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A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study.

Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K - Cancer Med (2015)

Bottom Line: Three patients did not undergo surgery because of progressive disease (PD) and 13 refused.However, a patient with CRPD was in the higher total accumulated thermal output group.Using these parameters, the exact output, optimal thermal treatment, and contraindications or indications of this modality could be determined in a multi-institutional, future study.

View Article: PubMed Central - PubMed

Affiliation: Division of Surgery, Hidaka Hospital, Gunma, Japan.

No MeSH data available.


Related in: MedlinePlus

Correlation among objective response, total accumulated irradiation output (TAIO) and total accumulated thermal output (TATO) in 35 patients. In patients with 6.2 or lower TAIO, local complete response with distant progressive disease (CRPD), grade 2, 1b progressive disease (PD), and PD were seen, while in those with 10.44 or lower TAIO, one CRPD patient was present in those with 549 or higher TATO. PR, partial response; SD, stable disease.
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fig04: Correlation among objective response, total accumulated irradiation output (TAIO) and total accumulated thermal output (TATO) in 35 patients. In patients with 6.2 or lower TAIO, local complete response with distant progressive disease (CRPD), grade 2, 1b progressive disease (PD), and PD were seen, while in those with 10.44 or lower TAIO, one CRPD patient was present in those with 549 or higher TATO. PR, partial response; SD, stable disease.

Mentions: Figure 4 shows the correlation among objective response, TAIO and TATO in 35 patients. Consequently, ypCR patients were present in the middle TAIO and TATO group, while PD patients in lowest TAIO group. In 6.2 or lower TAIO and 429 or higher TATO, ypCR plus CR was shown in only one case, while 10 (27.0%) in 6.21 or higher TAIO, and also 9 (90%) patients of total 10 ypCR plus CR patients were shown in patients with 6.21 or higher TAIO and 429 or higher TATO. From these data, we think that 6.21 or higher TAIO and 429 or higher TATO are proper output and thermal dose.


A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study.

Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K - Cancer Med (2015)

Correlation among objective response, total accumulated irradiation output (TAIO) and total accumulated thermal output (TATO) in 35 patients. In patients with 6.2 or lower TAIO, local complete response with distant progressive disease (CRPD), grade 2, 1b progressive disease (PD), and PD were seen, while in those with 10.44 or lower TAIO, one CRPD patient was present in those with 549 or higher TATO. PR, partial response; SD, stable disease.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4472206&req=5

fig04: Correlation among objective response, total accumulated irradiation output (TAIO) and total accumulated thermal output (TATO) in 35 patients. In patients with 6.2 or lower TAIO, local complete response with distant progressive disease (CRPD), grade 2, 1b progressive disease (PD), and PD were seen, while in those with 10.44 or lower TAIO, one CRPD patient was present in those with 549 or higher TATO. PR, partial response; SD, stable disease.
Mentions: Figure 4 shows the correlation among objective response, TAIO and TATO in 35 patients. Consequently, ypCR patients were present in the middle TAIO and TATO group, while PD patients in lowest TAIO group. In 6.2 or lower TAIO and 429 or higher TATO, ypCR plus CR was shown in only one case, while 10 (27.0%) in 6.21 or higher TAIO, and also 9 (90%) patients of total 10 ypCR plus CR patients were shown in patients with 6.21 or higher TAIO and 429 or higher TATO. From these data, we think that 6.21 or higher TAIO and 429 or higher TATO are proper output and thermal dose.

Bottom Line: Three patients did not undergo surgery because of progressive disease (PD) and 13 refused.However, a patient with CRPD was in the higher total accumulated thermal output group.Using these parameters, the exact output, optimal thermal treatment, and contraindications or indications of this modality could be determined in a multi-institutional, future study.

View Article: PubMed Central - PubMed

Affiliation: Division of Surgery, Hidaka Hospital, Gunma, Japan.

No MeSH data available.


Related in: MedlinePlus