahlgrenska academy, University of Gothenburg. Department of Surgery, Sahlgrenska University Hospital/Sahlgrenska, Gothenburg, Sweden.

ABSTRACT

Objective: The mechanisms determining long-term weight maintenance after Roux-en-Y gastric bypass (RYGB) remain unclear. Cross sectional studies have suggested that enhanced energy expenditure (EE) may play a significant role and the aim of this study was to reveal the impact of RYGB on each major component constituting total EE.

Design: Six obese female subjects, without other co-morbidities, were assessed before and at 10 days, 3 and 20 months after RYGB. Indirect calorimetry in a metabolic chamber was used to assess 24 h EE at each study visit. Other measurements included body composition by DEXA, gut hormone profiles and physical activity (PA) using high sensitivity accelerometers.

Results: Median Body Mass Index decreased from 41.1 (range 39.1-44.8) at baseline to 28 kg/m2 (range 22.3-30.3) after 20 months (p<0.05). Lean tissue decreased from 55.9 (range 47.5-59.3) to 49.5 (range 41.1-54.9) kg and adipose tissue from 61 (range 56-64.6) to 27 (range 12-34.3) kg (both p<0.05). PA over 24 h did not change after surgery whereas 24 h EE and basal metabolic rate (BMR) decreased. EE after a standard meal increased after surgery when adjusted for total tissue (p<0.05). After an initial drop, RQ (respiratory quotient) had increased at 20 months, both as measured during 24 h and after food intake (p<0.05).

Conclusion: RYGB surgery up-regulates RQ and EE after food intake resulting in an increased contribution to total EE over 24 h when corrected for total tissue.

No MeSH data available.


Related in: MedlinePlus

Six female subjects assessed for energy expenditure during one hour after a 600 kcal standard meal; from 18:20 to 19:20.Assessments were performed before, visit 1, and at weight stability 20 months after, visit 4, gastric bypass surgery. Data are presented as mean values in kcal/minute and as percentage of total energy expenditure.
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pone.0129784.g004: Six female subjects assessed for energy expenditure during one hour after a 600 kcal standard meal; from 18:20 to 19:20.Assessments were performed before, visit 1, and at weight stability 20 months after, visit 4, gastric bypass surgery. Data are presented as mean values in kcal/minute and as percentage of total energy expenditure.

Mentions: MAT was defined as the postprandial energy expenditure exceeding pre-meal EE (ie BMR and NEAT). To standardise the pre-meal NEAT within the individuals only light intensity activity EE (ie NEATMETS≤2) was used in the analysis. Therefore, occasional 1 min periods with leg AU1min >50 units were omitted (see Methods). Less than 12% (median 1.7%; range 0 to 11.7%) of all pre-meal NEAT recordings at each of the 24 study visits had to be removed due to spontaneous physical activity at METS>2. The resulting NEATMETS≤2 did not differ between study visits and are shown in Table 3. Despite the significant weight loss, MAT in absolute terms did not change between pre- and postoperative weight stability recordings (ie visit 1 and 4). However, relative to 24h EE or when adjusted for total tissue, MAT was significantly higher after surgery during the first postprandial hour as shown in Fig 3 with details given in Table 3, as well as in Fig 4.


Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake.

Werling M, Fändriks L, Olbers T, Bueter M, Sjöström L, Lönroth H, Wallenius V, Stenlöf K, le Roux CW - PLoS ONE (2015)

Six female subjects assessed for energy expenditure during one hour after a 600 kcal standard meal; from 18:20 to 19:20.Assessments were performed before, visit 1, and at weight stability 20 months after, visit 4, gastric bypass surgery. Data are presented as mean values in kcal/minute and as percentage of total energy expenditure.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476618&req=5

pone.0129784.g004: Six female subjects assessed for energy expenditure during one hour after a 600 kcal standard meal; from 18:20 to 19:20.Assessments were performed before, visit 1, and at weight stability 20 months after, visit 4, gastric bypass surgery. Data are presented as mean values in kcal/minute and as percentage of total energy expenditure.
Mentions: MAT was defined as the postprandial energy expenditure exceeding pre-meal EE (ie BMR and NEAT). To standardise the pre-meal NEAT within the individuals only light intensity activity EE (ie NEATMETS≤2) was used in the analysis. Therefore, occasional 1 min periods with leg AU1min >50 units were omitted (see Methods). Less than 12% (median 1.7%; range 0 to 11.7%) of all pre-meal NEAT recordings at each of the 24 study visits had to be removed due to spontaneous physical activity at METS>2. The resulting NEATMETS≤2 did not differ between study visits and are shown in Table 3. Despite the significant weight loss, MAT in absolute terms did not change between pre- and postoperative weight stability recordings (ie visit 1 and 4). However, relative to 24h EE or when adjusted for total tissue, MAT was significantly higher after surgery during the first postprandial hour as shown in Fig 3 with details given in Table 3, as well as in Fig 4.

Bottom Line: Lean tissue decreased from 55.9 (range 47.5-59.3) to 49.5 (range 41.1-54.9) kg and adipose tissue from 61 (range 56-64.6) to 27 (range 12-34.3) kg (both p<0.05).PA over 24 h did not change after surgery whereas 24 h EE and basal metabolic rate (BMR) decreased.RYGB surgery up-regulates RQ and EE after food intake resulting in an increased contribution to total EE over 24 h when corrected for total tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastrosurgical Research and Education, Sahlgrenska academy, University of Gothenburg. Department of Surgery, Sahlgrenska University Hospital/Sahlgrenska, Gothenburg, Sweden.

ABSTRACT

Objective: The mechanisms determining long-term weight maintenance after Roux-en-Y gastric bypass (RYGB) remain unclear. Cross sectional studies have suggested that enhanced energy expenditure (EE) may play a significant role and the aim of this study was to reveal the impact of RYGB on each major component constituting total EE.

Design: Six obese female subjects, without other co-morbidities, were assessed before and at 10 days, 3 and 20 months after RYGB. Indirect calorimetry in a metabolic chamber was used to assess 24 h EE at each study visit. Other measurements included body composition by DEXA, gut hormone profiles and physical activity (PA) using high sensitivity accelerometers.

Results: Median Body Mass Index decreased from 41.1 (range 39.1-44.8) at baseline to 28 kg/m2 (range 22.3-30.3) after 20 months (p<0.05). Lean tissue decreased from 55.9 (range 47.5-59.3) to 49.5 (range 41.1-54.9) kg and adipose tissue from 61 (range 56-64.6) to 27 (range 12-34.3) kg (both p<0.05). PA over 24 h did not change after surgery whereas 24 h EE and basal metabolic rate (BMR) decreased. EE after a standard meal increased after surgery when adjusted for total tissue (p<0.05). After an initial drop, RQ (respiratory quotient) had increased at 20 months, both as measured during 24 h and after food intake (p<0.05).

Conclusion: RYGB surgery up-regulates RQ and EE after food intake resulting in an increased contribution to total EE over 24 h when corrected for total tissue.

No MeSH data available.


Related in: MedlinePlus