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Cardiovascular Risk Factors and Ethnicity Are Independent Factors Associated with Lower Urinary Tract Symptoms.

Lim J, Bhoo-Pathy N, Sothilingam S, Malek R, Sundram M, Tan GH, Bahadzor B, Ong TA, Ng KL, Abdul Razack AH - PLoS ONE (2015)

Bottom Line: There were 506 (50%) men found to have moderate-to-severe LUTS attaining an IPSS above 7.Considering individual lower urinary tract symptoms, we found a strong association of storage symptom with history of hypertension and hypercholesterolemia.Malay men were significantly bothered by post micturition symptom compared to their Chinese and Indian counterparts.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT

Objectives: To determine the lower urinary tract symptoms (LUTS) profile and factors affecting its degree of severity including cardiovascular risk profile, age, ethnicity, education level and prostate volume in a multiethnic Asian setting.

Materials and methods: We conducted a cross-sectional study of 1021 men aged 40-79 years with no clinical evidence of prostate cancer, prostate surgery or 5α-reductase inhibitor treatment of known prostate conditions. The severity of LUTS was assessed using the International Prostate Symptom Score (IPSS). Potential factors associated with LUTS including age, ethnicity, education, history of hypertension, diabetes and hypercholesterolemia, height, weight, and prostate volume were evaluated using univariable and multivariable analyses.

Results: There were 506 (50%) men found to have moderate-to-severe LUTS attaining an IPSS above 7. Overall, nocturia (45.5%) was the most frequently reported symptom. Multivariable analysis showed that age, ethnicity, prostate volume and history of hypertension and hypercholesterolemia were independent factors associated with severity of LUTS (p < 0.05). Considering individual lower urinary tract symptoms, we found a strong association of storage symptom with history of hypertension and hypercholesterolemia. Malay men were significantly bothered by post micturition symptom compared to their Chinese and Indian counterparts. Stratified analyses of LUTS demonstrated a mutually exclusive cardiovascular risk factors profile defined by ethnicity.

Conclusion: Severity of LUTS varies between different ethnicities across all age groups. In addition to age and prostate volume, ethnicity and cardiovascular risk factors including hypertension and hypercholesterolemia may also need to be taken into account in managing men with LUTS.

No MeSH data available.


Related in: MedlinePlus

Profile of storage, voiding and post micturition symptoms amongst various ethnicities.Venn diagram showing the distribution of urological symptoms in Malay (M), Chinese (C) and Indian (I) participants.
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pone.0130820.g001: Profile of storage, voiding and post micturition symptoms amongst various ethnicities.Venn diagram showing the distribution of urological symptoms in Malay (M), Chinese (C) and Indian (I) participants.

Mentions: Comparing LUTS in three clusters of urinary symptoms (Fig 1), storage scores were documented in approximately half of the individuals (489; 48%) and amongst these, 206 (42%) were bothered with both voiding and post micturition symptoms. Overall, 256 (25%) men had storage, voiding or post micturition symptoms only whilst combinations of these symptoms were observed in 413 (40%) subjects. For post micturition symptoms alone, nearly half of the Malay men (~ 53%) presented with the symptoms characterised by incomplete emptying (Fig 1). Chinese (44%) and Malays (43%) were more likely to have all three symptoms compared to their Indian counterparts (13%) (Fig 1).


Cardiovascular Risk Factors and Ethnicity Are Independent Factors Associated with Lower Urinary Tract Symptoms.

Lim J, Bhoo-Pathy N, Sothilingam S, Malek R, Sundram M, Tan GH, Bahadzor B, Ong TA, Ng KL, Abdul Razack AH - PLoS ONE (2015)

Profile of storage, voiding and post micturition symptoms amongst various ethnicities.Venn diagram showing the distribution of urological symptoms in Malay (M), Chinese (C) and Indian (I) participants.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4476577&req=5

pone.0130820.g001: Profile of storage, voiding and post micturition symptoms amongst various ethnicities.Venn diagram showing the distribution of urological symptoms in Malay (M), Chinese (C) and Indian (I) participants.
Mentions: Comparing LUTS in three clusters of urinary symptoms (Fig 1), storage scores were documented in approximately half of the individuals (489; 48%) and amongst these, 206 (42%) were bothered with both voiding and post micturition symptoms. Overall, 256 (25%) men had storage, voiding or post micturition symptoms only whilst combinations of these symptoms were observed in 413 (40%) subjects. For post micturition symptoms alone, nearly half of the Malay men (~ 53%) presented with the symptoms characterised by incomplete emptying (Fig 1). Chinese (44%) and Malays (43%) were more likely to have all three symptoms compared to their Indian counterparts (13%) (Fig 1).

Bottom Line: There were 506 (50%) men found to have moderate-to-severe LUTS attaining an IPSS above 7.Considering individual lower urinary tract symptoms, we found a strong association of storage symptom with history of hypertension and hypercholesterolemia.Malay men were significantly bothered by post micturition symptom compared to their Chinese and Indian counterparts.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT

Objectives: To determine the lower urinary tract symptoms (LUTS) profile and factors affecting its degree of severity including cardiovascular risk profile, age, ethnicity, education level and prostate volume in a multiethnic Asian setting.

Materials and methods: We conducted a cross-sectional study of 1021 men aged 40-79 years with no clinical evidence of prostate cancer, prostate surgery or 5α-reductase inhibitor treatment of known prostate conditions. The severity of LUTS was assessed using the International Prostate Symptom Score (IPSS). Potential factors associated with LUTS including age, ethnicity, education, history of hypertension, diabetes and hypercholesterolemia, height, weight, and prostate volume were evaluated using univariable and multivariable analyses.

Results: There were 506 (50%) men found to have moderate-to-severe LUTS attaining an IPSS above 7. Overall, nocturia (45.5%) was the most frequently reported symptom. Multivariable analysis showed that age, ethnicity, prostate volume and history of hypertension and hypercholesterolemia were independent factors associated with severity of LUTS (p < 0.05). Considering individual lower urinary tract symptoms, we found a strong association of storage symptom with history of hypertension and hypercholesterolemia. Malay men were significantly bothered by post micturition symptom compared to their Chinese and Indian counterparts. Stratified analyses of LUTS demonstrated a mutually exclusive cardiovascular risk factors profile defined by ethnicity.

Conclusion: Severity of LUTS varies between different ethnicities across all age groups. In addition to age and prostate volume, ethnicity and cardiovascular risk factors including hypertension and hypercholesterolemia may also need to be taken into account in managing men with LUTS.

No MeSH data available.


Related in: MedlinePlus