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Monte Carlo-based dose calculation for (32)P patch source for superficial brachytherapy applications.

Sahoo S, Palani ST, Saxena SK, Babu DA, Dash A - J Med Phys (2015 Jan-Mar)

Bottom Line: Bhabha Atomic Research Centre (BARC) has indigenously developed (32)P nafion-based patch source (1 cm × 1 cm) for treating skin cancer.For an initial activity of 1 Bq distributed in 1 cm(2) surface area of the source, the calculated central axis depth dose values are 3.62 × 10(-10) GyBq(-1) and 8.41 × 10(-11) GyBq(-1)at 0.0125 and 1 mm depths in water, respectively.Hence, the treatment time calculated for delivering therapeutic dose of 30 Gy at 1 mm depth along the central axis of the source involving 37 MBq activity is about 2.7 hrs.

View Article: PubMed Central - PubMed

Affiliation: Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.

ABSTRACT
Skin cancer treatment involving (32)P source is an easy, less expensive method of treatment limited to small and superficial lesions of approximately 1 mm deep. Bhabha Atomic Research Centre (BARC) has indigenously developed (32)P nafion-based patch source (1 cm × 1 cm) for treating skin cancer. For this source, the values of dose per unit activity at different depths including dose profiles in water are calculated using the EGSnrc-based Monte Carlo code system. For an initial activity of 1 Bq distributed in 1 cm(2) surface area of the source, the calculated central axis depth dose values are 3.62 × 10(-10) GyBq(-1) and 8.41 × 10(-11) GyBq(-1)at 0.0125 and 1 mm depths in water, respectively. Hence, the treatment time calculated for delivering therapeutic dose of 30 Gy at 1 mm depth along the central axis of the source involving 37 MBq activity is about 2.7 hrs.

No MeSH data available.


Related in: MedlinePlus

Normalized dose profile along the x-axis of 32P-nafion-patch source for depth z = 1 mm
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Figure 5: Normalized dose profile along the x-axis of 32P-nafion-patch source for depth z = 1 mm

Mentions: Figure 4 presents the dose rate profiles along the x-axis of 32P-nafion-patch source for three different depths z = 0.5, 1 and 2 mm from the source surface. Figure 5 presents normalized dose values along the x-axis at depth 1 mm. The central axis dose value at 1 mm depth is used for normalization. Dose rate value at 3.5 mm away from the central axis is about 91% of the central axis value. Whereas dose rate at 5 mm away from the central axis is only 50% of the central axis value. Figures 6–8 show isodose profiles of the 32P-nafion-patch source at depths of 0.5, 1, and 2 mm. About 3.25–3.5 mm distance around the central axis is covered by about 90% isodose line for depths of 0.5, 1, and 2 mm. Hence, the 32P-nafion-patch source is effective for treatment of approximately 6.5–7.0 mm diameter lesions.


Monte Carlo-based dose calculation for (32)P patch source for superficial brachytherapy applications.

Sahoo S, Palani ST, Saxena SK, Babu DA, Dash A - J Med Phys (2015 Jan-Mar)

Normalized dose profile along the x-axis of 32P-nafion-patch source for depth z = 1 mm
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4471639&req=5

Figure 5: Normalized dose profile along the x-axis of 32P-nafion-patch source for depth z = 1 mm
Mentions: Figure 4 presents the dose rate profiles along the x-axis of 32P-nafion-patch source for three different depths z = 0.5, 1 and 2 mm from the source surface. Figure 5 presents normalized dose values along the x-axis at depth 1 mm. The central axis dose value at 1 mm depth is used for normalization. Dose rate value at 3.5 mm away from the central axis is about 91% of the central axis value. Whereas dose rate at 5 mm away from the central axis is only 50% of the central axis value. Figures 6–8 show isodose profiles of the 32P-nafion-patch source at depths of 0.5, 1, and 2 mm. About 3.25–3.5 mm distance around the central axis is covered by about 90% isodose line for depths of 0.5, 1, and 2 mm. Hence, the 32P-nafion-patch source is effective for treatment of approximately 6.5–7.0 mm diameter lesions.

Bottom Line: Bhabha Atomic Research Centre (BARC) has indigenously developed (32)P nafion-based patch source (1 cm × 1 cm) for treating skin cancer.For an initial activity of 1 Bq distributed in 1 cm(2) surface area of the source, the calculated central axis depth dose values are 3.62 × 10(-10) GyBq(-1) and 8.41 × 10(-11) GyBq(-1)at 0.0125 and 1 mm depths in water, respectively.Hence, the treatment time calculated for delivering therapeutic dose of 30 Gy at 1 mm depth along the central axis of the source involving 37 MBq activity is about 2.7 hrs.

View Article: PubMed Central - PubMed

Affiliation: Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.

ABSTRACT
Skin cancer treatment involving (32)P source is an easy, less expensive method of treatment limited to small and superficial lesions of approximately 1 mm deep. Bhabha Atomic Research Centre (BARC) has indigenously developed (32)P nafion-based patch source (1 cm × 1 cm) for treating skin cancer. For this source, the values of dose per unit activity at different depths including dose profiles in water are calculated using the EGSnrc-based Monte Carlo code system. For an initial activity of 1 Bq distributed in 1 cm(2) surface area of the source, the calculated central axis depth dose values are 3.62 × 10(-10) GyBq(-1) and 8.41 × 10(-11) GyBq(-1)at 0.0125 and 1 mm depths in water, respectively. Hence, the treatment time calculated for delivering therapeutic dose of 30 Gy at 1 mm depth along the central axis of the source involving 37 MBq activity is about 2.7 hrs.

No MeSH data available.


Related in: MedlinePlus