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Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies.

Waitt CJ, Garner P, Bonnett LJ, Khoo SH, Else LJ - J. Antimicrob. Chemother. (2015)

Bottom Line: There was substantial variability in the clinical and laboratory methods used and in reported results.Transfer to untreated infants appears quantitatively important for some NRTIs and NNRTIs.The pharmacokinetic methods varied widely and we propose standards for the design, analysis and reporting of future pharmacokinetic studies of drug transfer during breastfeeding.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular and Clinical Pharmacology, University of Liverpool, Block A, The Waterhouse Buildings, 1-5 Brownlow Street, Liverpool L69 3GE, UK cwaitt@liv.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Forest plot of IP : BM ratios for all drugs where infant concentrations were detectable, grouped according to drug class. Where studies reported drug levels at different infant ages, these are represented as a separate line. Pooled statistics are shown by the diamond and the I2 statistic is indicated. EFV, efavirenz; NVP, nevirapine; 3TC, lamivudine; ZDV, zidovudine; LPV, lopinavir; RTV, ritonavir; NR, not reported; NA, not available. *Conference proceeding.
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DKV080F5: Forest plot of IP : BM ratios for all drugs where infant concentrations were detectable, grouped according to drug class. Where studies reported drug levels at different infant ages, these are represented as a separate line. Pooled statistics are shown by the diamond and the I2 statistic is indicated. EFV, efavirenz; NVP, nevirapine; 3TC, lamivudine; ZDV, zidovudine; LPV, lopinavir; RTV, ritonavir; NR, not reported; NA, not available. *Conference proceeding.

Mentions: The ARV concentrations in MP and BM and the corresponding BM : MP ratios for each class of drug are summarized in Figures 2–4. Data on infant ARV concentrations resulting from BM exposure are summarized in Figure 5. Figure 6 illustrates the percentage of recommended infant dose ingested by a fully breast-fed 3 kg infant; results for other weights were similar and are not presented here.Figure 2.


Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies.

Waitt CJ, Garner P, Bonnett LJ, Khoo SH, Else LJ - J. Antimicrob. Chemother. (2015)

Forest plot of IP : BM ratios for all drugs where infant concentrations were detectable, grouped according to drug class. Where studies reported drug levels at different infant ages, these are represented as a separate line. Pooled statistics are shown by the diamond and the I2 statistic is indicated. EFV, efavirenz; NVP, nevirapine; 3TC, lamivudine; ZDV, zidovudine; LPV, lopinavir; RTV, ritonavir; NR, not reported; NA, not available. *Conference proceeding.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4472329&req=5

DKV080F5: Forest plot of IP : BM ratios for all drugs where infant concentrations were detectable, grouped according to drug class. Where studies reported drug levels at different infant ages, these are represented as a separate line. Pooled statistics are shown by the diamond and the I2 statistic is indicated. EFV, efavirenz; NVP, nevirapine; 3TC, lamivudine; ZDV, zidovudine; LPV, lopinavir; RTV, ritonavir; NR, not reported; NA, not available. *Conference proceeding.
Mentions: The ARV concentrations in MP and BM and the corresponding BM : MP ratios for each class of drug are summarized in Figures 2–4. Data on infant ARV concentrations resulting from BM exposure are summarized in Figure 5. Figure 6 illustrates the percentage of recommended infant dose ingested by a fully breast-fed 3 kg infant; results for other weights were similar and are not presented here.Figure 2.

Bottom Line: There was substantial variability in the clinical and laboratory methods used and in reported results.Transfer to untreated infants appears quantitatively important for some NRTIs and NNRTIs.The pharmacokinetic methods varied widely and we propose standards for the design, analysis and reporting of future pharmacokinetic studies of drug transfer during breastfeeding.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular and Clinical Pharmacology, University of Liverpool, Block A, The Waterhouse Buildings, 1-5 Brownlow Street, Liverpool L69 3GE, UK cwaitt@liv.ac.uk.

No MeSH data available.


Related in: MedlinePlus