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Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies.

Waitt CJ, Garner P, Bonnett LJ, Khoo SH, Else LJ - J. Antimicrob. Chemother. (2015)

Bottom Line: There was substantial variability in the clinical and laboratory methods used and in reported results.Transfer to untreated infants appears quantitatively important for some NRTIs and NNRTIs.The pharmacokinetic methods varied widely and we propose standards for the design, analysis and reporting of future pharmacokinetic studies of drug transfer during breastfeeding.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular and Clinical Pharmacology, University of Liverpool, Block A, The Waterhouse Buildings, 1-5 Brownlow Street, Liverpool L69 3GE, UK cwaitt@liv.ac.uk.

No MeSH data available.


Related in: MedlinePlus

‘Dose’ via BM to a fully breast-fed 3 kg infant, as a percentage of recommended paediatric dose. Pooled statistics are shown by the diamond and the I2 statistic is indicated. EFV, efavirenz; NVP, nevirapine; 3TC, lamivudine; d4T, stavudine; ZDV, zidovudine; LPV, lopinavir; RTV, ritonavir; NaN, not a number. *Conference proceeding.
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DKV080F6: ‘Dose’ via BM to a fully breast-fed 3 kg infant, as a percentage of recommended paediatric dose. Pooled statistics are shown by the diamond and the I2 statistic is indicated. EFV, efavirenz; NVP, nevirapine; 3TC, lamivudine; d4T, stavudine; ZDV, zidovudine; LPV, lopinavir; RTV, ritonavir; NaN, not a number. *Conference proceeding.

Mentions: The ARV concentrations in MP and BM and the corresponding BM : MP ratios for each class of drug are summarized in Figures 2–4. Data on infant ARV concentrations resulting from BM exposure are summarized in Figure 5. Figure 6 illustrates the percentage of recommended infant dose ingested by a fully breast-fed 3 kg infant; results for other weights were similar and are not presented here.Figure 2.


Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies.

Waitt CJ, Garner P, Bonnett LJ, Khoo SH, Else LJ - J. Antimicrob. Chemother. (2015)

‘Dose’ via BM to a fully breast-fed 3 kg infant, as a percentage of recommended paediatric dose. Pooled statistics are shown by the diamond and the I2 statistic is indicated. EFV, efavirenz; NVP, nevirapine; 3TC, lamivudine; d4T, stavudine; ZDV, zidovudine; LPV, lopinavir; RTV, ritonavir; NaN, not a number. *Conference proceeding.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4472329&req=5

DKV080F6: ‘Dose’ via BM to a fully breast-fed 3 kg infant, as a percentage of recommended paediatric dose. Pooled statistics are shown by the diamond and the I2 statistic is indicated. EFV, efavirenz; NVP, nevirapine; 3TC, lamivudine; d4T, stavudine; ZDV, zidovudine; LPV, lopinavir; RTV, ritonavir; NaN, not a number. *Conference proceeding.
Mentions: The ARV concentrations in MP and BM and the corresponding BM : MP ratios for each class of drug are summarized in Figures 2–4. Data on infant ARV concentrations resulting from BM exposure are summarized in Figure 5. Figure 6 illustrates the percentage of recommended infant dose ingested by a fully breast-fed 3 kg infant; results for other weights were similar and are not presented here.Figure 2.

Bottom Line: There was substantial variability in the clinical and laboratory methods used and in reported results.Transfer to untreated infants appears quantitatively important for some NRTIs and NNRTIs.The pharmacokinetic methods varied widely and we propose standards for the design, analysis and reporting of future pharmacokinetic studies of drug transfer during breastfeeding.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular and Clinical Pharmacology, University of Liverpool, Block A, The Waterhouse Buildings, 1-5 Brownlow Street, Liverpool L69 3GE, UK cwaitt@liv.ac.uk.

No MeSH data available.


Related in: MedlinePlus