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Cancer-Related Causes of Death among HIV-Infected Patients in France in 2010: Evolution since 2000.

Vandenhende MA, Roussillon C, Henard S, Morlat P, Oksenhendler E, Aumaitre H, Georget A, May T, Rosenthal E, Salmon D, Cacoub P, Costagliola D, Chêne G, Bonnet F, ANRS EN20 Mortalité 2010 study gro - PLoS ONE (2015)

Bottom Line: Among the 728 deaths reported in 2010, 262 were cancer-related (36%).Lung cancer was the most common cancer-related cause of death in 2010 (instead of non-Hodgkin lymphoma so far) and represented the leading cause of death in people living with HIV overall.Cancer prevention (especially smoking cessation), screening strategies and therapeutic management need to be optimized in HIV-infected patients in order to reduce mortality, particularly in the field of respiratory cancers.

View Article: PubMed Central - PubMed

Affiliation: INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France; Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistiques, Bordeaux, France; Service de médecine interne et maladies infectieuses, CHU de Bordeaux, Bordeaux, France.

ABSTRACT

Objectives: The current study aimed at describing the distribution and characteristics of malignancy related deaths in human immunodeficiency virus (HIV) infected patients in 2010 and at comparing them to those obtained in 2000 and 2005.

Methods: Data were obtained from three national surveys conducted in France in 2010, 2005 and 2000. The underlying cause of death was documented using a standardized questionnaire fulfilled in French hospital wards involved in the management of HIV infection.

Results: Among the 728 deaths reported in 2010, 262 were cancer-related (36%). After a significant increase from 28% in 2000 to 33% in 2005 and 36% in 2010, cancers represent the leading cause of mortality in HIV infected patients. The proportion of deaths attributed to non-AIDS/non-hepatitis-related cancers significantly increased from 2000 to 2010 (11% of the deaths in 2000, 17% in 2005 and 22% in 2010, p<0.001), while those attributed to AIDS-defining cancers decreased during the same period (16% in 2000, 13% in 2005 and 9% in 2010, p = 0.024). Particularly, the proportion of respiratory cancers significantly increased from 5% in 2000 to 6% in 2005 and 11% in 2010 (p = 0.004). Lung cancer was the most common cancer-related cause of death in 2010 (instead of non-Hodgkin lymphoma so far) and represented the leading cause of death in people living with HIV overall.

Conclusions: Cancer prevention (especially smoking cessation), screening strategies and therapeutic management need to be optimized in HIV-infected patients in order to reduce mortality, particularly in the field of respiratory cancers.

No MeSH data available.


Related in: MedlinePlus

Location of cancers (N = 268) among HIV-infected adults with underlying cause of death being cancer (N = 262), Mortalité 2010 survey, France.
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pone.0129550.g001: Location of cancers (N = 268) among HIV-infected adults with underlying cause of death being cancer (N = 262), Mortalité 2010 survey, France.

Mentions: Among the 728 cases with information provided in 2010, 268 malignancies were deemed responsible for the death of 262 patients, representing 36% of all deaths (Fig 1). Cancers-related causes of deaths were distributed as follow (Table 1): AIDS-related cancers (N = 71 in 68 patients, 9% of the causes of death), hepatitis-related cancer (N = 31, 4%) and NANH-related cancers (N = 166 in 163 patients, 22%). The main patients' characteristics according to the underlying cause of death are reported in Table 2. The three major lethal morbidities were lung cancer (n = 61), NHL (n = 53) and hepatocarcinoma (n = 31).


Cancer-Related Causes of Death among HIV-Infected Patients in France in 2010: Evolution since 2000.

Vandenhende MA, Roussillon C, Henard S, Morlat P, Oksenhendler E, Aumaitre H, Georget A, May T, Rosenthal E, Salmon D, Cacoub P, Costagliola D, Chêne G, Bonnet F, ANRS EN20 Mortalité 2010 study gro - PLoS ONE (2015)

Location of cancers (N = 268) among HIV-infected adults with underlying cause of death being cancer (N = 262), Mortalité 2010 survey, France.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4470800&req=5

pone.0129550.g001: Location of cancers (N = 268) among HIV-infected adults with underlying cause of death being cancer (N = 262), Mortalité 2010 survey, France.
Mentions: Among the 728 cases with information provided in 2010, 268 malignancies were deemed responsible for the death of 262 patients, representing 36% of all deaths (Fig 1). Cancers-related causes of deaths were distributed as follow (Table 1): AIDS-related cancers (N = 71 in 68 patients, 9% of the causes of death), hepatitis-related cancer (N = 31, 4%) and NANH-related cancers (N = 166 in 163 patients, 22%). The main patients' characteristics according to the underlying cause of death are reported in Table 2. The three major lethal morbidities were lung cancer (n = 61), NHL (n = 53) and hepatocarcinoma (n = 31).

Bottom Line: Among the 728 deaths reported in 2010, 262 were cancer-related (36%).Lung cancer was the most common cancer-related cause of death in 2010 (instead of non-Hodgkin lymphoma so far) and represented the leading cause of death in people living with HIV overall.Cancer prevention (especially smoking cessation), screening strategies and therapeutic management need to be optimized in HIV-infected patients in order to reduce mortality, particularly in the field of respiratory cancers.

View Article: PubMed Central - PubMed

Affiliation: INSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistiques, Bordeaux, France; Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistiques, Bordeaux, France; Service de médecine interne et maladies infectieuses, CHU de Bordeaux, Bordeaux, France.

ABSTRACT

Objectives: The current study aimed at describing the distribution and characteristics of malignancy related deaths in human immunodeficiency virus (HIV) infected patients in 2010 and at comparing them to those obtained in 2000 and 2005.

Methods: Data were obtained from three national surveys conducted in France in 2010, 2005 and 2000. The underlying cause of death was documented using a standardized questionnaire fulfilled in French hospital wards involved in the management of HIV infection.

Results: Among the 728 deaths reported in 2010, 262 were cancer-related (36%). After a significant increase from 28% in 2000 to 33% in 2005 and 36% in 2010, cancers represent the leading cause of mortality in HIV infected patients. The proportion of deaths attributed to non-AIDS/non-hepatitis-related cancers significantly increased from 2000 to 2010 (11% of the deaths in 2000, 17% in 2005 and 22% in 2010, p<0.001), while those attributed to AIDS-defining cancers decreased during the same period (16% in 2000, 13% in 2005 and 9% in 2010, p = 0.024). Particularly, the proportion of respiratory cancers significantly increased from 5% in 2000 to 6% in 2005 and 11% in 2010 (p = 0.004). Lung cancer was the most common cancer-related cause of death in 2010 (instead of non-Hodgkin lymphoma so far) and represented the leading cause of death in people living with HIV overall.

Conclusions: Cancer prevention (especially smoking cessation), screening strategies and therapeutic management need to be optimized in HIV-infected patients in order to reduce mortality, particularly in the field of respiratory cancers.

No MeSH data available.


Related in: MedlinePlus