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Quality and Quantity of Published Studies Evaluating Lumbar Fusion during the Past 10 Years: A Systematic Review.

Hart R, Hermsmeyer JT, Sethi RK, Norvell DC - Global Spine J (2015)

Bottom Line: (4) Is there a difference in the type and quality of adverse events measures reported among RCTs over time?Results Forty-two RCTs between January 1, 2004, and December 31, 2013, met the inclusion criteria and form the basis for this report.No RCTs were identified evaluating patients with deformity or adjacent segment disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedics, Oregon Health and Science University, Portland, Oregon, United States.

ABSTRACT
Study Design Systematic review. Clinical Questions (1) Has the proportion and number of randomized controlled trials (RCTs) as an indicator of quality of evidence regarding lumbar fusion increased over the past 10 years? (2) Is there a difference in the proportion of RCTs among the four primary fusion diagnoses (degenerative disk disease, spondylolisthesis, deformity, and adjacent segment disease) over the past 10 years? (3) Is there a difference in the type and quality of clinical outcomes measures reported among RCTs over time? (4) Is there a difference in the type and quality of adverse events measures reported among RCTs over time? (5) Are there changes in fusion surgical approach and techniques over time by diagnosis over the past 10 years? Methods Electronic databases and reference lists of key articles were searched from January 1, 2004, through December 31, 2013, to identify lumbar fusion RCTs. Fusion studies designed specifically to evaluate recombinant human bone morphogenetic protein-2 or other bone substitutes, revision surgery studies, nonrandomized comparison studies, case reports, case series, and cost-effectiveness studies were excluded. Results Forty-two RCTs between January 1, 2004, and December 31, 2013, met the inclusion criteria and form the basis for this report. There were 35 RCTs identified evaluating patients diagnosed with degenerative disk disease, 4 RCTs evaluating patients diagnosed with degenerative spondylolisthesis, and 3 RCTs evaluating patients with a combination of degenerative disk disease and degenerative spondylolisthesis. No RCTs were identified evaluating patients with deformity or adjacent segment disease. Conclusions This structured review demonstrates that there has been an increase in the available clinical database of RCTs using patient-reported outcomes evaluating the benefit of lumbar spinal fusion for the diagnoses of degenerative disk disease and degenerative spondylolisthesis. Gaps remain in the standardization of reportage of adverse events in such trials, as well as uniformity of surgical approaches used. Finally, continued efforts to develop higher-quality data for other surgical indications for lumbar fusion, most notably in the presence of adult spinal deformity and revision of prior surgical fusions, appear warranted.

No MeSH data available.


Related in: MedlinePlus

Percentage of included randomized controlled trials (RCTs) measuring Oswestry Disability Index (ODI), visual analog scale (VAS), and Short-Form 36 (SF-36).
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FI1500008sr-4: Percentage of included randomized controlled trials (RCTs) measuring Oswestry Disability Index (ODI), visual analog scale (VAS), and Short-Form 36 (SF-36).

Mentions: The difference in the proportion of RCTs among the four primary fusion diagnoses (DDD, DS, ASD, AD) over the past 10 years. Abbreviations: AD, adult deformity; ASD, adjacent segment disease; DDD, degenerative disk disease; DS, degenerative spondylolisthesis; RCT, randomized controlled trail. *No RCT found evaluating ASD or AD.


Quality and Quantity of Published Studies Evaluating Lumbar Fusion during the Past 10 Years: A Systematic Review.

Hart R, Hermsmeyer JT, Sethi RK, Norvell DC - Global Spine J (2015)

Percentage of included randomized controlled trials (RCTs) measuring Oswestry Disability Index (ODI), visual analog scale (VAS), and Short-Form 36 (SF-36).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4472285&req=5

FI1500008sr-4: Percentage of included randomized controlled trials (RCTs) measuring Oswestry Disability Index (ODI), visual analog scale (VAS), and Short-Form 36 (SF-36).
Mentions: The difference in the proportion of RCTs among the four primary fusion diagnoses (DDD, DS, ASD, AD) over the past 10 years. Abbreviations: AD, adult deformity; ASD, adjacent segment disease; DDD, degenerative disk disease; DS, degenerative spondylolisthesis; RCT, randomized controlled trail. *No RCT found evaluating ASD or AD.

Bottom Line: (4) Is there a difference in the type and quality of adverse events measures reported among RCTs over time?Results Forty-two RCTs between January 1, 2004, and December 31, 2013, met the inclusion criteria and form the basis for this report.No RCTs were identified evaluating patients with deformity or adjacent segment disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedics, Oregon Health and Science University, Portland, Oregon, United States.

ABSTRACT
Study Design Systematic review. Clinical Questions (1) Has the proportion and number of randomized controlled trials (RCTs) as an indicator of quality of evidence regarding lumbar fusion increased over the past 10 years? (2) Is there a difference in the proportion of RCTs among the four primary fusion diagnoses (degenerative disk disease, spondylolisthesis, deformity, and adjacent segment disease) over the past 10 years? (3) Is there a difference in the type and quality of clinical outcomes measures reported among RCTs over time? (4) Is there a difference in the type and quality of adverse events measures reported among RCTs over time? (5) Are there changes in fusion surgical approach and techniques over time by diagnosis over the past 10 years? Methods Electronic databases and reference lists of key articles were searched from January 1, 2004, through December 31, 2013, to identify lumbar fusion RCTs. Fusion studies designed specifically to evaluate recombinant human bone morphogenetic protein-2 or other bone substitutes, revision surgery studies, nonrandomized comparison studies, case reports, case series, and cost-effectiveness studies were excluded. Results Forty-two RCTs between January 1, 2004, and December 31, 2013, met the inclusion criteria and form the basis for this report. There were 35 RCTs identified evaluating patients diagnosed with degenerative disk disease, 4 RCTs evaluating patients diagnosed with degenerative spondylolisthesis, and 3 RCTs evaluating patients with a combination of degenerative disk disease and degenerative spondylolisthesis. No RCTs were identified evaluating patients with deformity or adjacent segment disease. Conclusions This structured review demonstrates that there has been an increase in the available clinical database of RCTs using patient-reported outcomes evaluating the benefit of lumbar spinal fusion for the diagnoses of degenerative disk disease and degenerative spondylolisthesis. Gaps remain in the standardization of reportage of adverse events in such trials, as well as uniformity of surgical approaches used. Finally, continued efforts to develop higher-quality data for other surgical indications for lumbar fusion, most notably in the presence of adult spinal deformity and revision of prior surgical fusions, appear warranted.

No MeSH data available.


Related in: MedlinePlus