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Association of Lp-PLA2 Mass and Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.

Wang Y, Zhang J, Qian Y, Tang X, Ling H, Chen K, Gao P, Zhu D - PLoS ONE (2015)

Bottom Line: Lp-PLA2 mass was measured by enzyme linked immunoassay.The association of Lp-PLA2 and vascular stenosis was analyzed through multivariate logistic regression.Lp-PLA2 mass was significantly associated with isolated ICAS (OR: 2.3; 95% CI: 1.14-4.64), and concurrent stenosis (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48).

View Article: PubMed Central - PubMed

Affiliation: Research Center for Hypertension Management and Prevention in Community, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

ABSTRACT

Background and purpose: Intracranial arterial stenosis (ICAS) is a common cause of ischemic stroke in Asians, whereas whites tend to have more extracranial lesions. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been associated with ischemic stroke by a large amount of work. However, there are few studies focusing on the relationship of Lp-PLA2 and asymptomatic ICAS or extracranial arterial stenosis (ECAS). Wehereby sought to explore the relationship of Lp-PLA2 and ICAS, ECAS and concurrent stenosis in stroke-free hypertensive patients in Chinese population.

Methods: All the subjects were evaluated for the presence and severity of ICAS and ECAS through computerized tomographic angiography (CTA) covered the whole brain down to the level of aortic arch. Lp-PLA2 mass was measured by enzyme linked immunoassay. The association of Lp-PLA2 and vascular stenosis was analyzed through multivariate logistic regression.

Results: Among 414 participants, 163 (39.4%) had no ICAS or ECAS, 63 (15.2%) had ECAS only, 111 (26.8%) had ICAS only and 77 (18.6%) had concurrent extraintracranial stenosis. Lp-PLA2 mass was significantly associated with isolated ICAS (OR: 2.3; 95% CI: 1.14-4.64), and concurrent stenosis (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48). Lp-PLA2 mass was also associated with moderate to severe ICAS no matter how was the ECAS. Moreover, patients with higher Lp-PLA2 mass showed more sever ICAS and had more intracranial arterial lesions.

Conclusion: This study revealed the association of Lp-PLA2 mass with ICAS in stroke-free hypertensive patients in Chinese population. The further long-term cohort study was warranted to elucidate the concrete effect of Lp-PLA2 on the asymptomatic ICAS.

No MeSH data available.


Related in: MedlinePlus

Prevalence of moderate to severe ECAS and ICAS (%) (A) and distribution of ICAS vessels (B) according to tertiles of Lp-PLA2.ECAS, extracranial arterial stenosis; ICAS, intracranial arterial stenosis; Lp-PLA2, Lipoprotein-associated phospholipase A2.
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pone.0130473.g001: Prevalence of moderate to severe ECAS and ICAS (%) (A) and distribution of ICAS vessels (B) according to tertiles of Lp-PLA2.ECAS, extracranial arterial stenosis; ICAS, intracranial arterial stenosis; Lp-PLA2, Lipoprotein-associated phospholipase A2.

Mentions: Compared to the subjects in the lowest tertile of Lp-PLA2 mass (11.5%), more subjects in tertile 2 (13.7%) and tertile 3 (16.1%) suffered moderate to severe ICAS (P < 0.05) (Fig 1A). Moreover, patients in the highest tertile of Lp-PLA2 mass showed higher frequency of multiple ICAS (34.3%) than the lowest tertile group (27.3%) (Fig 1B). The severity or number of ECAS was not related to the Lp-PLA2 mass level.


Association of Lp-PLA2 Mass and Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.

Wang Y, Zhang J, Qian Y, Tang X, Ling H, Chen K, Gao P, Zhu D - PLoS ONE (2015)

Prevalence of moderate to severe ECAS and ICAS (%) (A) and distribution of ICAS vessels (B) according to tertiles of Lp-PLA2.ECAS, extracranial arterial stenosis; ICAS, intracranial arterial stenosis; Lp-PLA2, Lipoprotein-associated phospholipase A2.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476589&req=5

pone.0130473.g001: Prevalence of moderate to severe ECAS and ICAS (%) (A) and distribution of ICAS vessels (B) according to tertiles of Lp-PLA2.ECAS, extracranial arterial stenosis; ICAS, intracranial arterial stenosis; Lp-PLA2, Lipoprotein-associated phospholipase A2.
Mentions: Compared to the subjects in the lowest tertile of Lp-PLA2 mass (11.5%), more subjects in tertile 2 (13.7%) and tertile 3 (16.1%) suffered moderate to severe ICAS (P < 0.05) (Fig 1A). Moreover, patients in the highest tertile of Lp-PLA2 mass showed higher frequency of multiple ICAS (34.3%) than the lowest tertile group (27.3%) (Fig 1B). The severity or number of ECAS was not related to the Lp-PLA2 mass level.

Bottom Line: Lp-PLA2 mass was measured by enzyme linked immunoassay.The association of Lp-PLA2 and vascular stenosis was analyzed through multivariate logistic regression.Lp-PLA2 mass was significantly associated with isolated ICAS (OR: 2.3; 95% CI: 1.14-4.64), and concurrent stenosis (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48).

View Article: PubMed Central - PubMed

Affiliation: Research Center for Hypertension Management and Prevention in Community, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

ABSTRACT

Background and purpose: Intracranial arterial stenosis (ICAS) is a common cause of ischemic stroke in Asians, whereas whites tend to have more extracranial lesions. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been associated with ischemic stroke by a large amount of work. However, there are few studies focusing on the relationship of Lp-PLA2 and asymptomatic ICAS or extracranial arterial stenosis (ECAS). Wehereby sought to explore the relationship of Lp-PLA2 and ICAS, ECAS and concurrent stenosis in stroke-free hypertensive patients in Chinese population.

Methods: All the subjects were evaluated for the presence and severity of ICAS and ECAS through computerized tomographic angiography (CTA) covered the whole brain down to the level of aortic arch. Lp-PLA2 mass was measured by enzyme linked immunoassay. The association of Lp-PLA2 and vascular stenosis was analyzed through multivariate logistic regression.

Results: Among 414 participants, 163 (39.4%) had no ICAS or ECAS, 63 (15.2%) had ECAS only, 111 (26.8%) had ICAS only and 77 (18.6%) had concurrent extraintracranial stenosis. Lp-PLA2 mass was significantly associated with isolated ICAS (OR: 2.3; 95% CI: 1.14-4.64), and concurrent stenosis (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48). Lp-PLA2 mass was also associated with moderate to severe ICAS no matter how was the ECAS. Moreover, patients with higher Lp-PLA2 mass showed more sever ICAS and had more intracranial arterial lesions.

Conclusion: This study revealed the association of Lp-PLA2 mass with ICAS in stroke-free hypertensive patients in Chinese population. The further long-term cohort study was warranted to elucidate the concrete effect of Lp-PLA2 on the asymptomatic ICAS.

No MeSH data available.


Related in: MedlinePlus