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Association of insulin resistance and coronary artery remodeling: an intravascular ultrasound study.

Kim SH, Moon JY, Lim YM, Kim KH, Yang WI, Sung JH, Yoo SM, Kim IJ, Lim SW, Cha DH, Cho SY - Cardiovasc Diabetol (2015)

Bottom Line: Remodeling index was significantly higher in the HOMA-IR positive group compared with the negative group (HOMA-IR positive vs. negative: 1.074 ± 0.109 vs. 1.042 ± 0.131, p = 0.013).There was a significant positive correlation between remodeling index and HOMA-IR (p = 0.010).Increased IR estimated by HOMA-IR was significantly associated with a higher remodeling index and positive coronary artery remodeling.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.

ABSTRACT

Background: There are few studies that investigated the correlation between insulin resistance (IR) and the coronary artery remodeling. The aim of the study is to investigate the association of IR measured by homeostasis model assessment of insulin resistance (HOMA-IR) and coronary artery remodeling evaluated by intravascular ultrasound (IVUS).

Methods: A total of 298 consecutive patients who received percutaneous coronary interventions under IVUS guidance were retrospectively enrolled. The value of HOMA-IR more than 2.5 was considered as IR positive. Metabolic syndrome was classified according to NCEP ATP III guidelines. The remodeling index was defined as the ratio of the external elastic membrane (EEM) area at the lesion site to the EEM area at the proximal reference site.

Results: A total of 369 lesions were analyzed (161 lesions in HOMA-IR positive and 208 lesions in HOMA-IR negative). Remodeling index was significantly higher in the HOMA-IR positive group compared with the negative group (HOMA-IR positive vs. negative: 1.074 ± 0.109 vs. 1.042 ± 0.131, p = 0.013). There was a significant positive correlation between remodeling index and HOMA-IR (p = 0.010). Analysis of HOMA-IR according to remodeling groups showed increasing tendency of HOMA-IR, and it was statistically significant (p = 0.045). Multivariate analysis revealed that only HOMA-IR was an independent predictor of remodeling index (r = 0.166, p = 0.018).

Conclusion: Increased IR estimated by HOMA-IR was significantly associated with a higher remodeling index and positive coronary artery remodeling.

No MeSH data available.


Related in: MedlinePlus

Example case of patient with insulin resistance. Seventy six year-old man who received PCI due to ST elevation myocardial infarction. The positive remodeling of proximal right coronary artery was demonstrated. The remodeling index was 1.373 which was calculated by lesion EEM (arrow b, panel b, 24.3 mm2) divided by reference EEM (arrow a, panel a, 17.7 mm2)
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Fig1: Example case of patient with insulin resistance. Seventy six year-old man who received PCI due to ST elevation myocardial infarction. The positive remodeling of proximal right coronary artery was demonstrated. The remodeling index was 1.373 which was calculated by lesion EEM (arrow b, panel b, 24.3 mm2) divided by reference EEM (arrow a, panel a, 17.7 mm2)

Mentions: Coronary artery remodeling was defined by comparing the EEM area at the lesion site to the EEM area at the proximal reference site. The remodeling index was defined as the ratio of the EEM area at the lesion site to the EEM area at the proximal reference site in this study (Fig. 1). Patterns of arterial remodeling were classified into three categories; positive remodeling was defined as a remodeling index >1.05; intermediate remodeling as a remodeling index between 0.95 and 1.05; negative remodeling as a remodeling index <0.95 [3, 14].Fig. 1


Association of insulin resistance and coronary artery remodeling: an intravascular ultrasound study.

Kim SH, Moon JY, Lim YM, Kim KH, Yang WI, Sung JH, Yoo SM, Kim IJ, Lim SW, Cha DH, Cho SY - Cardiovasc Diabetol (2015)

Example case of patient with insulin resistance. Seventy six year-old man who received PCI due to ST elevation myocardial infarction. The positive remodeling of proximal right coronary artery was demonstrated. The remodeling index was 1.373 which was calculated by lesion EEM (arrow b, panel b, 24.3 mm2) divided by reference EEM (arrow a, panel a, 17.7 mm2)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4472609&req=5

Fig1: Example case of patient with insulin resistance. Seventy six year-old man who received PCI due to ST elevation myocardial infarction. The positive remodeling of proximal right coronary artery was demonstrated. The remodeling index was 1.373 which was calculated by lesion EEM (arrow b, panel b, 24.3 mm2) divided by reference EEM (arrow a, panel a, 17.7 mm2)
Mentions: Coronary artery remodeling was defined by comparing the EEM area at the lesion site to the EEM area at the proximal reference site. The remodeling index was defined as the ratio of the EEM area at the lesion site to the EEM area at the proximal reference site in this study (Fig. 1). Patterns of arterial remodeling were classified into three categories; positive remodeling was defined as a remodeling index >1.05; intermediate remodeling as a remodeling index between 0.95 and 1.05; negative remodeling as a remodeling index <0.95 [3, 14].Fig. 1

Bottom Line: Remodeling index was significantly higher in the HOMA-IR positive group compared with the negative group (HOMA-IR positive vs. negative: 1.074 ± 0.109 vs. 1.042 ± 0.131, p = 0.013).There was a significant positive correlation between remodeling index and HOMA-IR (p = 0.010).Increased IR estimated by HOMA-IR was significantly associated with a higher remodeling index and positive coronary artery remodeling.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.

ABSTRACT

Background: There are few studies that investigated the correlation between insulin resistance (IR) and the coronary artery remodeling. The aim of the study is to investigate the association of IR measured by homeostasis model assessment of insulin resistance (HOMA-IR) and coronary artery remodeling evaluated by intravascular ultrasound (IVUS).

Methods: A total of 298 consecutive patients who received percutaneous coronary interventions under IVUS guidance were retrospectively enrolled. The value of HOMA-IR more than 2.5 was considered as IR positive. Metabolic syndrome was classified according to NCEP ATP III guidelines. The remodeling index was defined as the ratio of the external elastic membrane (EEM) area at the lesion site to the EEM area at the proximal reference site.

Results: A total of 369 lesions were analyzed (161 lesions in HOMA-IR positive and 208 lesions in HOMA-IR negative). Remodeling index was significantly higher in the HOMA-IR positive group compared with the negative group (HOMA-IR positive vs. negative: 1.074 ± 0.109 vs. 1.042 ± 0.131, p = 0.013). There was a significant positive correlation between remodeling index and HOMA-IR (p = 0.010). Analysis of HOMA-IR according to remodeling groups showed increasing tendency of HOMA-IR, and it was statistically significant (p = 0.045). Multivariate analysis revealed that only HOMA-IR was an independent predictor of remodeling index (r = 0.166, p = 0.018).

Conclusion: Increased IR estimated by HOMA-IR was significantly associated with a higher remodeling index and positive coronary artery remodeling.

No MeSH data available.


Related in: MedlinePlus