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A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study.

Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K - Cancer Med (2015)

Bottom Line: Three patients did not undergo surgery because of progressive disease (PD) and 13 refused.However, a patient with CRPD was in the higher total accumulated thermal output group.Using these parameters, the exact output, optimal thermal treatment, and contraindications or indications of this modality could be determined in a multi-institutional, future study.

View Article: PubMed Central - PubMed

Affiliation: Division of Surgery, Hidaka Hospital, Gunma, Japan.

No MeSH data available.


Related in: MedlinePlus

Changes in possible body temperature during 50 min irradiation according to the correlation between total accumulated thermal output (TATO) (A: 549, B: 429–548, C: 428) and objective response. In patients with 429–548 TATO, patients with pathological complete response (ypCR) showed significant increase in temperature (B), but there was no increase in those with 428 or lower TATO (C). Data in the figure are presented as means with standard error (SEM).
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fig06: Changes in possible body temperature during 50 min irradiation according to the correlation between total accumulated thermal output (TATO) (A: 549, B: 429–548, C: 428) and objective response. In patients with 429–548 TATO, patients with pathological complete response (ypCR) showed significant increase in temperature (B), but there was no increase in those with 428 or lower TATO (C). Data in the figure are presented as means with standard error (SEM).

Mentions: Figure 6 shows changes in body temperature during 50 min irradiation according to the correlation between TATO (Fig. 6A: 549, Fig. 6B: 429–548, Fig. 6C: 428) and objective response. In patients in whom body temperature increased, consequently had a good outcome (Fig. 6B), and patients in whom body temperature did not increase, still had a good outcome from this modality (Fig. 6C).


A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study.

Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K - Cancer Med (2015)

Changes in possible body temperature during 50 min irradiation according to the correlation between total accumulated thermal output (TATO) (A: 549, B: 429–548, C: 428) and objective response. In patients with 429–548 TATO, patients with pathological complete response (ypCR) showed significant increase in temperature (B), but there was no increase in those with 428 or lower TATO (C). Data in the figure are presented as means with standard error (SEM).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4472206&req=5

fig06: Changes in possible body temperature during 50 min irradiation according to the correlation between total accumulated thermal output (TATO) (A: 549, B: 429–548, C: 428) and objective response. In patients with 429–548 TATO, patients with pathological complete response (ypCR) showed significant increase in temperature (B), but there was no increase in those with 428 or lower TATO (C). Data in the figure are presented as means with standard error (SEM).
Mentions: Figure 6 shows changes in body temperature during 50 min irradiation according to the correlation between TATO (Fig. 6A: 549, Fig. 6B: 429–548, Fig. 6C: 428) and objective response. In patients in whom body temperature increased, consequently had a good outcome (Fig. 6B), and patients in whom body temperature did not increase, still had a good outcome from this modality (Fig. 6C).

Bottom Line: Three patients did not undergo surgery because of progressive disease (PD) and 13 refused.However, a patient with CRPD was in the higher total accumulated thermal output group.Using these parameters, the exact output, optimal thermal treatment, and contraindications or indications of this modality could be determined in a multi-institutional, future study.

View Article: PubMed Central - PubMed

Affiliation: Division of Surgery, Hidaka Hospital, Gunma, Japan.

No MeSH data available.


Related in: MedlinePlus