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Prognostic Value of Circulating Tumor Cells in Ovarian Cancer: A Meta-Analysis.

Zhou Y, Bian B, Yuan X, Xie G, Ma Y, Shen L - PLoS ONE (2015)

Bottom Line: The prognostic value of the CTC status was significant in overall survival (OS) (HR, 1.61;95% CI,1.22-2.13) and progression-free survival (PFS)/disease-free survival (DFS) (HR, 1.44; 95%CI, 1.18-1.75).Furthermore, subgroup analysis revealed that the value of CTC status in OS was significant in "RT-PCR" subgroup (HR, 2.02; 95% CI, 1.34-3.03), whereas it was not significant in "CellSearch" subgroup (HR, 1.15; 95% CI 0.45-2.92) and "other ICC" subgroup (HR, 1.09; 95% CI 0.62-1.90).The presence of CTC was also associated with an increased CA-125 (OR, 4.07; 95%CI, 1.87-8.85).

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

ABSTRACT

Background: The prognostic value of circulating tumor cells (CTCs) in ovarian cancer has been investigated in previous studies, but the results are controversial. Therefore we performed a meta-analysis to systematically review these data and evaluate the value of CTCs in ovarian cancer.

Materials and methods: A literary search for relevant studies was performed on Embase, Medline and Web of Science databases. Then pooled hazard ratios (HRs) for survival with 95% confidence intervals (CIs), subgroup analyses, sensitivity analyses, meta-regression analyses and publication bias were conducted.

Results: This meta-analysis is based on 11 publications and comprises a total of 1129 patients. The prognostic value of the CTC status was significant in overall survival (OS) (HR, 1.61;95% CI,1.22-2.13) and progression-free survival (PFS)/disease-free survival (DFS) (HR, 1.44; 95%CI, 1.18-1.75). Furthermore, subgroup analysis revealed that the value of CTC status in OS was significant in "RT-PCR" subgroup (HR, 2.02; 95% CI, 1.34-3.03), whereas it was not significant in "CellSearch" subgroup (HR, 1.15; 95% CI 0.45-2.92) and "other ICC" subgroup (HR, 1.09; 95% CI 0.62-1.90). The presence of CTC was also associated with an increased CA-125 (OR, 4.07; 95%CI, 1.87-8.85).

Conclusion: Our study demonstrates that CTC status is associated with OS and PFS/DFS in ovarian cancer.

No MeSH data available.


Related in: MedlinePlus

PRISMA flow Chart of literature search and study selection.
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pone.0130873.g001: PRISMA flow Chart of literature search and study selection.

Mentions: The study followed the criterions for systematic review and meta-analysis of genetic association studies (S1 and S2 Checklists). The flowchart of search strategy for articles is presented in Fig 1 and S1 Table. 295 articles related to the keywords were initially reviewed. Of these articles, 280 were excluded after screening of titles, keywords and abstracts because they were obviously irrelevant studies, duplicates, reviews, abstracts and comments. Another 4 articles were excluded after reviewing the full texts because of insufficient data, multiple publications and small sample size, leaving 11 eligible studies [13–23]. published between 2002 and 2014. As shown in Table 1, a total of 1129 patients (ranging from 30 to 216 for individual study) were included in our meta-analysis. The detection rate of CTCs in these patients ranged from 12% to 83%. Most of studies were from Caucasian countries [13–16,18,20–23]. One study was from Asian countries [17] and the other one was from multi-country[19]. Methods used to detect CTCs were CellSearch system, other ICC and the RT-PCR. 64 women with cancer were included in Judson’s study [15], but only 51 patients with new diagnosis were included in the Kaplan–Meier distributions. 60 patients were enrolled in Behbakh’s study, whereas only 43 patients were included in the Kaplan–Meier PFS distributions for pre-treatment CTCs [14]. HRs with 95% CIs were directly extracted from original articles in three studies [17,19,23]. HRs with 95% CIs were not directly reported in eight studies [13–16,18,20–22] and calculated from Kaplan–Meier curves suggested by Tierney et al.[9]. Quality assessment of included studies is shown in Table 2.


Prognostic Value of Circulating Tumor Cells in Ovarian Cancer: A Meta-Analysis.

Zhou Y, Bian B, Yuan X, Xie G, Ma Y, Shen L - PLoS ONE (2015)

PRISMA flow Chart of literature search and study selection.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476582&req=5

pone.0130873.g001: PRISMA flow Chart of literature search and study selection.
Mentions: The study followed the criterions for systematic review and meta-analysis of genetic association studies (S1 and S2 Checklists). The flowchart of search strategy for articles is presented in Fig 1 and S1 Table. 295 articles related to the keywords were initially reviewed. Of these articles, 280 were excluded after screening of titles, keywords and abstracts because they were obviously irrelevant studies, duplicates, reviews, abstracts and comments. Another 4 articles were excluded after reviewing the full texts because of insufficient data, multiple publications and small sample size, leaving 11 eligible studies [13–23]. published between 2002 and 2014. As shown in Table 1, a total of 1129 patients (ranging from 30 to 216 for individual study) were included in our meta-analysis. The detection rate of CTCs in these patients ranged from 12% to 83%. Most of studies were from Caucasian countries [13–16,18,20–23]. One study was from Asian countries [17] and the other one was from multi-country[19]. Methods used to detect CTCs were CellSearch system, other ICC and the RT-PCR. 64 women with cancer were included in Judson’s study [15], but only 51 patients with new diagnosis were included in the Kaplan–Meier distributions. 60 patients were enrolled in Behbakh’s study, whereas only 43 patients were included in the Kaplan–Meier PFS distributions for pre-treatment CTCs [14]. HRs with 95% CIs were directly extracted from original articles in three studies [17,19,23]. HRs with 95% CIs were not directly reported in eight studies [13–16,18,20–22] and calculated from Kaplan–Meier curves suggested by Tierney et al.[9]. Quality assessment of included studies is shown in Table 2.

Bottom Line: The prognostic value of the CTC status was significant in overall survival (OS) (HR, 1.61;95% CI,1.22-2.13) and progression-free survival (PFS)/disease-free survival (DFS) (HR, 1.44; 95%CI, 1.18-1.75).Furthermore, subgroup analysis revealed that the value of CTC status in OS was significant in "RT-PCR" subgroup (HR, 2.02; 95% CI, 1.34-3.03), whereas it was not significant in "CellSearch" subgroup (HR, 1.15; 95% CI 0.45-2.92) and "other ICC" subgroup (HR, 1.09; 95% CI 0.62-1.90).The presence of CTC was also associated with an increased CA-125 (OR, 4.07; 95%CI, 1.87-8.85).

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

ABSTRACT

Background: The prognostic value of circulating tumor cells (CTCs) in ovarian cancer has been investigated in previous studies, but the results are controversial. Therefore we performed a meta-analysis to systematically review these data and evaluate the value of CTCs in ovarian cancer.

Materials and methods: A literary search for relevant studies was performed on Embase, Medline and Web of Science databases. Then pooled hazard ratios (HRs) for survival with 95% confidence intervals (CIs), subgroup analyses, sensitivity analyses, meta-regression analyses and publication bias were conducted.

Results: This meta-analysis is based on 11 publications and comprises a total of 1129 patients. The prognostic value of the CTC status was significant in overall survival (OS) (HR, 1.61;95% CI,1.22-2.13) and progression-free survival (PFS)/disease-free survival (DFS) (HR, 1.44; 95%CI, 1.18-1.75). Furthermore, subgroup analysis revealed that the value of CTC status in OS was significant in "RT-PCR" subgroup (HR, 2.02; 95% CI, 1.34-3.03), whereas it was not significant in "CellSearch" subgroup (HR, 1.15; 95% CI 0.45-2.92) and "other ICC" subgroup (HR, 1.09; 95% CI 0.62-1.90). The presence of CTC was also associated with an increased CA-125 (OR, 4.07; 95%CI, 1.87-8.85).

Conclusion: Our study demonstrates that CTC status is associated with OS and PFS/DFS in ovarian cancer.

No MeSH data available.


Related in: MedlinePlus