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Prognostic Value of Circulating Tumor Cells in Ovarian Cancer: A Meta-Analysis.

Zhou Y, Bian B, Yuan X, Xie G, Ma Y, Shen L - PLoS ONE (2015)

Bottom Line: The prognostic value of the CTC status was significant in overall survival (OS) (HR, 1.61;95% CI,1.22-2.13) and progression-free survival (PFS)/disease-free survival (DFS) (HR, 1.44; 95%CI, 1.18-1.75).Furthermore, subgroup analysis revealed that the value of CTC status in OS was significant in "RT-PCR" subgroup (HR, 2.02; 95% CI, 1.34-3.03), whereas it was not significant in "CellSearch" subgroup (HR, 1.15; 95% CI 0.45-2.92) and "other ICC" subgroup (HR, 1.09; 95% CI 0.62-1.90).The presence of CTC was also associated with an increased CA-125 (OR, 4.07; 95%CI, 1.87-8.85).

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

ABSTRACT

Background: The prognostic value of circulating tumor cells (CTCs) in ovarian cancer has been investigated in previous studies, but the results are controversial. Therefore we performed a meta-analysis to systematically review these data and evaluate the value of CTCs in ovarian cancer.

Materials and methods: A literary search for relevant studies was performed on Embase, Medline and Web of Science databases. Then pooled hazard ratios (HRs) for survival with 95% confidence intervals (CIs), subgroup analyses, sensitivity analyses, meta-regression analyses and publication bias were conducted.

Results: This meta-analysis is based on 11 publications and comprises a total of 1129 patients. The prognostic value of the CTC status was significant in overall survival (OS) (HR, 1.61;95% CI,1.22-2.13) and progression-free survival (PFS)/disease-free survival (DFS) (HR, 1.44; 95%CI, 1.18-1.75). Furthermore, subgroup analysis revealed that the value of CTC status in OS was significant in "RT-PCR" subgroup (HR, 2.02; 95% CI, 1.34-3.03), whereas it was not significant in "CellSearch" subgroup (HR, 1.15; 95% CI 0.45-2.92) and "other ICC" subgroup (HR, 1.09; 95% CI 0.62-1.90). The presence of CTC was also associated with an increased CA-125 (OR, 4.07; 95%CI, 1.87-8.85).

Conclusion: Our study demonstrates that CTC status is associated with OS and PFS/DFS in ovarian cancer.

No MeSH data available.


Related in: MedlinePlus

Forest plots of the association between CTCs and CA-125.CTCs = circulating tumor cells.
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pone.0130873.g006: Forest plots of the association between CTCs and CA-125.CTCs = circulating tumor cells.

Mentions: CA-125 is also a useful prognostic tumor marker for survival in ovarian cancer. Five studies reported data on correlation between the presence of CTC and elevated CA-125. Of these, one study [17] confirmed the correlation between CTC and CA-125. Conversely, four studies [18–20,22] suggested no correlation between CTC and CA-125. Pooled outcome from the five studies demonstrated a strong correlation between presence of CTC and increased CA-125 (OR, 4.07; 95%CI, 1.87–8.85; Fig 6).


Prognostic Value of Circulating Tumor Cells in Ovarian Cancer: A Meta-Analysis.

Zhou Y, Bian B, Yuan X, Xie G, Ma Y, Shen L - PLoS ONE (2015)

Forest plots of the association between CTCs and CA-125.CTCs = circulating tumor cells.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476582&req=5

pone.0130873.g006: Forest plots of the association between CTCs and CA-125.CTCs = circulating tumor cells.
Mentions: CA-125 is also a useful prognostic tumor marker for survival in ovarian cancer. Five studies reported data on correlation between the presence of CTC and elevated CA-125. Of these, one study [17] confirmed the correlation between CTC and CA-125. Conversely, four studies [18–20,22] suggested no correlation between CTC and CA-125. Pooled outcome from the five studies demonstrated a strong correlation between presence of CTC and increased CA-125 (OR, 4.07; 95%CI, 1.87–8.85; Fig 6).

Bottom Line: The prognostic value of the CTC status was significant in overall survival (OS) (HR, 1.61;95% CI,1.22-2.13) and progression-free survival (PFS)/disease-free survival (DFS) (HR, 1.44; 95%CI, 1.18-1.75).Furthermore, subgroup analysis revealed that the value of CTC status in OS was significant in "RT-PCR" subgroup (HR, 2.02; 95% CI, 1.34-3.03), whereas it was not significant in "CellSearch" subgroup (HR, 1.15; 95% CI 0.45-2.92) and "other ICC" subgroup (HR, 1.09; 95% CI 0.62-1.90).The presence of CTC was also associated with an increased CA-125 (OR, 4.07; 95%CI, 1.87-8.85).

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

ABSTRACT

Background: The prognostic value of circulating tumor cells (CTCs) in ovarian cancer has been investigated in previous studies, but the results are controversial. Therefore we performed a meta-analysis to systematically review these data and evaluate the value of CTCs in ovarian cancer.

Materials and methods: A literary search for relevant studies was performed on Embase, Medline and Web of Science databases. Then pooled hazard ratios (HRs) for survival with 95% confidence intervals (CIs), subgroup analyses, sensitivity analyses, meta-regression analyses and publication bias were conducted.

Results: This meta-analysis is based on 11 publications and comprises a total of 1129 patients. The prognostic value of the CTC status was significant in overall survival (OS) (HR, 1.61;95% CI,1.22-2.13) and progression-free survival (PFS)/disease-free survival (DFS) (HR, 1.44; 95%CI, 1.18-1.75). Furthermore, subgroup analysis revealed that the value of CTC status in OS was significant in "RT-PCR" subgroup (HR, 2.02; 95% CI, 1.34-3.03), whereas it was not significant in "CellSearch" subgroup (HR, 1.15; 95% CI 0.45-2.92) and "other ICC" subgroup (HR, 1.09; 95% CI 0.62-1.90). The presence of CTC was also associated with an increased CA-125 (OR, 4.07; 95%CI, 1.87-8.85).

Conclusion: Our study demonstrates that CTC status is associated with OS and PFS/DFS in ovarian cancer.

No MeSH data available.


Related in: MedlinePlus