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Large pseudoangiomatous stromal hyperplasia complicated with gynecomastia and lobular differentiation in a male breast.

Mizutou A, Nakashima K, Moriya T - Springerplus (2015)

Bottom Line: Pseudoangiomatous stromal hyperplasia (PASH) is a benign lesion often observed in parts of the mammary stroma in a variety of breast diseases.It is characterized by stromal myofibroblastic proliferation that possesses irregularly anastomosing slit-like pseudovascular spaces lined by a layer of spindle cells.It was complicated by gynecomastia with acinar and lobular formation, which resembled female mammary gland secretory activity that is observed during lactation.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Kawasaki Medical School, 2-1-80 Nakasange, Kita-ku, Okayama, 700-8505 Japan.

ABSTRACT
Pseudoangiomatous stromal hyperplasia (PASH) is a benign lesion often observed in parts of the mammary stroma in a variety of breast diseases. It is characterized by stromal myofibroblastic proliferation that possesses irregularly anastomosing slit-like pseudovascular spaces lined by a layer of spindle cells. PASH commonly occurs in premenopausal women; however, it has also been observed in men with gynecomastia. Although tumor-forming lesions are rare, we report on a case with a large PASH in a male breast complicated with gynecomastia. Imaging showed a tumor with a diameter of >10 cm in the left breast, and aspiration cytology revealed a benign lesion. Since the tumor was large and gradually increased in size, a simple mastectomy was performed. The tumorous lesion was diagnosed as PASH based on the pathological and immunohistological findings. It was complicated by gynecomastia with acinar and lobular formation, which resembled female mammary gland secretory activity that is observed during lactation.

No MeSH data available.


Related in: MedlinePlus

The tumor is well-defined, solid, and lobular with grayish-white cross sections.
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Fig3: The tumor is well-defined, solid, and lobular with grayish-white cross sections.

Mentions: The tumor of the left breast was well-defined, solid, and lobular with grayish-white cross sections (Figure 3). Pathologically, there was collagenous stromal proliferation intermixed with lobular and ductal elements. The stroma was dense and contained a pseudoangiomatous structure with irregularly anastomosing slit-like spaces. These slit-like spaces were lined by spindle-shaped cells, which presented with mild nuclear hypertrophy, but there was no nuclear division or atypia (Figure 4a, b).Figure 3


Large pseudoangiomatous stromal hyperplasia complicated with gynecomastia and lobular differentiation in a male breast.

Mizutou A, Nakashima K, Moriya T - Springerplus (2015)

The tumor is well-defined, solid, and lobular with grayish-white cross sections.
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4472651&req=5

Fig3: The tumor is well-defined, solid, and lobular with grayish-white cross sections.
Mentions: The tumor of the left breast was well-defined, solid, and lobular with grayish-white cross sections (Figure 3). Pathologically, there was collagenous stromal proliferation intermixed with lobular and ductal elements. The stroma was dense and contained a pseudoangiomatous structure with irregularly anastomosing slit-like spaces. These slit-like spaces were lined by spindle-shaped cells, which presented with mild nuclear hypertrophy, but there was no nuclear division or atypia (Figure 4a, b).Figure 3

Bottom Line: Pseudoangiomatous stromal hyperplasia (PASH) is a benign lesion often observed in parts of the mammary stroma in a variety of breast diseases.It is characterized by stromal myofibroblastic proliferation that possesses irregularly anastomosing slit-like pseudovascular spaces lined by a layer of spindle cells.It was complicated by gynecomastia with acinar and lobular formation, which resembled female mammary gland secretory activity that is observed during lactation.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Kawasaki Medical School, 2-1-80 Nakasange, Kita-ku, Okayama, 700-8505 Japan.

ABSTRACT
Pseudoangiomatous stromal hyperplasia (PASH) is a benign lesion often observed in parts of the mammary stroma in a variety of breast diseases. It is characterized by stromal myofibroblastic proliferation that possesses irregularly anastomosing slit-like pseudovascular spaces lined by a layer of spindle cells. PASH commonly occurs in premenopausal women; however, it has also been observed in men with gynecomastia. Although tumor-forming lesions are rare, we report on a case with a large PASH in a male breast complicated with gynecomastia. Imaging showed a tumor with a diameter of >10 cm in the left breast, and aspiration cytology revealed a benign lesion. Since the tumor was large and gradually increased in size, a simple mastectomy was performed. The tumorous lesion was diagnosed as PASH based on the pathological and immunohistological findings. It was complicated by gynecomastia with acinar and lobular formation, which resembled female mammary gland secretory activity that is observed during lactation.

No MeSH data available.


Related in: MedlinePlus