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Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine.

Elnaggar YS - Int J Nanomedicine (2015)

Bottom Line: This review is the first to gather major pharmaceutical applications of BSs from endogenous organotropism up to integration into nanomedicine, with a greater focus on the latter domain.The comparative advantages of BS-integrated nanomedicines over conventional nanocarriers have been noted.Paradoxical effects, current pitfalls, future perspectives, and opinions have also been outlined.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

ABSTRACT
The human body has long provided pharmaceutical science with biomaterials of interesting applications. Bile salts (BSs) are biomaterials reminiscent of traditional surfactants with peculiar structure and self-assembled topologies. In the pharmaceutical field, BSs were employed on the basis of two different concepts. The first concept exploited BSs' metabolic and homeostatic functions in disease modulation, whereas the second one utilized BSs' potential to modify drug-delivery characteristics, which recently involved nanotechnology. This review is the first to gather major pharmaceutical applications of BSs from endogenous organotropism up to integration into nanomedicine, with a greater focus on the latter domain. Endogenous applications highlighted the role of BS in modulating hypercholesterolemia and cancer therapy in view of enterohepatic circulation. In addition, recent BS-integrated nanomedicines have been surveyed, chiefly size-tunable cholate nanoparticles, BS-lecithin mixed micelles, bilosomes, probilosomes, and surface-engineered bilosomes. A greater emphasis has been laid on nanosystems for vaccine and cancer therapy. The comparative advantages of BS-integrated nanomedicines over conventional nanocarriers have been noted. Paradoxical effects, current pitfalls, future perspectives, and opinions have also been outlined.

No MeSH data available.


Related in: MedlinePlus

Tumor targeting of paclitaxel-loaded PEGylated nanocarrier of cholic acid in ovarian cancer xenograft.58Abbreviation: PEG, polyethylene glycol.
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f4-ijn-10-3955: Tumor targeting of paclitaxel-loaded PEGylated nanocarrier of cholic acid in ovarian cancer xenograft.58Abbreviation: PEG, polyethylene glycol.

Mentions: Nanocarriers based on BS-polymer conjugates could be successfully loaded with the lipophilic anticancer drug paclitaxel with high drug loading, antitumor activity, and stability compared with marketed products (Taxol® and Abraxane®). Targeted drug delivery to tumor sites with these novel micelles was demonstrated by near-infrared fluorescence imaging in nude mice bearing ovarian cancer xenograft (Figure 4).58


Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine.

Elnaggar YS - Int J Nanomedicine (2015)

Tumor targeting of paclitaxel-loaded PEGylated nanocarrier of cholic acid in ovarian cancer xenograft.58Abbreviation: PEG, polyethylene glycol.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4472153&req=5

f4-ijn-10-3955: Tumor targeting of paclitaxel-loaded PEGylated nanocarrier of cholic acid in ovarian cancer xenograft.58Abbreviation: PEG, polyethylene glycol.
Mentions: Nanocarriers based on BS-polymer conjugates could be successfully loaded with the lipophilic anticancer drug paclitaxel with high drug loading, antitumor activity, and stability compared with marketed products (Taxol® and Abraxane®). Targeted drug delivery to tumor sites with these novel micelles was demonstrated by near-infrared fluorescence imaging in nude mice bearing ovarian cancer xenograft (Figure 4).58

Bottom Line: This review is the first to gather major pharmaceutical applications of BSs from endogenous organotropism up to integration into nanomedicine, with a greater focus on the latter domain.The comparative advantages of BS-integrated nanomedicines over conventional nanocarriers have been noted.Paradoxical effects, current pitfalls, future perspectives, and opinions have also been outlined.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

ABSTRACT
The human body has long provided pharmaceutical science with biomaterials of interesting applications. Bile salts (BSs) are biomaterials reminiscent of traditional surfactants with peculiar structure and self-assembled topologies. In the pharmaceutical field, BSs were employed on the basis of two different concepts. The first concept exploited BSs' metabolic and homeostatic functions in disease modulation, whereas the second one utilized BSs' potential to modify drug-delivery characteristics, which recently involved nanotechnology. This review is the first to gather major pharmaceutical applications of BSs from endogenous organotropism up to integration into nanomedicine, with a greater focus on the latter domain. Endogenous applications highlighted the role of BS in modulating hypercholesterolemia and cancer therapy in view of enterohepatic circulation. In addition, recent BS-integrated nanomedicines have been surveyed, chiefly size-tunable cholate nanoparticles, BS-lecithin mixed micelles, bilosomes, probilosomes, and surface-engineered bilosomes. A greater emphasis has been laid on nanosystems for vaccine and cancer therapy. The comparative advantages of BS-integrated nanomedicines over conventional nanocarriers have been noted. Paradoxical effects, current pitfalls, future perspectives, and opinions have also been outlined.

No MeSH data available.


Related in: MedlinePlus