Limits...
Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake.

Werling M, Fändriks L, Olbers T, Bueter M, Sjöström L, Lönroth H, Wallenius V, Stenlöf K, le Roux CW - PLoS ONE (2015)

Bottom Line: Lean tissue decreased from 55.9 (range 47.5-59.3) to 49.5 (range 41.1-54.9) kg and adipose tissue from 61 (range 56-64.6) to 27 (range 12-34.3) kg (both p<0.05).PA over 24 h did not change after surgery whereas 24 h EE and basal metabolic rate (BMR) decreased.RYGB surgery up-regulates RQ and EE after food intake resulting in an increased contribution to total EE over 24 h when corrected for total tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastrosurgical Research and Education, Sahlgrenska academy, University of Gothenburg. Department of Surgery, Sahlgrenska University Hospital/Sahlgrenska, Gothenburg, Sweden.

ABSTRACT

Objective: The mechanisms determining long-term weight maintenance after Roux-en-Y gastric bypass (RYGB) remain unclear. Cross sectional studies have suggested that enhanced energy expenditure (EE) may play a significant role and the aim of this study was to reveal the impact of RYGB on each major component constituting total EE.

Design: Six obese female subjects, without other co-morbidities, were assessed before and at 10 days, 3 and 20 months after RYGB. Indirect calorimetry in a metabolic chamber was used to assess 24 h EE at each study visit. Other measurements included body composition by DEXA, gut hormone profiles and physical activity (PA) using high sensitivity accelerometers.

Results: Median Body Mass Index decreased from 41.1 (range 39.1-44.8) at baseline to 28 kg/m2 (range 22.3-30.3) after 20 months (p<0.05). Lean tissue decreased from 55.9 (range 47.5-59.3) to 49.5 (range 41.1-54.9) kg and adipose tissue from 61 (range 56-64.6) to 27 (range 12-34.3) kg (both p<0.05). PA over 24 h did not change after surgery whereas 24 h EE and basal metabolic rate (BMR) decreased. EE after a standard meal increased after surgery when adjusted for total tissue (p<0.05). After an initial drop, RQ (respiratory quotient) had increased at 20 months, both as measured during 24 h and after food intake (p<0.05).

Conclusion: RYGB surgery up-regulates RQ and EE after food intake resulting in an increased contribution to total EE over 24 h when corrected for total tissue.

No MeSH data available.


Related in: MedlinePlus

Protocol during study visits before as well as 10 days, 3 months and 20 months after gastric bypass surgery for six female study subjects.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4476618&req=5

pone.0129784.g001: Protocol during study visits before as well as 10 days, 3 months and 20 months after gastric bypass surgery for six female study subjects.

Mentions: Furthermore, in the evening before study visit 1 and 4, patients had a standardized dinner of mashed potatoes and meatballs at 19.00–20.00. Corresponding meals before visit 2 and 3 were semiliquid and contained 200 and 300 kcal respectively. The morning after these standard meals, the patient arrived to the laboratory at 07.30 after an 11h fast. Fig 1 shows the protocol during study visits.


Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake.

Werling M, Fändriks L, Olbers T, Bueter M, Sjöström L, Lönroth H, Wallenius V, Stenlöf K, le Roux CW - PLoS ONE (2015)

Protocol during study visits before as well as 10 days, 3 months and 20 months after gastric bypass surgery for six female study subjects.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476618&req=5

pone.0129784.g001: Protocol during study visits before as well as 10 days, 3 months and 20 months after gastric bypass surgery for six female study subjects.
Mentions: Furthermore, in the evening before study visit 1 and 4, patients had a standardized dinner of mashed potatoes and meatballs at 19.00–20.00. Corresponding meals before visit 2 and 3 were semiliquid and contained 200 and 300 kcal respectively. The morning after these standard meals, the patient arrived to the laboratory at 07.30 after an 11h fast. Fig 1 shows the protocol during study visits.

Bottom Line: Lean tissue decreased from 55.9 (range 47.5-59.3) to 49.5 (range 41.1-54.9) kg and adipose tissue from 61 (range 56-64.6) to 27 (range 12-34.3) kg (both p<0.05).PA over 24 h did not change after surgery whereas 24 h EE and basal metabolic rate (BMR) decreased.RYGB surgery up-regulates RQ and EE after food intake resulting in an increased contribution to total EE over 24 h when corrected for total tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastrosurgical Research and Education, Sahlgrenska academy, University of Gothenburg. Department of Surgery, Sahlgrenska University Hospital/Sahlgrenska, Gothenburg, Sweden.

ABSTRACT

Objective: The mechanisms determining long-term weight maintenance after Roux-en-Y gastric bypass (RYGB) remain unclear. Cross sectional studies have suggested that enhanced energy expenditure (EE) may play a significant role and the aim of this study was to reveal the impact of RYGB on each major component constituting total EE.

Design: Six obese female subjects, without other co-morbidities, were assessed before and at 10 days, 3 and 20 months after RYGB. Indirect calorimetry in a metabolic chamber was used to assess 24 h EE at each study visit. Other measurements included body composition by DEXA, gut hormone profiles and physical activity (PA) using high sensitivity accelerometers.

Results: Median Body Mass Index decreased from 41.1 (range 39.1-44.8) at baseline to 28 kg/m2 (range 22.3-30.3) after 20 months (p<0.05). Lean tissue decreased from 55.9 (range 47.5-59.3) to 49.5 (range 41.1-54.9) kg and adipose tissue from 61 (range 56-64.6) to 27 (range 12-34.3) kg (both p<0.05). PA over 24 h did not change after surgery whereas 24 h EE and basal metabolic rate (BMR) decreased. EE after a standard meal increased after surgery when adjusted for total tissue (p<0.05). After an initial drop, RQ (respiratory quotient) had increased at 20 months, both as measured during 24 h and after food intake (p<0.05).

Conclusion: RYGB surgery up-regulates RQ and EE after food intake resulting in an increased contribution to total EE over 24 h when corrected for total tissue.

No MeSH data available.


Related in: MedlinePlus