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A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study.

Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K - Cancer Med (2015)

Bottom Line: Three patients did not undergo surgery because of progressive disease (PD) and 13 refused.However, a patient with CRPD was in the higher total accumulated thermal output group.Using these parameters, the exact output, optimal thermal treatment, and contraindications or indications of this modality could be determined in a multi-institutional, future study.

View Article: PubMed Central - PubMed

Affiliation: Division of Surgery, Hidaka Hospital, Gunma, Japan.

No MeSH data available.


Related in: MedlinePlus

Protocol of this study. CT, computed tomography; MRI, magnetic resonance imaging; PET/CT, positron emission tomography/computed tomography; IMRT, intensity-modulated radiation therapy.
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fig01: Protocol of this study. CT, computed tomography; MRI, magnetic resonance imaging; PET/CT, positron emission tomography/computed tomography; IMRT, intensity-modulated radiation therapy.

Mentions: A sensor catheter with four temperature points was placed in the rectum in 12 patients while it was attached to the skin on the lateral abdominal side in 30 patients who received standardized therapy and in seven who did not. The accumulated surface skin thermal output of four temperature points was calculated from the estimated internal temperature of patients during the 50 min of each irradiation. An increased thermometry scale of the skin was added to the pretreatment axillar temperature of the patients to obtain a hypothetical internal body temperature that may be the possible core temperature. TATO was considered the heat effect of each treatment. Both temperature and output curves were recorded at 1-min intervals from 1 to 50 min. Body surface area was calculated by the DuBois formula (BSA = W0.425 × H0.725 × 0.007184) 10. Figure 1 summarizes the protocol of this study. All patients received the same CRT and hyperthermic therapy with or without neothermia.


A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study.

Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K - Cancer Med (2015)

Protocol of this study. CT, computed tomography; MRI, magnetic resonance imaging; PET/CT, positron emission tomography/computed tomography; IMRT, intensity-modulated radiation therapy.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4472206&req=5

fig01: Protocol of this study. CT, computed tomography; MRI, magnetic resonance imaging; PET/CT, positron emission tomography/computed tomography; IMRT, intensity-modulated radiation therapy.
Mentions: A sensor catheter with four temperature points was placed in the rectum in 12 patients while it was attached to the skin on the lateral abdominal side in 30 patients who received standardized therapy and in seven who did not. The accumulated surface skin thermal output of four temperature points was calculated from the estimated internal temperature of patients during the 50 min of each irradiation. An increased thermometry scale of the skin was added to the pretreatment axillar temperature of the patients to obtain a hypothetical internal body temperature that may be the possible core temperature. TATO was considered the heat effect of each treatment. Both temperature and output curves were recorded at 1-min intervals from 1 to 50 min. Body surface area was calculated by the DuBois formula (BSA = W0.425 × H0.725 × 0.007184) 10. Figure 1 summarizes the protocol of this study. All patients received the same CRT and hyperthermic therapy with or without neothermia.

Bottom Line: Three patients did not undergo surgery because of progressive disease (PD) and 13 refused.However, a patient with CRPD was in the higher total accumulated thermal output group.Using these parameters, the exact output, optimal thermal treatment, and contraindications or indications of this modality could be determined in a multi-institutional, future study.

View Article: PubMed Central - PubMed

Affiliation: Division of Surgery, Hidaka Hospital, Gunma, Japan.

No MeSH data available.


Related in: MedlinePlus