Diverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas.
Bottom Line: Although "FISH-positive" AKT1 and AKT2 gene increases (amplification/high-level polysomy) were found exclusively in the cases overexpressing total Akt, Akt1 or Akt2, respectively, AKT3 increase was irrelevant of Akt3 expression.Although AKT1 and AKT2 gene increase showed positive correlation with, or trend towards a positive correlation with tumor size (P = 0.0430, P = 0.0590, respectively), AKT3 did not.Because abnormality of Akt1/AKT1 and Akt2/AKT2 correlated with clinicopathological profiles, Akt1/2-specific targeting may open a novel therapeutic window for the group showing Akt deregulation.
Affiliation: Department of Pathology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.Show MeSH
Related in: MedlinePlus
Mentions: AKT1 was amplified in four cases (4.2%): one case each of AC (AKT1/reference signal ratio [AKT1 ratio] of 2.25, Fig.1), SCC (AKT1 ratio, 2.51), LCC (AKT1 ratio, 2.87) and SCLC (AKT1 ratio, 3.48). AKT1 increase with high-level polysomy of chromosome 14 was found in eight cases (8.4%). Sixty-five cases (68.4%) exhibited disomy.
Affiliation: Department of Pathology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.