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DNA and sRAGE circulation in the early phase after polytrauma

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Various DAMPS, alarmins are released after trauma... The soluble receptor for advanced glycation endproducts (sRAGE) was reported to be associated with acute renal failure and duration of ventilation... Blood samples were collected within 24 hours of trauma (day 0) and on days 1, 3 and 5. sRAGE was measured by ELISA and cfDNA was measured by UV absorbance after plasma isolation... Median ISS was 39 and mortality was 21% (8/38)... During the first 5 days after trauma, the median concentration of sRAGE (Figure 1) decreased significantly over time (P < 0.0001) while median levels of DNA did not (P = 0.73), and remained elevated compared with normal control... No correlation was found with ISS... Patients initially in shock had lower levels of sRAGE or cfDNA (P < 0.05) and had received more fluid (10.6 l vs. 5.25 l) or blood (6 l vs. 0.5 l)... Day 3 and day 5 sRAGE levels were inversely correlated with PRBC received... Medians of sRAGE on days 0 (1,301 vs. 730 pg/ml) and day 1 (925 vs. 760 pg/ml) were significantly higher in nonsurvivors (P < 0.01)... Finally, day 0 sRAGE was correlated with the maximal (r = 0.44; P = 0.007) and the cumulative renal failure component of the MODS, over the 10 days (r = 0.48; P = 0.005)... DNA and sRAGE kinetics differ following trauma... Early elevation of sRAGE predicts mortality in univariate analysis and correlates with subsequent renal failure.

No MeSH data available.


sRAGE kinetics (days).
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Figure 1: sRAGE kinetics (days).

Mentions: Median ISS was 39 and mortality was 21% (8/38). During the first 5 days after trauma, the median concentration of sRAGE (Figure 1) decreased significantly over time (P < 0.0001) while median levels of DNA did not (P = 0.73), and remained elevated compared with normal control. No correlation was found with ISS. Patients initially in shock had lower levels of sRAGE or cfDNA (P < 0.05) and had received more fluid (10.6 l vs. 5.25 l) or blood (6 l vs. 0.5 l). Day 3 and day 5 sRAGE levels were inversely correlated with PRBC received. Medians of sRAGE on days 0 (1,301 vs. 730 pg/ml) and day 1 (925 vs. 760 pg/ml) were significantly higher in nonsurvivors (P < 0.01). Finally, day 0 sRAGE was correlated with the maximal (r = 0.44; P = 0.007) and the cumulative renal failure component of the MODS, over the 10 days (r = 0.48; P = 0.005).


DNA and sRAGE circulation in the early phase after polytrauma
sRAGE kinetics (days).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4470987&req=5

Figure 1: sRAGE kinetics (days).
Mentions: Median ISS was 39 and mortality was 21% (8/38). During the first 5 days after trauma, the median concentration of sRAGE (Figure 1) decreased significantly over time (P < 0.0001) while median levels of DNA did not (P = 0.73), and remained elevated compared with normal control. No correlation was found with ISS. Patients initially in shock had lower levels of sRAGE or cfDNA (P < 0.05) and had received more fluid (10.6 l vs. 5.25 l) or blood (6 l vs. 0.5 l). Day 3 and day 5 sRAGE levels were inversely correlated with PRBC received. Medians of sRAGE on days 0 (1,301 vs. 730 pg/ml) and day 1 (925 vs. 760 pg/ml) were significantly higher in nonsurvivors (P < 0.01). Finally, day 0 sRAGE was correlated with the maximal (r = 0.44; P = 0.007) and the cumulative renal failure component of the MODS, over the 10 days (r = 0.48; P = 0.005).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Various DAMPS, alarmins are released after trauma... The soluble receptor for advanced glycation endproducts (sRAGE) was reported to be associated with acute renal failure and duration of ventilation... Blood samples were collected within 24 hours of trauma (day 0) and on days 1, 3 and 5. sRAGE was measured by ELISA and cfDNA was measured by UV absorbance after plasma isolation... Median ISS was 39 and mortality was 21% (8/38)... During the first 5 days after trauma, the median concentration of sRAGE (Figure 1) decreased significantly over time (P < 0.0001) while median levels of DNA did not (P = 0.73), and remained elevated compared with normal control... No correlation was found with ISS... Patients initially in shock had lower levels of sRAGE or cfDNA (P < 0.05) and had received more fluid (10.6 l vs. 5.25 l) or blood (6 l vs. 0.5 l)... Day 3 and day 5 sRAGE levels were inversely correlated with PRBC received... Medians of sRAGE on days 0 (1,301 vs. 730 pg/ml) and day 1 (925 vs. 760 pg/ml) were significantly higher in nonsurvivors (P < 0.01)... Finally, day 0 sRAGE was correlated with the maximal (r = 0.44; P = 0.007) and the cumulative renal failure component of the MODS, over the 10 days (r = 0.48; P = 0.005)... DNA and sRAGE kinetics differ following trauma... Early elevation of sRAGE predicts mortality in univariate analysis and correlates with subsequent renal failure.

No MeSH data available.