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Bone density, microarchitecture and stiffness in Caucasian and Caribbean Hispanic postmenopausal American women.

Zhou B, Wang J, Stein EM, Zhang Z, Nishiyama KK, Zhang CA, Nickolas TL, Shane E, Guo XE - Bone Res (2014)

Bottom Line: At the radius by high-resolution peripheral quantitative computed tomography (HR-pQCT), there were minimal differences between Hispanic and Caucasian women.Individual trabecula segmentation (ITS) analyses indicated that at the tibia, Hispanic women not only had significantly lower bone volume fraction, but also had significantly lower rod bone volume fraction, plate trabecular number, rod trabecular number and lower plate-plate, plate-rod and rod-rod junction densities compared to Caucasian women.In conclusion, Hispanic women had poorer bone mechanical and microarchitectural properties than Caucasian women, especially at the load-bearing distal tibia.

View Article: PubMed Central - PubMed

Affiliation: Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University , New York, USA.

ABSTRACT
Hispanic Americans of Caribbean origin are a fast-growing subset of the US population, but there are no studies on bone density, microstructure and biomechanical integrity in this minority group. In this study, we aimed to compare Caucasian and Caribbean Hispanic postmenopausal American women with respect to these characteristics. Thirty-three Caribbean Hispanics were age-matched to thirty-three Caucasian postmenopausal women. At the lumbar spine, the Hispanic women had significantly lower areal bone mineral density (aBMD). At the radius by high-resolution peripheral quantitative computed tomography (HR-pQCT), there were minimal differences between Hispanic and Caucasian women. At the tibia, Hispanic women had lower trabecular volumetric bone density and trabecular number, and higher trabecular separation. Individual trabecula segmentation (ITS) analyses indicated that at the tibia, Hispanic women not only had significantly lower bone volume fraction, but also had significantly lower rod bone volume fraction, plate trabecular number, rod trabecular number and lower plate-plate, plate-rod and rod-rod junction densities compared to Caucasian women. The differences in bone quantity and quality contributed to lower whole bone stiffness at the radius, and both whole bone and trabecular bone stiffness at the tibia in Hispanic women. In conclusion, Hispanic women had poorer bone mechanical and microarchitectural properties than Caucasian women, especially at the load-bearing distal tibia.

No MeSH data available.


Related in: MedlinePlus

Representative images indicating ITS analyses of individual trabecular plates (green) and rods (red) in radius and tibia for Caucasian and Hispanic women.
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fig1: Representative images indicating ITS analyses of individual trabecular plates (green) and rods (red) in radius and tibia for Caucasian and Hispanic women.

Mentions: We used ITS on the trabecular compartment to evaluate the plate- and rod-related microstructural parameters (Figure 1). Briefly, digital topological analysis-based skeletonization35 was first applied to transform the trabecular bone image into a reduced structural skeleton while preserving the topology.36–38 Digital topological classification was performed and each skeletal voxel was uniquely classified as either a surface or a curve type. Using an iterative reconstruction method, each voxel of the original image was classified belonging to either a plate (surface) or a rod (curve). Based on the 3D evaluations of the trabecular bone network, the following parameters were evaluated: plate and rod bone volume fraction (pBV/TV and rBV/TV); plate and rod number density (pTb.N and rTb.N, mm−1); plate–rod ratio (PR ratio); axial bone volume fraction (aBV/TV); plate and rod trabecular thickness (pTb.Th and rTb.Th, mm); plate trabecular surface (pTb.S, mm2); rod trabecular length (rTb.ℓ, mm); trabecular connection densities between plate–plate, plate–rod, and rod–rod (P–P Junc.D, P–R Junc.D and R–R Junc.D, mm−3). We also performed a direct measure of bone volume fraction (BV/TV) calculated as the voxels occupied by bone divided by total voxels. The predictive ability of ITS at limited resolutions was also validated through a comparison of ITS parameters based on HR-pQCT images and those based on µCT images for the same subject.39


Bone density, microarchitecture and stiffness in Caucasian and Caribbean Hispanic postmenopausal American women.

Zhou B, Wang J, Stein EM, Zhang Z, Nishiyama KK, Zhang CA, Nickolas TL, Shane E, Guo XE - Bone Res (2014)

Representative images indicating ITS analyses of individual trabecular plates (green) and rods (red) in radius and tibia for Caucasian and Hispanic women.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4472134&req=5

fig1: Representative images indicating ITS analyses of individual trabecular plates (green) and rods (red) in radius and tibia for Caucasian and Hispanic women.
Mentions: We used ITS on the trabecular compartment to evaluate the plate- and rod-related microstructural parameters (Figure 1). Briefly, digital topological analysis-based skeletonization35 was first applied to transform the trabecular bone image into a reduced structural skeleton while preserving the topology.36–38 Digital topological classification was performed and each skeletal voxel was uniquely classified as either a surface or a curve type. Using an iterative reconstruction method, each voxel of the original image was classified belonging to either a plate (surface) or a rod (curve). Based on the 3D evaluations of the trabecular bone network, the following parameters were evaluated: plate and rod bone volume fraction (pBV/TV and rBV/TV); plate and rod number density (pTb.N and rTb.N, mm−1); plate–rod ratio (PR ratio); axial bone volume fraction (aBV/TV); plate and rod trabecular thickness (pTb.Th and rTb.Th, mm); plate trabecular surface (pTb.S, mm2); rod trabecular length (rTb.ℓ, mm); trabecular connection densities between plate–plate, plate–rod, and rod–rod (P–P Junc.D, P–R Junc.D and R–R Junc.D, mm−3). We also performed a direct measure of bone volume fraction (BV/TV) calculated as the voxels occupied by bone divided by total voxels. The predictive ability of ITS at limited resolutions was also validated through a comparison of ITS parameters based on HR-pQCT images and those based on µCT images for the same subject.39

Bottom Line: At the radius by high-resolution peripheral quantitative computed tomography (HR-pQCT), there were minimal differences between Hispanic and Caucasian women.Individual trabecula segmentation (ITS) analyses indicated that at the tibia, Hispanic women not only had significantly lower bone volume fraction, but also had significantly lower rod bone volume fraction, plate trabecular number, rod trabecular number and lower plate-plate, plate-rod and rod-rod junction densities compared to Caucasian women.In conclusion, Hispanic women had poorer bone mechanical and microarchitectural properties than Caucasian women, especially at the load-bearing distal tibia.

View Article: PubMed Central - PubMed

Affiliation: Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University , New York, USA.

ABSTRACT
Hispanic Americans of Caribbean origin are a fast-growing subset of the US population, but there are no studies on bone density, microstructure and biomechanical integrity in this minority group. In this study, we aimed to compare Caucasian and Caribbean Hispanic postmenopausal American women with respect to these characteristics. Thirty-three Caribbean Hispanics were age-matched to thirty-three Caucasian postmenopausal women. At the lumbar spine, the Hispanic women had significantly lower areal bone mineral density (aBMD). At the radius by high-resolution peripheral quantitative computed tomography (HR-pQCT), there were minimal differences between Hispanic and Caucasian women. At the tibia, Hispanic women had lower trabecular volumetric bone density and trabecular number, and higher trabecular separation. Individual trabecula segmentation (ITS) analyses indicated that at the tibia, Hispanic women not only had significantly lower bone volume fraction, but also had significantly lower rod bone volume fraction, plate trabecular number, rod trabecular number and lower plate-plate, plate-rod and rod-rod junction densities compared to Caucasian women. The differences in bone quantity and quality contributed to lower whole bone stiffness at the radius, and both whole bone and trabecular bone stiffness at the tibia in Hispanic women. In conclusion, Hispanic women had poorer bone mechanical and microarchitectural properties than Caucasian women, especially at the load-bearing distal tibia.

No MeSH data available.


Related in: MedlinePlus